PREPARATION AND PROTEIN ENCAPSULATION OF ETHER ESTER BLOCK COPLYMER MICROSPHERES WITH MICRON SIZE

LI Xiongwei; XIAO Jin; DENG Xianmo; JIA Wenxiang

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PREPARATION AND PROTEIN ENCAPSULATION OF ETHER ESTER BLOCK COPLYMER MICROSPHERES WITH MICRON SIZE

Research Article | 更新时间：2021-03-19

- PREPARATION AND PROTEIN ENCAPSULATION OF ETHER ESTER BLOCK COPLYMER MICROSPHERES WITH MICRON SIZE
- Acta Polymerica Sinica Issue 5, Pages: 543-548(1997)
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- Published：20 October 1997，
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LI Xiongwei, XIAO Jin, DENG Xianmo, JIA Wenxiang. PREPARATION AND PROTEIN ENCAPSULATION OF ETHER ESTER BLOCK COPLYMER MICROSPHERES WITH MICRON SIZE. [J]. Acta Polymerica Sinica (5):543-548(1997)
DOI：

LI Xiongwei, XIAO Jin, DENG Xianmo, JIA Wenxiang. PREPARATION AND PROTEIN ENCAPSULATION OF ETHER ESTER BLOCK COPLYMER MICROSPHERES WITH MICRON SIZE. [J]. Acta Polymerica Sinica (5):543-548(1997) DOI：

摘要

聚酯醚嵌段共聚物聚Ｄ

Ｌ乳酸聚乙二醇（ＰｏｌｙＤＬｌａｃｔｉｄｅＰｏｌｙｅｔｈｙｌｅｎｅｇｌｙｃｏｌ

ＰＬＡ-ＰＥＧ）采用本体聚合法在１８０℃及－９.５×１０－２ＭＰａ条件下制得．光谱分析证实产物结构．采用乳液溶剂蒸发法制备ＰＬＡＰＥＧ微球

粒径＜５μｍ．以复合乳液技术包裹蛋白．差示扫描量热分析确证ＰＬＡ-ＰＥＧ有效包裹蛋白．ＢＣＡ法检测微球蛋白含量．结果表明与均聚物ＰＬＡ比较

ＰＬＡ-ＰＥＧ不仅改善了成球条件而且蛋白的包裹效率明显提高．

Abstract

Block copolymer of Poly d

L lactide co polyethylene glycol(PLA PEG) was prepared by ring opening polymerization in vacuum at 180℃ with stannous octoate (SnOc2) as catalyst.By composite emulsion technique the PLA PEG microspheres with micron size encapsulating protein were prepared.An apparent reduction of the crystallinity of the microspheres carrying protein compared with that of non carrying protein determined by DSC indicated that protein can be effectively carried in the PLA-PEG microspheres.The size of the microsphaeres was determined by SEM.The quantification of protoin in the microspheres was carried out with BCA reagent. The results showed that comparing with homopolymer PLA

the ether-ester block copolymer PL-A-PEG is more advantageous to microsphere preparation and protein encapsulation.

关键词

聚乳酸聚乙二醇微球粒径蛋白包裹

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