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Design and Synthesis of Bioinspired Multiscale Hydrogels: from Interface to Three-dimensional Network
- Acta Polymerica Sinica Vol. 0, Issue 9, Pages: 1155-1174(2018)
- 作者机构：
北京航空航天大学化学学院 北京 100191
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2018.18108
CLC：Published：2018-9，
Received：18 April 2018，
Revised：9 May 2018，
扫 描 看 全 文
Yu-xia Liu, Lie Chen, Zi-guang Zhao, Ruo-chen Fang, Ming-jie Liu. Design and Synthesis of Bioinspired Multiscale Hydrogels: from Interface to Three-dimensional Network. [J]. Acta Polymerica Sinica 0(9):1155-1174(2018)
Yu-xia Liu, Lie Chen, Zi-guang Zhao, Ruo-chen Fang, Ming-jie Liu. Design and Synthesis of Bioinspired Multiscale Hydrogels: from Interface to Three-dimensional Network. [J]. Acta Polymerica Sinica 0(9):1155-1174(2018) DOI： 10.11777/j.issn1000-3304.2018.18108.
摘要
水凝胶是以大量水为分散介质的三维高分子网络. 高分子网络和水分子之间的氢键将水束缚在网络内部，从而使体系丧失流动性并转变成一种准固态物质. 水凝胶能够在多种外界刺激下改变形状和体积，因此在软体机器人、柔性电子器件和传感器等领域具有广泛的应用前景，也引起了科研人员的关注. 在生物软组织中，多尺度结构(如表面微/纳米结构，有序三维网状结构)的存在对于生物材料的自清洁、耐冻、环境适应性和优异的机械性能等功能至关重要. 受生物水凝胶结构与功能特性的启发，研究人员开发了一系列对各种机械和环境条件具有高度适应性的仿生多尺度水凝胶. 本文将从水凝胶的二维界面和三维网络的设计2个方面总结和讨论近年来仿生多尺度水凝胶的研究成果. 二维界面设计包括表面化学/物理修饰、表面微/纳米结构构筑，能够调节水凝胶的表面浸润性和黏附性，拓展水凝胶在生物医学、海洋防污等领域的应用；三维网络设计，如引入非共价交联作用、设计有序网络结构、复合异质网络等，能够赋予水凝胶自修复性能、各向异性、高强度、形状记忆性能及抗冻性等优异的特性，拓展了水凝胶在可穿戴设备、软体机器人等领域以及复杂环境中的应用. 最后我们对仿生水凝胶网络的设计、异质网络的分散以及无损表征等方面未来的发展以及该领域所存在的挑战作出展望.
Abstract
Hydrogels are three-dimensional polymeric networks with large amount of water as the dispersion medium. The hydrogen bonds between polymer networks and water bind water in the networks
thus making the system lose its fluidity and transform quasi-solid substances. Hydrogel materials can greatly change their shape and volume in response to diverse stimuli
and thus have attracted considerable attention due to their promising applications in soft robots
flexible electronics and sensors. In biological soft tissues
the existence of multi-scale structures
for example
surface micro/nano structures and ordered three-dimensional network structures is crucial to provide biological materials with functionalities
including self-cleaning
freezing tolerance
adaptivity and excellent mechanical performance. Taking inspiration from nature
researchers have increasingly developed a series of bioinspired multiscale hydrogels with high adaptability to various mechanical and environmental conditions. In this review
we first introduce the history of hydrogel. Secondly
the relationship between natural gel materials and their excellent function are summarized. Then the recent researches of bioinspired multi-scale hydrogels focusing on hydrogel ’s surfaces and three-dimensional network designing are discussed. As we mentioned
surface chemical/physical modification and micro/nano structure construction are typical strategies
which can adjust the wettability and adhesion behaviors of hydrogel surface
thus expanding the application of hydrogel in the fields of biomedicine and marine antifouling. In addition
the strategies of three-dimensional networks’ designing
such as introducing non-covalent cross-linking
designing ordered network structure and fabricating heterogeneous networks
are introduced respectively. These strategies can give hydrogels excellent properties including self-healing
anisotropy
high strength
shape memory and freezing tolerance. The development of these biomimetic multiscale hydrogels has expanded the application of hydrogel materials in the fields of wearable devices
software robots
and complex environments. Finally
the current challenges about design of hydrogels’ network
the dispersion of heterogeneous networks
the non-destructive characterization of hydrogels and future perspectives in this field will also be discussed.
关键词
仿生水凝胶多尺度二维界面三维网络
Keywords
Bioinspired hydrogelsMultiscaleInterfaceThree-dimensional network
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