PLGA/QDs nanocomposite films

containing different concentrations of CdSe-ZnS quantum dots

were prepared via the method of solution casting.The objective of this research was to investigate the optical properties and in vitro degradation of poly(lactide-co-glycolide)/CdSe-ZnS quantum dots (PLGA/QDs) nanocomposites.Photoluminescence spectra and ultraviolet-visible spectra explained that there was no effect on the luminescence property as well as the absorbance of light of QDs after being composited with PLGA

whose intensities increase with increasing the concentration of QDs in PLGA films.The results of gel permeation chromatography (GPC) for PLGA and PLGA/QDs nanocomposites films showed that the weight-average molecular weight (Mw) of unfilled PLGA and PLGA/QDs nanocomposites films decreased from 13300 to 3000 and from 13300 to 2400 respectively in three weeks

and their corresponding molecular weight distributions index decreased from 4.10 to 2.19 and from 4.10 to 2.21.The results of pH for phosphate-buffered saline (PBS) revealed that the pH value firot lowered and then increased.Both the results of GPC and pH confirmed that the presence and uniform dispersion of QDs in the PLGA

to some extend

led to a faster degradation rate of the PLGA compared with unfilled PLGA.The PL intensity of PLGA/QDs nanocomposites films decreased along with the degradation process.Pores and wrinkles began to emerge on the surfaces of the films after degradation and increased gradually as the degradation time extended.The results suggest that the PLGA/QDs nanocomposites films can be prepared via the method of solution casting

and PLGA/QDs nanocomposites have potential applications for monitoring in vivo degradation of PLGA.