Injectable Thermogels Based on Block Copolymers of Appropriate Amphiphilicity

Shu-quan Cui; Lin Yu; Jian-dong Ding

doi:10.11777/j.issn1000-3304.2018.18084

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Injectable Thermogels Based on Block Copolymers of Appropriate Amphiphilicity

Feature Articles | 更新时间：2021-01-26

- Injectable Thermogels Based on Block Copolymers of Appropriate Amphiphilicity
- Acta Polymerica Sinica Vol. 0, Issue 8, Pages: 997-1015(2018)
- 作者机构：
  
  聚合物分子工程国家重点实验室复旦大学高分子科学系　上海 200438
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2018.18084
  CLC：
- Published：2018-8，
  
  Received：29 March 2018，
  
  Revised：27 May 2018，
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Shu-quan Cui, Lin Yu, Jian-dong Ding. Injectable Thermogels Based on Block Copolymers of Appropriate Amphiphilicity. [J]. Acta Polymerica Sinica 0(8):997-1015(2018)
DOI：

Shu-quan Cui, Lin Yu, Jian-dong Ding. Injectable Thermogels Based on Block Copolymers of Appropriate Amphiphilicity. [J]. Acta Polymerica Sinica 0(8):997-1015(2018) DOI： 10.11777/j.issn1000-3304.2018.18084.

摘要

部分两亲性嵌段共聚物的水溶液随温度升高呈现可逆的溶胶-凝胶转变. 如果转变温度介于室温和体温之间，该类体系可以在室温或更低温与药物或细胞混合，并可以注射；一旦注射进入体内，在体温下原位凝胶化，可以自动包裹药物或细胞，且该过程不依赖于化学反应. 由聚乙二醇和疏水的可降解聚酯构成的嵌段共聚物的水体系在合适分子量等条件下具备以上的可逆热致凝胶化特性，成为一类极有前景的新型生物医用材料，但其中仍有大量的高分子科学问题需要解决. 作者课题组十余年来在可注射热致水凝胶领域开展了系统研究：发现了聚酯-聚醚嵌段共聚物的端基效应、分子量分布效应等重要现象，总结了热致水凝胶分子设计的规律；揭示了物理凝胶化的机理，并显著扩展了可热致凝胶化聚合物的成分范围；发展了热致水凝胶面向医学应用的新策略. 本专论主要以近年来复旦大学生物医用材料课题组对聚乙二醇/聚酯类可注射性热致水凝胶体系的研究为重点，介绍该类高分子材料的物理凝胶化机理和调控规律，并根据相关动物实验结果展示其潜在的临床应用前景.

Abstract

Some amphiphilic copolymers in water can undergo a reversible sol-gel transition upon heating. If the transition temperature lies between room temperature and body temperature

the aqueous system can be readily mixed with drugs or cells at room temperature

and the mixture is injectable; the injected formulation is physically gelled at body temperature

and the gelation is free of any chemical crosslinking. This affords an amazing biomaterial type

yet many questions are open in light of fundamental research and potential clinical applications. In particular

block copolymers composed of hydrophilic poly(ethylene glycol) (PEG) and some hydrophobic biodegradable polyesters such as poly(lactide-

-glycolide) (PLGA) are of great clinical potential

yet of very unclear physical crosslinking points. This feature article summarizes the corresponding extensive investigations in the authors’ group led by Ding at Fudan University for a decade. The Ding group has found the significant effects of the end groups of the copolymer

molar mass dispersity

and other molecular parameters on thermogellability

and revealed the corresponding rules of molecular design

based on their polymer chemistry studies. For instance

with increase in

under either given number average or weight average molecule weight

the sol-gel transition temperature for some block copolymer aqueous systems could shift unidirectionally

which indicates that the effect of molecular weight distribution could not be interpreted simply from addition of the effects of molecular weight or

affords an independent adjustable parameter. The Ding group has shed light on the mechanism of their thermogelling by putting forward the model of percolated micelle network to describe the internal structure of the physical hydrogel

and extended the range of the thermogellable molecular composition of the copolymers to a large extent by establishing a blend strategy

based on their polymer physics studies. The Ding group have also put forward many strategies for the clinical applications of the thermogels using animal models

including prevention of postoperative tissue adhesion

submucosal cushion for endoscopic submucosal dissection

sustained release carriers of antitumor drugs such as camptothecin derivatives

long-acting formulations of polypeptide drugs such as exenatide in treatment of type II diabetes

and tissue engineering of cartilage. The Ding group has also laid a material basis towards potential products of medical devices and drug carriers including the appropriate way of sterilization and improvement of the handling property of the synthesized polymers. The Ding group suggest some perspectives in the end of this feather article.

关键词

两亲性嵌段共聚物物理水凝胶生物医用材料

Keywords

Amphiphilic block copolymerPhysical hydrogelBiomedical materials

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Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

School of Applied Chemistry and Engineering, University of Science and Technology of China

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University

Department of Gynaecology and Obstetrics, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University

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