A new biocompatible copolymer

poly(dimethyl siloxane) graft poly(ethylene oxide) heparin(PDMS g PEO Hep) was prepared by the condensation between the hydroxyls of poly(dimethyl siloxane) graft ω hydroxyl poly(ethylene oxide) and heparin using dicyclohexylcarbodiimide(DCCI) as a dehydrating agent The IR spectrum of the product showed a weak peak at 1735 cm-1 ascrided to the ester groups The surface heparin content and activity were investigated by Toluidine Blue Heparin Assay(TBHA) and Thrombin Time Test (TTT). The polymer exhibited high surface heparin content and activity

Finally

the in vitro antithrombogenictity of glass surfaces coated with PDMS-g-PEOHep was assessed initially using Recalcification Time Test (RTT) and Prothrombin Time (PTT).The results indicated that PDMS-g-PEO-Hep showed expected blood compatibility and could be used as coating antithrombogenic materials.