Preparation, Biological Properties and Degradation Studies on the Electrospun Membranes of Poly (<italic style="font-style: italic">p</italic>-dioxanone-<italic style="font-style: italic">co</italic>-trimethylene carbonate)

Li-nan Li; Yong-jiang Liu; Shu-hui Liu; Huan Yang; Cheng-dong Xiong; Dong-liang Chen

doi:10.11777/j.issn1000-3304.2017.16157

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Preparation, Biological Properties and Degradation Studies on the Electrospun Membranes of Poly (p-dioxanone-co-trimethylene carbonate)

Research Article | 更新时间：2021-05-18

- Preparation, Biological Properties and Degradation Studies on the Electrospun Membranes of Poly (p-dioxanone-co-trimethylene carbonate)
- Acta Polymerica Sinica Issue 4, Pages: 651-660(2017)
- 作者机构：
  
  1.中国科学院成都有机化学研究所成都 610041
  2.中国科学院大学北京 100049
  3.青岛出入境检验检疫局青岛 266001
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2017.16157
  CLC：
- Published：2017-4，
  
  Received：4 June 2016，
  
  Revised：24 July 2016，
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Li-nan Li, Yong-jiang Liu, Shu-hui Liu, Huan Yang, Cheng-dong Xiong, Dong-liang Chen. Preparation, Biological Properties and Degradation Studies on the Electrospun Membranes of Poly (p-dioxanone-co-trimethylene carbonate). [J]. Acta Polymerica Sinica (4):651-660(2017)
DOI：

Li-nan Li, Yong-jiang Liu, Shu-hui Liu, Huan Yang, Cheng-dong Xiong, Dong-liang Chen. Preparation, Biological Properties and Degradation Studies on the Electrospun Membranes of Poly (p-dioxanone-co-trimethylene carbonate). [J]. Acta Polymerica Sinica (4):651-660(2017) DOI： 10.11777/j.issn1000-3304.2017.16157.

摘要

通过静电纺丝技术，将二元共聚物聚（对氧环己酮-三亚甲基碳酸酯）（PDT）制成了膜材料，采用扫描电镜（SEM）观察了静电纺膜的形貌，当共聚物中TMC组分含量越高时，纤维丝之间黏结越严重.采用静态接触角仪测定了静电纺膜的接触角，表征了共聚物的亲疏水性，PDT的亲水性介于PPDO与PTMC均聚物静电纺膜之间.对PDT共聚物静电纺膜进行了L929大鼠成纤维细胞培养实验，MTT和荧光染色结果说明PDT膜的细胞相容性良好.通过水解及酶解实验考察了材料的降解过程，PDT静电纺膜在脂肪酶存在下降解速率加快，材料的失重率、分子量损失、材料形貌破坏程度等均高于水解样品，这说明脂肪酶对含有TMC组分的聚合物的降解有促进作用.同时，降解过程中PBS溶液的pH值变化说明TMC组分的加入，减缓了降解过程中酸性物质的产生.

Abstract

Nano-structured fibers of the synthesized poly (

-dioxanone-

-trimethylene carbonate) (PDT) were prepared by electrospinning technique. Their physicochemical and biological properties were evaluated with the standards for biomedical materials

and it was found that the content of trimethylene carbonate (TMC) units in PDT copolymer could change these properties. As observed by the scanning electron microscopy (SEM)

more TMC units in the copolymer would lead to severer fiber bonding

which probably is due to the ductility of TMC segments. The results of static water contact angle testing for the electrospun membranes demonstrated that the hydrophilicity of PDT was between that of PPDO and PTMC. The growth status of L929 mouse fibroblasts on the as-spun membranes of PDT and PPDO was evaluated by the fluorescent micrographs and MTT assay. It was shown that the cells grew well

which suggested good biocompatibility of these copolymers and their suitability in biomedical fields. The

in vitro

biodegradability of the electrospun membranes in phosphate buffered saline (PBS) and PBS with lipase was separately investigated

via

measurements of mass loss

retention

as well as variations in crystallinity

thermal properties

pH value

and morphology. After 35 days of degradation

mass and

of the polymers significantly reduced while slight differences appeared in pH values before and after. Among the samples

the pH value exhibited the most descent for PBS with PPDO and the least for PBS with PTMC; pH decrement of PBS with PDT was in the middle. These results pointed out that the existence of TMC units in the polymers reduced acidic products in the degradation process

which was good for implanted materials. The changes of SEM images of PTMC at different degradation time indicated that PTMC degraded by surface erosion. And the changes of thermal properties of PDT indicated that PTMC was susceptible to enzymatic degradation by lipase. The lipase enzymatic degradation rate of the polymers containing TMC segments was faster than the hydrolytic degradation rate

which illustrated this point.

关键词

对氧环己酮三亚甲基碳酸酯静电纺膜降解

Keywords

p-DioxanoneTrimethylene carbonateElectrospun membranesDegradation

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School of Materials and Environment

Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products

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Green Polymer and Catalysis Technology Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University

Anhui Province Key Laboratory of Environment-friendly Polymer Materials, College of Chemistry and Chemical Engineering, Anhui University

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Preparation, Biological Properties and Degradation Studies on the Electrospun Membranes of Poly (p-dioxanone-co-trimethylene carbonate)

DOI：10.11777/j.issn1000-3304.2017.16157

摘要

Abstract

关键词

Keywords

references