Protein Fibrillation in Neurodegenerative Diseases and Its Chiral Interaction with Interfaces

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Protein Fibrillation in Neurodegenerative Diseases and Its Chiral Interaction with Interfaces

Reviews | 更新时间：2021-01-26

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- Protein Fibrillation in Neurodegenerative Diseases and Its Chiral Interaction with Interfaces
- Acta Polymerica Sinica Vol. 50, Issue 6, Pages: 575-587(2019)
- 作者机构：
  
  1. 武汉理工大学化学化工与生命科学学院
  2. 材料复合新技术国家重点实验室　武汉 430070
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2019.18276
  CLC：
- Published：2019-6，
  
  Published Online：1 March 2019，
  
  Received：27 December 2018，
  
  Revised：22 January 2019，
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Qiang Yin, Jing-jing Liu, Meng-ting Tian, Hao Xie, Lei Shen, Tao-lei Sun. Protein Fibrillation in Neurodegenerative Diseases and Its Chiral Interaction with Interfaces. [J]. Acta Polymerica Sinica 50(6):575-587(2019)
DOI：

Qiang Yin, Jing-jing Liu, Meng-ting Tian, Hao Xie, Lei Shen, Tao-lei Sun. Protein Fibrillation in Neurodegenerative Diseases and Its Chiral Interaction with Interfaces. [J]. Acta Polymerica Sinica 50(6):575-587(2019) DOI： 10.11777/j.issn1000-3304.2019.18276.

摘要

神经退行性疾病(neurodegenerative diseases，NDs)的标志性病理特征是相关蛋白的错误折叠、聚集并纤维化，即淀粉样变性. 细胞膜界面在NDs病理过程中扮演了重要角色，这些过程包括NDs蛋白的产生、淀粉样单元的细胞内扩散、细胞间传播、细胞内吞及脑内清除. 因此，NDs蛋白与磷脂膜界面的相互作用显著影响蛋白纤维化和NDs病理过程. 手性是磷脂膜的基本化学属性，不同手性特征能产生不同生物物理效应. 因此，磷脂膜界面的手性特征会显著影响NDs蛋白纤维化以及NDs病理过程. 本文揭示了界面在NDs蛋白纤维化和NDs病理过程中的重要性，从分子水平重点阐述了界面的手性特征对NDs蛋白纤维化的影响，探讨了基于手性相互作用的NDs药物设计方法，有助于深入理解NDs病理机制，并对开发能够治愈NDs的药物具有重要意义.

Abstract

A hallmark event of neurodegenerative diseases (NDs) is the misfolding

aggregation and fibrillation of related proteins

namely amyloidosis. For example

amyloid-

β

(A

β

) and Tau

α

-synuclein (

α

-syn)

superoxide dismutase 1 (SOD1) and huntingtin exon 1 (HTTexon1) are tightly linked to Alzheimer’s Disease (AD)

Parkinson Disease (PD)

Amyotrophic Lateral Sclerosis (ALS) and Huntington ’s Disease (HD)

respectively. Plasma membrane plays a crucial role in the pathological processes of NDs

including the production

intracellular diffusion

intercellular transmission

endocytosis and clearance of NDs proteins and the resulting aggregates. Therefore

the interactions between NDs proteins and membrane interfaces significantly influence the protein fibrillation and NDs pathogenesis. Properties of membrane interfaces including amphiphilicity and charge density can influence the adsorption of proteins onto membranes and thus the protein folding and aggregation. As the basic chemical property of plasma membranes

chirality can determine key biophysical interactions. The alternation of molecule chirality can cause entirely different biophysical interactions and thus the biofunctions. From this biomimetic perspective

extensive works have demonstrated that the chirality of interfaces can significantly affect protein-surface interactions and thus the fibrillation processes. This brings us to reconsider the stereoselective interactions between NDs proteins and the chiral moieties on membrane interfaces and their impact during NDs pathogenesis. This review article is aimed to reveal the key role of membrane interfaces in protein fibrillation and discuss the impact of interfaces during NDs pathogenesis. The stereoselective protein-membrane interactions and their effects on protein fibrillation are elucidated from a molecular level. The designs of NDs drugs based on chiral interactions are also discussed. These specific aims will deepen our mechanistic insights into how interfaces affect NDs pathogenesis and facilitate the discovery of effective drugs for preventing protein fibrillation and eventually the cure of NDs.

