Peptides/Amphiphilic Peptides Based Silk Fibroin of Bombxy Mori and Their Self-assembly and Functionalization

Hong Chen; Zheng-zhong Shao

doi:10.11777/j.issn1000-3304.2018.18083

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Peptides/Amphiphilic Peptides Based Silk Fibroin of Bombxy Mori and Their Self-assembly and Functionalization

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- Peptides/Amphiphilic Peptides Based Silk Fibroin of Bombxy Mori and Their Self-assembly and Functionalization
- Acta Polymerica Sinica Vol. 0, Issue 8, Pages: 987-996(2018)
- 作者机构：
  
  聚合物分子工程国家重点实验室复旦大学高分子科学系和先进材料实验室　上海 200438
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2018.18083
  CLC：
- Published：2018-8，
  
  Received：19 March 2018，
  
  Revised：9 April 2018，
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Hong Chen, Zheng-zhong Shao. Peptides/Amphiphilic Peptides Based Silk Fibroin of Bombxy Mori and Their Self-assembly and Functionalization. [J]. Acta Polymerica Sinica 0(8):987-996(2018)
DOI：

Hong Chen, Zheng-zhong Shao. Peptides/Amphiphilic Peptides Based Silk Fibroin of Bombxy Mori and Their Self-assembly and Functionalization. [J]. Acta Polymerica Sinica 0(8):987-996(2018) DOI： 10.11777/j.issn1000-3304.2018.18083.

摘要

多肽的自组装因其独特性质和作用已成为超分子化学、高分子功能材料和生物医用材料等领域的研究热点. 桑蚕丝蛋白具有高度重复的多肽序列，其组装行为和相应的结构对动物丝及丝蛋白基材料的形成和特有的优异综合性能起到了至关重要的作用. 通过特定的酶降解桑蚕丝蛋白能够以较为经济的方式获得多种明确序列的多肽，并可进一步方便地制备功能性的两亲性多肽. 本文结合国内外多肽自组装的研究现状，对本课题组在桑蚕丝蛋白多肽/两亲性多肽的制备、组装以及功能化等方面的研究成果进行了总结，同时也展望了其在若干领域中的实际应用.

Abstract

Given the unique properties and functions

such as bioactivity and good biocompatibility

the self-assembly of peptide

specially amphipathic peptide

and their applications have become the research focus in the fields of supermolecular chemistry as well as functional polymeric and biomedical materials. Generally

most of peptide building blocks are prepared from chemical synthesis such as solid phase peptide synthesis

or genetic engineering. Those " bottom up” methods may be suffered by time consuming and cost

which limit the practical application of assembly peptides materials. Degradation of natural proteins such as casein

corn protein and so on

provides us a convenient way to obtain the mixed peptides. However

most of researches about these mixtures are focused on their bio-functions or surfactant property. The usage of them as building blocks of assembly peptide is overlooked. Silk fibroin from

Bombyx mori

silkworm silk is with highly repetitive sequences

such as GAGAGY and GAGAGS

their different assembly properties and the relevant structures not only play an important role in the forming of animal silks and silk fibroin based materials

but also have crucial effect on their excellent comprehensive performance. According to the selectivity of different enzymes

there are enzymes which work on the Tyr-Gly or Ala-Gly peptide bone

respectively. Therefore

it provides us the opportunity to harvest the silk peptides with special sequence economically

via

degrading silk fibroin by those enzymes. We introduced in this paper the enzymatic degradation

a " top down” method on obtaining peptide with specific sequences from silk fibroin and investigated their assembly properties. In addition

we summarized the construction of functionalization amphiphilic peptides with one of those silk peptides (GAGAGAGY) as building block as well as their assembly and applications like the forming pH responsive peptide hydrogel

flexible thermochromism materials and unique peptide surfactant. Finally

we prospected the application of top down method on obtaining functional peptide building blocks as well as application of the silk peptide obtained by this way on construction functional peptides.

关键词

天然蛋白质选择性降解氨基酸序列水凝胶响应性

Keywords

Natural proteinSelective degradationAmino acid sequencesHydrogelResponsive

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School of Chemistry, Xi'an Jiaotong University

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