A series of triblock copolymers of methyl methacrylate (MMA) and 6-O-methacryloyl-1

2;3

4-di-O-isopropylidene-D-galactopyranose (MAIPGal) were synthesized by sequential atom transfer radical polymerization (ATRP) of MMA and MAIPGal

using 4

4′-biphenol di(2-bromoisobutyrate) (BiBBP) as the initiator.The chemical composition and molecular weights of the copolymers were characterized by 1H-NMR and GPC.It was demonstrated that the block chain length of both PMMA and PMAIPGal can be tuned by the feed molar ratio and monomer conversion.After de-protecting the isopropylidene groups of PMAIPGal

amphiphilic tri-block copolymers were obtained.Their self-assembly behavior in water was investigated by TEM.We investigated the effects of polymer structure

composition and initial concentration in good solvents on the final morphologies of the aggregates.For BAB copolymers

with the hydrophobic PMMA in the center

when the hydrophilic PGA was short

they tended to form vesicle like assemblies at lower polymer concentration.Increasing the chain length of the PGA chain

large irregular micelles were obtained.For ABA copolymers

small sized micelles were the main morphologies

but they were connected with each other due to the interaction of the PGA segments.The difference of self-assembly behavior was attributed to the polymer structure

which dominates the molecular packing as well as the chain segregation of the glycopolymer chains.