Silver Nanoparticles Reduced by Dialdehyde Amylose and Their Application in Collagen-based Antibacterial Dressing

Miao Han; De-rong Li; Liu-qing Yuan; Yong-bo Lyu; Li-ming Ge; De-fu Li; Chang-dao Mu

doi:10.11777/j.issn1000-3304.2018.18242

您当前的位置：

首页 >

文章列表页 >

Silver Nanoparticles Reduced by Dialdehyde Amylose and Their Application in Collagen-based Antibacterial Dressing

Research Article | 更新时间：2021-01-26

- Silver Nanoparticles Reduced by Dialdehyde Amylose and Their Application in Collagen-based Antibacterial Dressing
  增强出版
- Acta Polymerica Sinica Vol. 50, Issue 4, Pages: 366-374(2019)
- 作者机构：
  
  1.四川大学化学工程学院　成都 610065
  2.临沂市兰山区人民医院　临沂 276000
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2018.18242
  CLC：
- Published：2019-4，
  
  Published Online：28 January 2019，
  
  Received：16 November 2018，
  
  Revised：28 December 2018，
扫描看全文
Miao Han, De-rong Li, Liu-qing Yuan, Yong-bo Lyu, Li-ming Ge, De-fu Li, Chang-dao Mu. Silver Nanoparticles Reduced by Dialdehyde Amylose and Their Application in Collagen-based Antibacterial Dressing. [J]. Acta Polymerica Sinica 50(4):366-374(2019)
DOI：

Miao Han, De-rong Li, Liu-qing Yuan, Yong-bo Lyu, Li-ming Ge, De-fu Li, Chang-dao Mu. Silver Nanoparticles Reduced by Dialdehyde Amylose and Their Application in Collagen-based Antibacterial Dressing. [J]. Acta Polymerica Sinica 50(4):366-374(2019) DOI： 10.11777/j.issn1000-3304.2018.18242.

摘要

首先通过控制高碘酸钠的添加量制备了具有不同醛基含量的双醛直链淀粉(DA)，然后以DA为环境友好型还原剂和稳定剂合成纳米银(AgNP)，之后采用浸泡法将胶原海绵浸入DA-AgNP水溶液中制备胶原/DA-AgNP复合抗菌敷料(AgNPs-Col). AgNP在被均匀引入到胶原海绵基质中的同时，溶液中DA的醛基与胶原的氨基发生席夫碱化学交联反应，进而改善胶原基材料的理化性能. 研究结果表明，通过选用合适醛基含量的DA以及控制反应时间成功合成了球形AgNPs. 经DA交联和AgNPs填充改性的AgNPs-Col具有致密的微观结构，因此其孔隙率、吸水率和水蒸气透过率均降低. AgNPs-Col敷料能够多次反复吸水和挤压快速排水，而其初始形貌不被破坏，具有海绵的特性. 此外，AgNPs-Col敷料对革兰氏阳性菌和革兰氏阴性菌都具有显著的抗菌性能和阻隔能力. 与此同时，AgNPs-Col敷料还具有良好的血液相容性.

Abstract

As the multidrug-resistant (MDR) microorganism caused by antibiotics abuse has posed a serious threat to human health and even life security

it is of great significance to study and develop new antibacterial materials for the treatment of MDR microbial infection. Silver nanoparticles (AgNPs) are prevalent choices for biomedical applications due to their robust antimicrobial activity against bacteria and fungus

especially the MDR microorganism

while their synthesis

via

environmentally friendly approaches remains challengeable. On the other hand

it has been increasingly valued to investigate the incorporation of AgNPs into collagen

for as-fabricated nanocomposite wound dressing can be tailored with unique biological functions

excellent biocompatibility

weak antigenicity

favorable biodegradability

and effective antibacterial activity. Herein

dialdehyde amylose (DA) with different aldehyde contents was firstly prepared by controlling the amount of sodium periodate added

and AgNPs were subsequently synthesized using the DA obtained as both eco-friendly reducing agent and stabilizer. With collagen dressing swollen directly into the DA-AgNPs aqueous solution

the final product of collagen-based antibacterial dressing (AgNPs-Col) could be afforded after freeze-drying. It is worth noting that collagen could be crosslinked by DA

via

Schiff’s base reaction in the process of AgNPs incorporation. In-depth exploration revealed that partially oxidized DA functioned as both a reducing agent and a stabilizer to transform AgNO

into AgNPs after heating for 150 min

and the participation of AgNPs into DA crosslinking process endowed AgNPs-Col dressing with a dense microstructure. In addition to the desirable decrease in porosity

water absorption rate

and vapor transmission rate

as-fabricated composite dressing also demonstrated a shape memory behavior as well as repeatability between swelling and physical pressing. More importantly

AgNPs-Col dressing exhibited a strong antibacterial activity against both Gram-positive and Gram-negative bacteria while serving as a robust barrier to bacterial infiltration in the meantime. Together with an excellent performance in blood compatibility

the AgNPs-Col antibacterial dressing developed in this work has promising application prospects in the field of biomedical applications.