关键词

神经退行性疾病蛋白纤维化界面手性

Keywords

Neurodegenerative diseasesProtein fibrillationInterfaceChirality

references

Riek R, Eisenberg D S . Nature , 2016 . 539 227 - 235 . DOI:10.1038/nature20416http://doi.org/10.1038/nature20416 .

Pannee J, Portelius E, Oppermann M, Atkins A, Hornshaw M, Zegers I, Hojrup P, Minthon L, Hansson O, Zetterberg H . Alzeimer’s Dis , 2013 . 33 1021 - 1032 . DOI:10.3233/JAD-2012-121471http://doi.org/10.3233/JAD-2012-121471 .

Li C Z, Gotz J . Nat Rev Drug Discov , 2017 . 16 863 - 883 . DOI:10.1038/nrd.2017.155http://doi.org/10.1038/nrd.2017.155 .

Goedert M . Nat Rev Neurosci , 2001 . 2 492 - 501 . DOI:10.1038/35081564http://doi.org/10.1038/35081564 .

Ruegsegger C, Maharjan N, Goswami A, Filezac L, Weis J, Troost D, Heller M, Gut H, Saxena S . Acta Neuropathol , 2016 . 131 427 - 451 . DOI:10.1007/s00401-015-1510-4http://doi.org/10.1007/s00401-015-1510-4 .

Ruiz-Arlandis G, Pieri L, Bousset L, Melki R . Neuropathol Appl Neurobiol , 2016 . 42 137 - 152 . DOI:10.1111/nan.2016.42.issue-2http://doi.org/10.1111/nan.2016.42.issue-2 .

Chiti F, Dobson C M . Annu Rev Biochem , 2006 . 75 333 - 366 . DOI:10.1146/annurev.biochem.75.101304.123901http://doi.org/10.1146/annurev.biochem.75.101304.123901 .

Goedert M . Science , 2015 . 349 1255555 DOI:10.1126/science.1255555http://doi.org/10.1126/science.1255555 .

Lorenzo A, Yankner B A . Proc Nat Acad Sci USA , 1994 . 91 12243 - 12247 . DOI:10.1073/pnas.91.25.12243http://doi.org/10.1073/pnas.91.25.12243 .

Kayed R, Head E, Thompson J L, McIntire T M, Milton S C, Cotman C W, Glabe C G . Science , 2003 . 300 486 - 489 . DOI:10.1126/science.1079469http://doi.org/10.1126/science.1079469 .

Makin S . Nature , 2018 . 559 S4 - S7 . DOI:10.1038/d41586-018-05719-4http://doi.org/10.1038/d41586-018-05719-4 .

Butterfield S M, Lashuel H . A, Angew Chem Int Ed , 2010 . 49 5628 - 5654 . DOI:10.1002/anie.v49:33http://doi.org/10.1002/anie.v49:33 .

Shrivastava A N, Aperia A, Melki R, Triller A . Neuron , 2017 . 95 33 - 50 . DOI:10.1016/j.neuron.2017.05.026http://doi.org/10.1016/j.neuron.2017.05.026 .

Baig A M . ACS Chem Neurosci , 2019 . 10 21 - 24 . DOI:10.1021/acschemneuro.8b00409http://doi.org/10.1021/acschemneuro.8b00409 .

Stopschinski B E, Diamond M I . Lancet Neurol , 2017 . 16 323 - 332 . DOI:10.1016/S1474-4422(17)30037-6http://doi.org/10.1016/S1474-4422(17)30037-6 .

Collinge J . Nature , 2016 . 539 217 - 226 . DOI:10.1038/nature20415http://doi.org/10.1038/nature20415 .

LaFerla F M, Green K N, Oddo S . Nat Rev Neurosci , 2007 . 8 499 - 509 . DOI:10.1038/nrn2168http://doi.org/10.1038/nrn2168 .

