Acrylate-terminated PLA-PEG-PLA macromer (PELA-DA) and β-cyclodextrin polymer modified with glycidyl methacrylate (CDP-g-GMA) were synthesized

and copolymer films with different compositions were prepared via UV-initiated free radical polymerization of PELA-DA

CDP-g-GMA and N-vinylpyrrolidone (VP) in DMF.The 1H-NMR analysis confirmed the successful synthesis of PELA-DA and CDP-g-GMA macromers.The structure and properties of the copolymer films were characterized by X-ray diffraction (XRD)

dynamic thermomechanical analysis (DTMA)

thermal gravity analysis (TGA)

water uptake and in vitro degradation.XRD exhibited that the crystallinity of PELA-DA and CDP-g-GMA components was suppressed and disturbed in the copolymer films.The water uptake and in vitro degradation measurements showed that the hydrophilicity and hydrolytic degradation of the copolymer films were improved due to the introduction of CDP-g-GMA macromer.DTMA and TGA results displayed that storage modulus (E')

glass transition temperature (Tg) and thermal stability of the resultant copolymer films increased as the contents of β-cyclodextrin polymer macromer incorporated increased.In addition

using methyl orange (MO) as a water-soluble model drug

the MO loading and release profiles of the copolymer films were evaluated.It was found that the MO loading amounts of the films increased with the increase of incorporated CDP-g-GMA content.After a burst release of 12 h at the first stage

the MO release profile was in a slow and sustained manner.