关键词

双醛直链淀粉胶原纳米银抗菌活性复合材料创伤敷料

Keywords

Dialdehyde amyloseCollagenSilver nanoparticlesAntibacterial activityComposite materialWound dressing

references

Ito K, Saito A, Fujie T, Nishiwaki K, Miyazaki H, Kinoshita M, Saitoh D, Ohtsubo S, Takeoka S . Acta Biomater , 2015 . 24 87 - 95 . DOI:10.1016/j.actbio.2015.05.035http://doi.org/10.1016/j.actbio.2015.05.035 .

Olsen D R, Pletonen J, Jaakko L, Chu M L, Uitto J . J Clin Invest , 1989 . 83 ( 3 ): 791 - 796.

Wang Yuli(王玉丽) . Foreign Medical Pharmacy(国外医学药学分册) , 2002 . 29 ( 2 ): 113 - 116.

Ge L M, Xu Y B, Li X Y, Yuan L, Tan H, Li D F, Mu C D . ACS Sustain Chem Eng , 2018 . 6 ( 7 ): 9153 - 9166 . DOI:10.1021/acssuschemeng.8b01482http://doi.org/10.1021/acssuschemeng.8b01482 .

Morones J R, Elechiguerra J L, Camacho A, Holt K, Kouri J B, Ramirez J T, Yacaman M J . Nanotechnology , 2005 . 16 ( 10 ): 2346 - 2353.

Agnihotri S, Mukherji S, Mukherji S . Nanoscale , 2013 . 5 ( 16 ): 7328 - 7340.

Xiu Z M, Zhang Q B, Puppala H L, Colvin V L, Alvarez P J J . Nano Lett , 2012 . 12 ( 8 ): 4271 - 4275 . DOI:10.1021/nl301934whttp://doi.org/10.1021/nl301934w .

Feng Q L, Wu J, Chen G Q, Cui F Z, Kim T N, Kim J O . J Biomed Mater Res B , 2000 . 52 ( 4 ): 662 - 668 . DOI:10.1002/(ISSN)1097-4636http://doi.org/10.1002/(ISSN)1097-4636 .

Qin Xinbo(秦新波) . Shandong Textile Science & Technology(山东纺织科技) , 2010 . 51 ( 2 ): 41 - 43 . DOI:10.3969/j.issn.1009-3028.2010.02.014http://doi.org/10.3969/j.issn.1009-3028.2010.02.014 .

Wang H, Qiao X, Chen J, Wang X, Ding S . Mater Chem Phys , 2005 . 94 ( 2 ): 449 - 453.

Xu W, Jin W, Lin L, Zhang C, Li Z, Li Y, Song R, Li B . Carbohyd Polym , 2014 . 101 961 - 967 . DOI:10.1016/j.carbpol.2013.10.032http://doi.org/10.1016/j.carbpol.2013.10.032 .

Chang Tianxiao(常添笑), Zhang Hangtian(张航天), Lu Congjie(卢聪杰), Wu Yixian(吴一弦) . Acta Polymerica Sinica (高分子学报) , 2018 . ( 6 ): 700 - 711.

Kim S, Choi J E, Choi J, Chung K H, Park K, Yi J, Ryu D Y . Toxicol in Vitro , 2009 . 23 ( 6 ): 1076 - 1084 . DOI:10.1016/j.tiv.2009.06.001http://doi.org/10.1016/j.tiv.2009.06.001 .

Chen X, Schluesener H J . Toxicol Lett , 2008 . 176 ( 1 ): 1 - 12 . DOI:10.1016/j.toxlet.2007.10.004http://doi.org/10.1016/j.toxlet.2007.10.004 .

Wei Mengjuan(魏梦娟), Zhang Qi(章琦), Zhang Hangtian(张航天), Wu Yixian(吴一弦) . Acta Polymerica Sinica(高分子学报) , 2018 . ( 4 ): 464 - 474.

Hussain S M, Hess K L, Gearhart J M, Geiss K T, Schlager J J . Toxicol in Vitro , 2005 . 19 ( 7 ): 975 - 983 . DOI:10.1016/j.tiv.2005.06.034http://doi.org/10.1016/j.tiv.2005.06.034 .

Reidy B, Haase A, Luch A, Dawson K A, Lynch I . Materials , 2013 . 6 ( 6 ): 2295 - 2350 . DOI:10.3390/ma6062295http://doi.org/10.3390/ma6062295 .

Samberg M E, Oldenburg S J, Monteiro-Riviere N A . Environ Health Persp , 2010 . 118 ( 3 ): 407 - 413 . DOI:10.1289/ehp.0901398http://doi.org/10.1289/ehp.0901398 .

