In order to improve the hemocompatibility polysulfones (PSF) covalently-attached compound 1 (HTEP) containing phosphorylcholine structure via ether bond were prepared. Firstly

PSF was activated with chloromethylation reagent to give chloromethylated polysulfone 2 (CMPSF). Then compound 2 reacted with compound 1 by the reaction between benzyl chloride and hydroxyl group to give phosphorylcholine-coated PSF (PSF-HTEP) (3). The grafted materials 3 with different grafting ratios of compound 1 were characterized by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR)

element analysis (EA) and H-atom nuclear magnetic response spectroscopy (1H-NMR). The surface properties of PSF-HTEP (3) membranes were tested by contact angle measurements and the results showed that the membranes of grafted materials 3 possessed more hydrophilic surface with the increase of the number of grafting ratio of compound 1

as expected. The blood compatibilities of membranes (3) were evaluated by testing their hemolytic properties and comparing the experimental results of platelet-rich plasma adhesion of PSF-HTEP (3). The results showed that all hemolytic rates of membranes (3) with different grafted ratios were less than 5% and that the number of platelet adhesion on the surface of PSF-HTEP (3) decreased dramatically with the increase of graft ratio of 1

and in particular even no platelet adhesion was observed on the surface of PSF-18.1% 1 membrane. Such a novel PSF-HTEP (3) containing phosphorylcholine structure showed improving blood compatibility

which was supported by the hypothesis of maintaining natural behavior and revealed a promising potential use in hemocompatibility materials.