Progress on the Application of Small-angle X-ray Scattering in the Study of Protein and Protein Complexes

Ce Shi; Yun-qi Li

doi:10.11777/j.issn1000-3304.2015.15048

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Progress on the Application of Small-angle X-ray Scattering in the Study of Protein and Protein Complexes

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- Progress on the Application of Small-angle X-ray Scattering in the Study of Protein and Protein Complexes
- Acta Polymerica Sinica Issue 8, Pages: 871-883(2015)
- 作者机构：
  
  中国科学院长春应用化学研究所合成橡胶重点实验室及先进化学电源实验室,长春,130022
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2015.15048
  CLC：
- Published：20 August 2015，
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Ce Shi, Yun-qi Li. Progress on the Application of Small-angle X-ray Scattering in the Study of Protein and Protein Complexes. [J]. Acta Polymerica Sinica (8):871-883(2015)
DOI：

Ce Shi, Yun-qi Li. Progress on the Application of Small-angle X-ray Scattering in the Study of Protein and Protein Complexes. [J]. Acta Polymerica Sinica (8):871-883(2015) DOI： 10.11777/j.issn1000-3304.2015.15048.

摘要

小角X射线散射(SAXS)是能够表征多种形态的样品

解析从原子到几百纳米尺度上微结构的一种重要技术手段.蛋白质复合物正是在这一空间尺度范围表现出了丰富的生理活性.近年来基于分子结构药物设计的飞速发展

极大地促进了SAXS在研究蛋白质复合物中的应用.本文简要介绍了SAXS解析结构的原理、仪器设备和数据采集分析方法.围绕蛋白质复合物的两方面研究热点

溶液中的蛋白构象以及蛋白质复合物中的结构和相互作用解析

对SAXS在该领域的研究进展和一般分析方法进行了综述.

Abstract

Small angle X-ray scattering (SAXS) is a powerful technique to study the interaction and structure at spatial scale from several to hundreds nanometers.Structure-based drug design has vigorously promoted the application of SAXS in protein complex study.Physical principles

facilities

data collection and interpretations are concisely introduced.Then two cutting-edge topics of SAXS applications including protein conformation in solutions

and the interaction and structure in protein complexes

combined with routine information acquirement and tips in these cases have been reviewed.

关键词

小角X射线散射蛋白质复合物结构相互作用

Keywords

Small angle X-ray scatteringProtein complexStructureInteraction

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