Nganga S, Moritz N, Kolakovic R, Jakobsson K, Nyman J O, Borgogna M, Travan A, Crosera M, Donati I, Vallittu P K, Sandler N . Biofabrication , 2014 . 6 ( 4 ): 1 - 7.

Travan A, Pelillo C, Donati I, Marsich E, Benincasa M, Scarpa T, Semeraro S, Turco G, Gennaro R, Paoletti S . Biomacromolecules , 2009 . 10 1429 - 1435 . DOI:10.1021/bm900039xhttp://doi.org/10.1021/bm900039x .

Dhar S, Murawala P, Shiras A, Pokharkar V, Prasad B L V . Nanoscale , 2012 . 4 ( 2 ): 563 - 567 . DOI:10.1039/C1NR10957Jhttp://doi.org/10.1039/C1NR10957J .

Emam H E, Ahmed H B . Carbohyd Polym , 2016 . 135 300 - 307 . DOI:10.1016/j.carbpol.2015.08.095http://doi.org/10.1016/j.carbpol.2015.08.095 .

Song J, Zhang P, Cheng L, Liao Y, Xu B, Bao R, Wang W, Liu W . J Mater Chem B , 2015 . 3 ( 20 ): 4231 - 4241 . DOI:10.1039/C5TB00205Bhttp://doi.org/10.1039/C5TB00205B .

Tan H, Wu B, Li C, Mu C D, Li H, Lin W . Carbohyd Polym , 2015 . 129 17 - 24 . DOI:10.1016/j.carbpol.2015.04.029http://doi.org/10.1016/j.carbpol.2015.04.029 .

Mu C D, Li D F, Lin W, Ding Y, Zhang G . Biopolymers , 2007 . 86 ( 4 ): 282 - 287 . DOI:10.1002/(ISSN)1097-0282http://doi.org/10.1002/(ISSN)1097-0282 .

Zi Y X, Zhu M J, Li X Y, Xu Y B, Wei H, Li D F, Mu C D . Carbohyd Polym , 2018 . 192 118 - 125 . DOI:10.1016/j.carbpol.2018.03.060http://doi.org/10.1016/j.carbpol.2018.03.060 .

Zhou Y, Li X Y, Lv Y B, Shi Y F, Zeng Y, Li D F, Mu C D . Carbohyd Polym , 2016 . 138 41 - 48 . DOI:10.1016/j.carbpol.2015.11.040http://doi.org/10.1016/j.carbpol.2015.11.040 .

Vigneshwaran N, Nachane R P, Balasubramanya R H, Varadarajan P V . Carbohyd Res , 2006 . 341 ( 12 ): 2012 - 2018 . DOI:10.1016/j.carres.2006.04.042http://doi.org/10.1016/j.carres.2006.04.042 .

Alipilakkotte S, Sreejith L . Mater Lett , 2018 . 217 33 - 38 . DOI:10.1016/j.matlet.2018.01.034http://doi.org/10.1016/j.matlet.2018.01.034 .

Mi F L, Shyu S S, Wu Y B, Lee S T, Shyong J Y, Huang R N . Biomaterials , 2001 . 22 ( 2 ): 165 - 173 . DOI:10.1016/S0142-9612(00)00167-8http://doi.org/10.1016/S0142-9612(00)00167-8 .

Peles Z, Zilberman M . Acta Biomater , 2012 . 8 ( 1 ): 209 - 217 . DOI:10.1016/j.actbio.2011.08.022http://doi.org/10.1016/j.actbio.2011.08.022 .

Gorbet M B, Sefton M V . Biomaterials , 2004 . 25 ( 26 ): 5681 - 5703 . DOI:10.1016/j.biomaterials.2004.01.023http://doi.org/10.1016/j.biomaterials.2004.01.023 .

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Preparation and Radiation Shielding Properties of Sandwich-structured Lead-containing Polyimide Materials

Thermo-sensitive Semi-interpenetrating Collagen Hydrogels and Effects on L929 Cell's Behavior

Enzyme-modified Gelatin/Silver Nanoparticle Composite Biomaterial

Preparation of Ethanolamine Functionalized Graphene and Its PVB Composites

PREPARATION AND PROPERTIES OF POLY(STYRENE-N-VINYL-2-PYROLIDONE)/Ag COMPOSITE PARTICLES

Related Author

No data

Related Institution

School of Chemistry and Chemical Engineering, Southeast University

School of Material Science and Engineering, Tianjin Polytechnic University

Department of Polymer Materials and Engineering, School of Materials Science and Engineering, Wuhan University of Technology

School of Materials Science and Engineering, South China University of Technology, Guang Zhou

School of Chemistry and Materials Science, Ludong University

Postal code：100190
Tel：010-62588927 Email：gfzxb@iccas.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05002797号-8 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