Strooper B D, Karran E . Cell , 2016 . 164 603 - 615 . DOI:10.1016/j.cell.2015.12.056http://doi.org/10.1016/j.cell.2015.12.056 .

Matsuzaki K . Biochim Biophys Acta , 2007 . 1768 1935 - 1942 . DOI:10.1016/j.bbamem.2007.02.009http://doi.org/10.1016/j.bbamem.2007.02.009 .

Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Schiossmacher M, Whaley J, Swindlehurst C, McCormack R, Wolfert R, Selkoe D, Lieberburg I, Schenk D . Nature , 1992 . 359 325 - 327 . DOI:10.1038/359325a0http://doi.org/10.1038/359325a0 .

Shen L, Adachi T, Vanden Bout D, Zhu X Y . J Am Chem Soc , 2012 . 134 14172 - 14178 . DOI:10.1021/ja305398fhttp://doi.org/10.1021/ja305398f .

Burke K A, Yates E A, Legleiter J . Front Neurol , 2013 . 4 1 - 17.

Mason S F . Nature , 1984 . 311 19 - 23 . DOI:10.1038/311019a0http://doi.org/10.1038/311019a0 .

Blackmond D G . Cold Spring Harb Perspect Biol , 2010 . 2 a002147 .

Bada J L . Method Enzymology , 1984 . 106 98 - 115 . DOI:10.1016/0076-6879(84)06011-0http://doi.org/10.1016/0076-6879(84)06011-0 .

Cintas P . Angew Chem Int Ed , 2002 . 41 1139 - 1145 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773 .

Koo E H, Squazzo S L . J Biol Chem , 1994 . 269 17386 - 17389.

Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F . Proc Natl Acad Sci USA , 2001 . 98 5815 - 5820 . DOI:10.1073/pnas.081612998http://doi.org/10.1073/pnas.081612998 .

Marquer C, Devauges V, Cossec J C, Liot G, Lecart S, Saudou F, Duyckaerts C, Leveque-Fort S, Potier M C . FASEB J , 2011 . 25 1295 - 1305 . DOI:10.1096/fj.10-168633http://doi.org/10.1096/fj.10-168633 .

Buffone M G, Verstraeten S V, Calamera J C, Doncel G F . J Androl , 2009 . 30 552 - 558 . DOI:10.2164/jandrol.108.006551http://doi.org/10.2164/jandrol.108.006551 .

Bodovitz S, Klein W L . J Biol Chem , 1996 . 271 4436 - 4440 . DOI:10.1074/jbc.271.8.4436http://doi.org/10.1074/jbc.271.8.4436 .

Thompson A G, Gray E, Heman-Ackah S M, Mager I, Talbot K, Andaloussi, S E, Wood M J, Turner M R . Nat Rev Neurol , 2016 . 8 1 - 12.

Arbor S C, LaFontaine M, Cumbay M . Yale J Biol Med , 2016 . 89 5 - 21.

Bharadwaj P, Solomon T, Malajczuk C J, Mancera R L, Howard M, Arrigan D W M, Newsholme P, Martins R N . Biochim Biophys Acta Biomembr , 2018 . 1860 1639 - 1651 . DOI:10.1016/j.bbamem.2018.03.015http://doi.org/10.1016/j.bbamem.2018.03.015 .

Kayed R, Sokolov Y, Edmonds B, Mclntire T M, Milton S C, Hall J E, Glabe C G . J Biol Chem , 2004 . 279 46363 - 46366 . DOI:10.1074/jbc.C400260200http://doi.org/10.1074/jbc.C400260200 .

Aisenbrey C, Borowik T, Bystrom R, Bokvist M, Lindstrom F, Misiak H, Sani M A, Grobner G . Eur Biophys J , 2008 . 37 247 - 255 . DOI:10.1007/s00249-007-0237-0http://doi.org/10.1007/s00249-007-0237-0 .

Ehehalt R, Keller P, Haass C, Thiele C, Simons K . J Cell Biol , 2003 . 160 113 - 123 . DOI:10.1083/jcb.200207113http://doi.org/10.1083/jcb.200207113 .

Riddell D R, Christie G, Hussain I, Dingwall C . Curr Biol , 2001 . 11 1288 - 1293 . DOI:10.1016/S0960-9822(01)00394-3http://doi.org/10.1016/S0960-9822(01)00394-3 .

