Controllable Synthesis and Biological Properties of Unimolecular Polymer Nanomaterials

Dan Zhang; Wei Wu; Xi-qun Jiang

doi:10.11777/j.issn1000-3304.2019.18191

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Controllable Synthesis and Biological Properties of Unimolecular Polymer Nanomaterials

Feature Articles | 更新时间：2021-01-26

- Controllable Synthesis and Biological Properties of Unimolecular Polymer Nanomaterials
- Acta Polymerica Sinica Vol. 50, Issue 3, Pages: 199-208(2019)
- 作者机构：
  
  南京大学化学化工学院　南京 210023
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2019.18191
  CLC：
- Published：2019-3，
  
  Published Online：30 October 2018，
  
  Received：30 August 2018，
  
  Revised：10 September 2018，
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Dan Zhang, Wei Wu, Xi-qun Jiang. Controllable Synthesis and Biological Properties of Unimolecular Polymer Nanomaterials. [J]. Acta Polymerica Sinica 50(3):199-208(2019)
DOI：

Dan Zhang, Wei Wu, Xi-qun Jiang. Controllable Synthesis and Biological Properties of Unimolecular Polymer Nanomaterials. [J]. Acta Polymerica Sinica 50(3):199-208(2019) DOI： 10.11777/j.issn1000-3304.2019.18191.

摘要

现代有机化学和高分子化学的发展为我们提供了多种高效可控的合成手段，例如点击化学、原子转移自由基聚合、可逆加成-断裂链转移聚合、开环易位聚合等. 综合利用这些合成手段，不同拓扑结构的单分子聚合物纳米材料可以被高效可控地合成. 本文主要介绍我们课题组近几年利用可控合成策略制备的几种不同类型的单分子聚合物纳米材料(包括环糊精聚轮烷、树枝状聚合物、多臂聚合物和聚合物分子刷)以及利用这些高分子纳米材料的高度可控性，对其结构与生物性能之间构效关系的探索.

Abstract

With the rapid development of modern organic chemistry and polymer chemistry

a variety of highly efficient and controllable synthetic methods have been discovered and applied extensively

such as click chemistry

atom transfer radical polymerization

reversible addition-fragmentation chain transfer polymerization

and ring-opening metathesis polymerization. Their comprehensive application has realized the controlled preparation of unimolecular polymer nanomaterials with well-designed topological structures

including cyclodextrane polyrotaxanes

dendrimers

multiarm star-shaped polymers

wormlike polymer brushes

etc

. Functioning as probes and drug carriers for disease diagnoses and treatments

respectively

these specifically fabricated materials are featured with such advantages as high designability

controllability

and stability of chemical structures

favorable reproducibility of pharmacokinetic and pharmacological profiles

great abundancy in reactive groups for multiple functionalization

and desirable ability to covalent-combine drugs for responsive targeted drug release. The highly controllable chemical structures of these unimolecular polymer nanomaterials make them the most suitable objects for studying the relationship between chemical and morphological structures and biological performance. Herein

the recent progress of our group is introduced

with specific focuses on the preparation of unimolecular polymer nanomaterials through controllable synthetic strategies

the precise control of their chemical structures and sizes

and the effect of their chemical structures and sizes on their

in vitro

and

in vivo

biological performance. The objectives of our research include cyclodextrane polyrotaxanes

dendrimers

multiarm star-shaped polymers

and wormlike polymer brushes

and their sizes range from several nanometers to dozens of nanometers. Based on our experiments

some important conclusions have been drawn as follows. Within the dimensional range between ten nanometers and dozens of nanometers

the size reduction of such nanomaterials favors higher cellular uptake

shorter blood circulation

as well as higher tumor accumulation and penetration. Besides

the nanomaterials with zwitterionic poly(carboxybetaine) (PCB) surface exhibit higher cellular uptake

longer blood circulation

and higher tumor accumulation and penetration than those with the poly(ethylene glycol) (PEG) surface do thanks to the surface-tethered phenylboronic acid groups. These results can be much conducive to the design of polymer nanocarriers for tumor diagnosis and therapy.

关键词

单分子聚合物纳米材料可控合成药物载体肿瘤治疗

Keywords

Unimolecular polymer nanomaterialsControllable synthesisDrug carriersTumor treatment

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Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

College of Chemistry and Chemical Engineering, Lanzhou University, State Key Laboratory of Applied Organic Chimestry

College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities

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