Construction of Nanoparticle/Polymer Composite Photothermal Nanoplatforms and Therapeutic Applications

Min Lin; Dan-dan Wang; Shu-wei Liu; Ding Zhou; Hao Zhang; Chang Liu; Hong-chen Sun

doi:10.11777/j.issn1000-3304.2015.14359

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Construction of Nanoparticle/Polymer Composite Photothermal Nanoplatforms and Therapeutic Applications

Feature Articles | 更新时间：2021-03-19

- Construction of Nanoparticle/Polymer Composite Photothermal Nanoplatforms and Therapeutic Applications
- Acta Polymerica Sinica Issue 2, Pages: 133-146(2015)
- 作者机构：
  
  1. 吉林大学超分子结构与材料国家重点实验室,长春,130012
  2. 吉林大学口腔医学院病理科,长春,130021
  3. 吉林大学口腔医学院口腔正畸科,长春,130021
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2015.14359
  CLC：
- Published：20 February 2015，
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Min Lin, Dan-dan Wang, Shu-wei Liu, Ding Zhou, Hao Zhang, Chang Liu, Hong-chen Sun. Construction of Nanoparticle/Polymer Composite Photothermal Nanoplatforms and Therapeutic Applications. [J]. Acta Polymerica Sinica (2):133-146(2015)
DOI：

Min Lin, Dan-dan Wang, Shu-wei Liu, Ding Zhou, Hao Zhang, Chang Liu, Hong-chen Sun. Construction of Nanoparticle/Polymer Composite Photothermal Nanoplatforms and Therapeutic Applications. [J]. Acta Polymerica Sinica (2):133-146(2015) DOI： 10.11777/j.issn1000-3304.2015.14359.

摘要

叙述了一系列增强纳米粒子光热性能的方法

包括通过自组装方法调控纳米粒子的空间排列

进而优化电子结构和光热转化性能;在纳米粒子及其组装结构外表面进一步包覆具有光热性质的聚合物等.这些手段能够有效地增强光热试剂在近红外光区的消光能力

达到增强光热性能的目的.另外

包覆聚合物壳层后

纳米粒子的胶体稳定性、光稳定性以及生物兼容性都能得到进一步提高

为后续的体外细胞实验和动物体内肿瘤模型实验提供了可能.

Abstract

Nanoparticles (NPs) that are capable to convert near-infrared (NIR) irradiation into thermal energy have been demonstrated as the robust media for tumour curing. In this scenario

the photothermal performance of NPs greatly depends on their size

morphology

surface property

as well as the self-assembly architectures. Therefore

the practical applications of photothermal NPs in cancer therapy are determined by the technique progresses of nano-fabrications and multi-functional integration. In this scenario

the photothermal performance of NPs greatly depends on their size

morphology

surface property

as well as the self-assembly architectures. Therefore

the practical applications of photothermal NPs in cancer therapy are determined by the technique progresses of nano-fabrications and multi-functional integration. In this article

we summary a series of methods to enhance NP photothermal performance

such as control preparation of nanostructures

directing NPs self-assembly into specific architectures

and further photothermal polymer coating. The combination of these issues ensures the improvement of photothermal performance

colloidal and physiological stability

as well as biocompatibility.

关键词

光热治疗纳米平台自组装纳米粒子复合物

Keywords

Photothermal therapyNanoplatformSelf-assemblyNanoparticleComposites

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Related Institution

College of Chemistry and Chemical Engineering, Taishan University

School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Key Laboratory of High Performance Polymer Materials and Technology of Ministry of Education, State Key Laboratory of Coordination Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University

State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology

Department of Polymer Science and Engineering, University of Massachusetts, Amherst

Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology

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