Synthesis and Characterization of Main Chain Ester-containing Poly(dimethylaminoethyl methacrylate)-based Copolymers

Yi-ye Song; Jing Li; Tao Bai; Li Liu; Xiao-qiang Xue; Wen-yan Huang; Xiao-lei Qian; Hong-jun Yang; Bi-biao Jiang

doi:10.11777/j.issn1000-3304.2016.15318

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Synthesis and Characterization of Main Chain Ester-containing Poly(dimethylaminoethyl methacrylate)-based Copolymers

Research Article | 更新时间：2021-03-19

- Synthesis and Characterization of Main Chain Ester-containing Poly(dimethylaminoethyl methacrylate)-based Copolymers
- Acta Polymerica Sinica Issue 6, Pages: 769-774(2016)
- 作者机构：
  
  常州大学材料科学与工程学院江苏省材料表面科学与技术重点实验室江苏省光伏科学与工程协同创新中心常州大学怀德学院常州 213164
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2016.15318
  CLC：
- Published：2016-6，
  
  Received：16 November 2015，
  
  Revised：25 January 2015，
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Yi-ye Song, Jing Li, Tao Bai, Li Liu, Xiao-qiang Xue, Wen-yan Huang, Xiao-lei Qian, Hong-jun Yang, Bi-biao Jiang. Synthesis and Characterization of Main Chain Ester-containing Poly(dimethylaminoethyl methacrylate)-based Copolymers. [J]. Acta Polymerica Sinica (6):769-774(2016)
DOI：

Yi-ye Song, Jing Li, Tao Bai, Li Liu, Xiao-qiang Xue, Wen-yan Huang, Xiao-lei Qian, Hong-jun Yang, Bi-biao Jiang. Synthesis and Characterization of Main Chain Ester-containing Poly(dimethylaminoethyl methacrylate)-based Copolymers. [J]. Acta Polymerica Sinica (6):769-774(2016) DOI： 10.11777/j.issn1000-3304.2016.15318.

摘要

通过己内酯(CL)和甲基丙烯酸二甲氨基乙酯(DMAEMA)的杂化聚合制备了主链含酯键结构单元的聚甲基丙烯酸二甲氨基乙酯的共聚物

并通过核磁(

H-NMR)、凝胶渗透色谱(GPC)、示差扫描量热仪(DSC)等对聚合物的结构和性能进行了表征.结果表明

膦腈碱

-BuP

能高效催化CL和DMAEMA的杂化聚合

得到含CL和DMAEMA 2种结构单元的刺激响应性可降解共聚物.该共聚物只存在一个玻璃化转变温度且共聚物组成与单体投料比接近.GPC数据表明共聚物的数均分子量范围为1.63×10

~2.47×10

分子量分布为2.11~2.54.酯键的引入赋予了聚合物良好的降解性能

同时使其低临界相转变温度(LCST)从52.6℃降到了44.5℃.TEM结果表明得到的共聚物能够在水中形成平均直径约60 nm的胶束.

Abstract

The main chain ester-containing poly(dimethylaminoethyl methacrylate)-based copolymers were successfully synthesized by the hybrid copolymerization of caprolactone (CL) and dimethylaminoethyl methacrylate (DMAEMA).The structure and properties of the resulting copolymers have been characterized by nuclear magnetic resonance spectroscopy (NMR)

gel permeation chromatography (GPC)

differential scanning calorimetry (DSC) and so on.The results showed that the phosphazene base 1-tert-butyl-4

4-tris-(dimethylamino)-2

2-bis[tris(dimethylamino)-phosphoranylidenamino]-2 Λ5

Λ5-catenadi-(phosphazene) (

-BuP

) displayed high activity for the copolymerization of CL and DMAEMA.The resulted copolymers consisting of CL and DMAEMA segments were random copolymers with only one glass transition temperature.The proportions of CL to DMAEMA in the copolymers were consistent with the feed ratios.The number average molecular weights of the resulted copolymers detected by GPC were in the range from 1.63×10

to 2.47×10

and the polydispersity (PDI) changed from 2.11 to 2.54.The introducing of hydrolytically cleavable ester endows the copolymer good degradability

but decreases the lower critical solution temperature (LCST) from 52.6℃ to 44.5℃.The TEM result showed that the amphiphilic polymers could form micelles around 60 nm in water.This reported method provides a facile approach for preparing stimuli-responsive degradable polymers under mild conditions

and will be useful in bio-related applications.

关键词

甲基丙烯酸二甲氨基乙酯己内酯刺激响应降解

Keywords

Dimethylaminoethyl methacrylateCaprolactoneStimuli responsibilityDegradability.

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