Biomimetic Glycopolymer Tethered Gold Nanorods for Remote NIR Triggered Drug Release

Rong-guang Song; Yan-chun Li; Tong-fei Shi; Dan-feng Pei; Guo Zhang

doi:10.11777/j.issn1000-3304.2015.15157

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Biomimetic Glycopolymer Tethered Gold Nanorods for Remote NIR Triggered Drug Release

Rapid Communications | 更新时间：2021-03-19

- Biomimetic Glycopolymer Tethered Gold Nanorods for Remote NIR Triggered Drug Release
- Acta Polymerica Sinica Issue 10, Pages: 1128-1132(2015)
- 作者机构：
  
  1. 吉林大学材料科学与工程学院,长春,130023
  2. 吉林大学第一医院,长春,130021
  3. 中国科学院长春应用化学研究所高分子物理与化学国家重点实验室,长春,130022
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2015.15157
  CLC：
- Published：20 October 2015，
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Rong-guang Song, Yan-chun Li, Tong-fei Shi, Dan-feng Pei, Guo Zhang. Biomimetic Glycopolymer Tethered Gold Nanorods for Remote NIR Triggered Drug Release. [J]. Acta Polymerica Sinica (10):1128-1132(2015)
DOI：

Rong-guang Song, Yan-chun Li, Tong-fei Shi, Dan-feng Pei, Guo Zhang. Biomimetic Glycopolymer Tethered Gold Nanorods for Remote NIR Triggered Drug Release. [J]. Acta Polymerica Sinica (10):1128-1132(2015) DOI： 10.11777/j.issn1000-3304.2015.15157.

摘要

通过配体交换的方法成功将含糖聚合物PGAMA14-PCL32-SH接枝到纳米金棒的表面(Gly@Au NRs).借助X-射线光电子能谱(XPS)、动态光散射(DLS)、热重分析(TGA)等对Gly@Au NRs进行了表征.为了得到药物控释所需要的合适的实验条件

研究了近红外光照射下Gly@Au NRs在水溶液中的光热转换行为.用Gly@Au NRs包裹药物姜黄素(CUR)

研究了药物的体外释放

发现近红外光能有效控制药物的体外释放.细胞实验结果表明含糖聚合物的接枝大大提高了纳米金棒的生物相容性.因此

Gly@Au NRs复合材料能够作为生物相容性载体材料

并实现近红外光触发的药物的可控释放.

Abstract

Biomimetic thiol terminated glycopolymers PGAMA-PCL-SH were effectively anchored on the surface of gold nanorods to prepare the biomimetic glycopolymers modified gold nanoparticles (Gly@Au NRs).UV-Vis

XPS

DLS and TGA were used to characterize Gly@Au NRs.NIR-induced heating of an aqueous suspension of Gly@Au NRs was performed.Then

curcumin (CUR) was loaded into Gly@Au NRs and the in vitro release of CUR was studied.We found that the NIR-laser irradiation can control the drug release effectively.Moreover

cell viability studies revealed that the cytotoxicity of the Gly@Au NRs complexes was remarkably improved as compared to that of the original Au NRs.Consequently

the Gly@Au NRs complexes can be used as biocompatible vehicles to realize the controlled drug release by remote NIR-laser irradiation.

关键词

含糖聚合物纳米金棒可控释放

Keywords

GlycopolymerGold nanorodsControlled release

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College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences

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