Preparation and Properties Investigation on a Kind of Pseudopolyrotaxane Hydrogel with High Intensity

Xiao-zhen Li; Si-chao Tian; Peng-fei Sun; Qu-li Fan; Wei Huang

doi:10.11777/j.issn1000-3304.2017.16311

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Preparation and Properties Investigation on a Kind of Pseudopolyrotaxane Hydrogel with High Intensity

Research Article | 更新时间：2021-03-19

- Preparation and Properties Investigation on a Kind of Pseudopolyrotaxane Hydrogel with High Intensity
- Acta Polymerica Sinica Issue 6, Pages: 952-958(2017)
- 作者机构：
  
  1.南京邮电大学有机电子与信息显示国家重点实验室培育基地信息材料与纳米技术研究院江苏先进生物与化学制造协同创新中心南京 210023
  2.南京工业大学江苏省柔性电子重点实验室先进材料研究院江苏先进生物与化学制造协同创新中心南京 211816
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2017.16311
  CLC：
- Published：2017-6，
  
  Received：11 October 2016，
  
  Revised：6 December 2016，
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Xiao-zhen Li, Si-chao Tian, Peng-fei Sun, Qu-li Fan, Wei Huang. Preparation and Properties Investigation on a Kind of Pseudopolyrotaxane Hydrogel with High Intensity. [J]. Acta Polymerica Sinica (6):952-958(2017)
DOI：

Xiao-zhen Li, Si-chao Tian, Peng-fei Sun, Qu-li Fan, Wei Huang. Preparation and Properties Investigation on a Kind of Pseudopolyrotaxane Hydrogel with High Intensity. [J]. Acta Polymerica Sinica (6):952-958(2017) DOI： 10.11777/j.issn1000-3304.2017.16311.

摘要

通过点击化学在聚乙二醇单甲醚（MPEG）端基分别修饰了葡萄糖（Glc）、甘露糖（Man）和半乳糖（Gal），制备了一系列端基为糖的聚乙二醇单甲醚（MPEG-Glc、MPEG-Man和MPEG-Gal），此类端基为糖的MPEG和

-环糊精（

-CD）混合后能够形成稳定的准聚轮烷（PPR）水凝胶，而端基没有修饰糖的MPEG和

-CD只能形成黏度较大的溶液而无法形成稳定存在的凝胶.通过流变仪测试可知水凝胶的弹性模量高达1.0×10

Pa，远大于文献中通过黏土等增强的PPR水凝胶的强度，我们认为该MPEG端基的糖之间能够形成新的“糖交联”点从而有效提高了凝胶的强度.通过向水凝胶中加入和MPEG端基的糖具有相互作用的苯硼酸半酯聚合物（PNIPAM-

-PBOB）或刀豆蛋白（ConA），发现在凝胶中加入PNIPAM-

-PBOB或ConA后可明显降低PPR水凝胶的强度.通过扫描电镜（SEM）和X射线衍射（XRD）对水凝胶的形貌以及微观结构进行表征分析，发现此凝胶的微观结构和文献中报道的PPR水凝胶基本一致，进一步证明了上述结论.

Abstract

As animportant member of supramolecular hydrogel

pseudopolyrotaxane (PPR) hydrogel has attracted tremendous attention in recent years due to its good biocompatibility. Compared with conventional approaches reported

a new method was developed for PPR hydrogel preparation in this study

which can increase the strength of the hydrogel more efficiently. First

monoaccharide group-functionalized methoxypolyethylene glycols (MPEG)(MPEG-Glc

MPEG-Man and MPEG-Gal) were synthesizedby click chemistry. After that

a series of PPR hydrogels (Glc-PPR

Man-PPR and Gal-PPR) with high stability and strengthwere successfully prepared

via

the "host-guest" interactions between

-CD and monoaccharide group-functionalized MPEG(MPEG-Glc

MPEG-Man and MPEG-Gal

respectively). However

similar hydrogel cannot be obtained using

-CD and MPEG without monoaccharide modification. The properties of Glc-PPR

Man-PPR and Gal-PPR were characterizedby rheometer test

X-ray diffraction (XRD) and scan electron microscopy (SEM).Surprisingly

rheometer test results indicated that the elasticity modulus of Glc-PPR

Man-PPR and Gal-PPR could be up to 1.0 × 10

which was much higher than that of the clay-enhanced hydrogel in the previous reports. As for this phenomenon

we propose that new sugar cross-linking agents from "carbohydrate-carbohydate interaction" have constructed among monoaccharide terminals of MPEG

so that the strength of Glc-PPR

Man-PPR and Gal-PPR could be improved efficiently. Furthermore

in order to demonstrate the mechanism of the strength enhancement of PPR hydrogel

phenylboronic acid cyclic monoester (PNIPAM-

-PBOB) and concanavalin A (Con A) were added into Glc-PPR

Man-PPR and Gal-PPR

respectively to eliminate the sugar cross-linking agents

which led to a significant decrease in the strengthof Glc-PPR

Man-PPR and Gal-PPR. SEM and XRD results showed that the microstructures of Glc-PPR

Man-PPR and Gal-PPR were basically identical withPPR hydrogel reported in the references

which further confirmed that the PPR hydrogel was prepared successfully. Given its many merits of high intensity

non-toxicity and excellent biocompatibility of the obtained PPR hydrogel

it is expected that the PPR as prepared here will play an important role in drug delivery and biomedical engineering.

关键词

α-环糊精包结络合PPR水凝胶糖-糖相互作用

Keywords

α-CyclodextrinsHost-guest inclusion complexationPPR hydrogelCarbohydrate-carbohydate interaction

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