纳米生物传感器探针材料：合成、组装及应用

宋丽平; 朱欣怡; 黄又举

doi:10.11777/j.issn1000-3304.2023.23011

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纳米生物传感器探针材料：合成、组装及应用

专论 | 更新时间：2023-05-31

- 纳米生物传感器探针材料：合成、组装及应用
- Probe Materials of Nanobiosensors: Synthesis, Assembly and Applications
- 高分子学报 2023年54卷第6期页码：870-891
- 作者机构：
  
  杭州师范大学材料与化学化工学院杭州 311121
- 作者简介：
  
  [ "黄又举，男，1984年生. 博士生导师，国家自然科学基金优秀青年科学基金获得者. 2005年于安徽大学获学士学位，2010年于中国科学技术大学获博士学位，师从李良彬教授. 2010~2014年，在新加坡南洋理工大学做博士后. 2014~2019年，在中国科学院宁波材料技术与工程研究所任项目研究员. 2017~2018年，在德国马普所高分子所做访问学者. 2019年9月至今，以卓越人才计划入职杭州师范大学，组建纳米生物传感器关键材料课题组. 主要从事功能高分子材料、胶体与表面科学、生物与食品安全检测等多学科交叉领域的研究工作. E-mail: yjhuang@hznu.edu.cn " ]
- 基金信息：
  
  国家自然科学基金(基金号 52222316)
- DOI：10.11777/j.issn1000-3304.2023.23011
  中图分类号：
- 纸质出版日期：2023-06-20，
  
  网络出版日期：2023-04-17，
  
  收稿日期：2023-01-13，
  
  录用日期：2023-03-01
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宋丽平,朱欣怡,黄又举.纳米生物传感器探针材料：合成、组装及应用[J].高分子学报,2023,54(06):870-891.

Song Li-ping,Zhu Xin-yi,Huang You-ju.Probe Materials of Nanobiosensors: Synthesis, Assembly and Applications[J].ACTA POLYMERICA SINICA,2023,54(06):870-891.
宋丽平,朱欣怡,黄又举.纳米生物传感器探针材料：合成、组装及应用[J].高分子学报,2023,54(06):870-891. DOI： 10.11777/j.issn1000-3304.2023.23011.

Song Li-ping,Zhu Xin-yi,Huang You-ju.Probe Materials of Nanobiosensors: Synthesis, Assembly and Applications[J].ACTA POLYMERICA SINICA,2023,54(06):870-891. DOI： 10.11777/j.issn1000-3304.2023.23011.

摘要

生物传感器因选择性高、分析速度快、准确度高等特点，在生物医学、环境监测及食品安全等领域应用广泛. 纳米探针材料是生物传感器中的核心部件，对检测信号的输出和放大，起到至关重要的作用.本文总结了近十年来本团队利用智能高分子精准调控纳米粒子合成的研究成果，发展了多种生长模式，量身定制出三十多种高效可医用探针材料；通过智能高分子修饰纳米探针表面，实现了不同维度(1D、2D和3D)的宏观可控自组装. 最后，基于设计的探针材料及其组装结构，构建了一系列生物传感器，探索了其在食品安全检测和医疗诊断领域的应用.

Abstract

Biosensors are devices that are sensitive to biological substances and convert their changes into monitorable optical and electrical signals. Owing to their remarkable advantages of high selectivity

fast analysis speed and high accuracy

they are widely applied in biomedical

environmental monitoring and food safety. Nanoprobes

which play vital roles in the output and amplification of signals

are the core components of biosensors. The signals of nanoprobes are intrinsically related to their morphology

surface chemistry and assembled structure. In this feature article

we summarized our research on the following three aspects: (1) Use of intelligent polymers to precisely regulate the synthesis of nanoprobes through three growth modes

such as intelligent growth mode

chemically anchored seed-growth mode and micellar limited growth mode. Up to now

we have customized more than 30 kinds of efficient biomedical probe materials; (2) Developed the intelligent multifunctional surface engineering strategies on probe materials

and achieved 1D

2D and 3D self-assembly of nanoprobes by adjusting the dynamic and thermodynamic parameters; (3) Based on the designed probe materials

different types of biosensors such as SERS biosensor

fluorescent biosensor

electrochemical biosensor and colorimetric biosensor are constructed

and their applications in food safety detection and biomedical diagnosis are explored.

关键词

生物传感器纳米探针智能高分子精准合成可控自组装

Keywords

BiosensorsNanoprobesSmart polymersPrecise synthesisControllable assembly

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