This paper aimed to describe a bioactive polymer biointerface for specifical of recognition endothelial cells.In particular

a random copolymer

poly(ethylene glycol) methacrylate (PEGMA) and glycidyl methacrylate (GMA) (PEGMA-GMA) was synthesized using AIBN as an initiator and grafted on PET substrate by solvent evaporation method.PEGMA unit could reduce nonspecific adsorption of platelet

protein and cells.GMA unit contains reactive epoxide functional groups on the side chains is beneficial to immobilization of antibody or peptide.The peptide sequence Arg-Gly-Asp (RGD)

Arg-Glu-Asp-Val (REDV) and Tyr-Ile-Gly-Ser-Arg (YIGSR) were known to bind preferentially endothelial cells.As a result

endothelial specific peptide (RGD

REDV and YIGSR) was conjugated through the epoxy groups in GMA segments.1H-NMR was used to characterize the composition of the polymer.Surfaces were characterized by X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) to confirm the modification reactions.UV spectrum was used to calculate the content of peptide.Cell adhesion experiments showed that peptide modified surfaces inhibit the adhesion of smooth muscle cells (SMCs) and promote endothelial cells (ECs) growth

exhibiting excellent specific recognition of ECs on biomimetic coatings.Comparing with polymer coating modified by RGD and YIGSR

REDV conjugated surface exhibited the highest selectivity for ECs.The multifunctional polymer coating with anti-fouling and ECs specific adhesion produced an excellent prospect in cardiovascular stent implantation.