A series of polypeptide-based amphiphilic hybrid copolymers were synthesized via the combination of ring-opening polymerization (ROP) and thiol-yne click reaction.First

poly(ethylene glycol)-block-poly(-propargyl-L-glutamate) (PEG-b-PPLG) diblock copolymers were prepared by ROP using a monoamine terminated poly(ethylene glycol) (PEG-NH2) as the initiator.Subsequently

the PPLG block was modified with a saturated hydrocarbon (1-octanethiol) or a superhydrophobic fluorinated side group (1-mercapto-1H

1H

2H

2H-perfluorooctane) by thiol-yne reaction with high efficiency.The self-assembly behavior of all obtained copolymers in solutions was finely investigated and characterized using Fourier transform infrared (FTIR) spectroscopy

circular dichroism (CD) spectroscopy

dynamic light scattering (DLS) and transmission electron microscopy (TEM).The polypeptide blocks were shown to exhibit -helix conformations

and all copolymers could spontaneously self-assemble into sphere or rodlike micelles in aqueous or organic solution due to the different solubility of the distinct blocks.Such strategy offers a general and efficient way to achieve various amphiphlic hybrid copolymers using simple copolymer precursors

especially for the preparation of functional self-assembly materials with various architectures.Moreover

the self-assemblies of these functional amphiphilic copolypeptides could be easily modulated by tuning the optional macroinitiators and a series of functional thiols.