Rausch J M, Marks J R, Rathinakumar R, Wimley W C . Biochemistry , 2007 . 46 12124 - 12130 . DOI:10.1021/bi700978hhttp://doi.org/10.1021/bi700978h .

Gonzalez M R, Bischofberger M, Pernot L, van der Goot F G, Freche B . Cell Mol Life Sci , 2008 . 65 493 - 507 . DOI:10.1007/s00018-007-7434-yhttp://doi.org/10.1007/s00018-007-7434-y .

Bechinger B, Lohner K . Biochim Biophys Acta Biomembr , 2006 . 1758 1529 - 1539 . DOI:10.1016/j.bbamem.2006.07.001http://doi.org/10.1016/j.bbamem.2006.07.001 .

Danzer K M, Haasen D, Karow A R, Moussaud S, Habeck M, Giese A, Kretzschmar H, Hengerer B, Kostka M . J Neurosci , 2007 . 27 9220 - 9232 . DOI:10.1523/JNEUROSCI.2617-07.2007http://doi.org/10.1523/JNEUROSCI.2617-07.2007 .

Lashuel H A . Sci Aging Konwl Environ , 2005 . 38 28 - 39.

Pearce M M P, Spartz E J, Hong W, Luo L, Kopito R R . Nat Commun , 2015 . 6 6768 DOI:10.1038/ncomms7768http://doi.org/10.1038/ncomms7768 .

Wong Y C, Krainc D . Nat Med , 2017 . 23 1 - 13.

Rajendran L, Honsho M, Zahn T R, Keller P, Geiger K D, Verkade P, Simons K. . Proc Natl Acad Sci USA , 2006 . 103 11172 - 11177 . DOI:10.1073/pnas.0603838103http://doi.org/10.1073/pnas.0603838103 .

Lee H J, Suk J E, Bae E J, Lee S J . Biochem Biophys Res Commun , 2008 . 372 423 - 428 . DOI:10.1016/j.bbrc.2008.05.045http://doi.org/10.1016/j.bbrc.2008.05.045 .

Yuyama K, Sun H, Mitsutake S, Igarashi Y . J Biol Chem , 2012 . 287 10977 - 10989 . DOI:10.1074/jbc.M111.324616http://doi.org/10.1074/jbc.M111.324616 .

Alvarez-Erviti L, Seow Y, Schapira A H, Gardiner C, Sargent I L, Wood M J A, Cooper J M. . Neurobiol Dis , 2011 . 42 360 - 367 . DOI:10.1016/j.nbd.2011.01.029http://doi.org/10.1016/j.nbd.2011.01.029 .

Saman S, Kim W H, Raya M, Visnick Y, Miro S, Saman S, Jackson B, McKee A C, Alvarez V E, Lee N C Y, Hall G F. . J Biol Chem , 2012 . 287 3842 - 3849 . DOI:10.1074/jbc.M111.277061http://doi.org/10.1074/jbc.M111.277061 .

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Kugler S, Ikezu T. . Nat Neurosci , 2015 . 18 1584 - 1593 . DOI:10.1038/nn.4132http://doi.org/10.1038/nn.4132 .

Munch C, O’Brien J, Bertolotti A . Proc Natl Acad Sci USA , 2011 . 108 3548 - 3553 . DOI:10.1073/pnas.1017275108http://doi.org/10.1073/pnas.1017275108 .

Kfoury N, Holmes B B, Jiang H, Holtzman D M, Diamond M I . J Biol Chem , 2012 . 287 19440 - 19451 . DOI:10.1074/jbc.M112.346072http://doi.org/10.1074/jbc.M112.346072 .

Wegmann S, Nicholls S, Takeda S, Fan Z, Hyman B T . J Neurochem , 2016 . 139 1163 - 1174 . DOI:10.1111/jnc.2016.139.issue-6http://doi.org/10.1111/jnc.2016.139.issue-6 .

Perrais D, Merrifield C J . Develop Cell , 2005 . 9 581 - 592 . DOI:10.1016/j.devcel.2005.10.002http://doi.org/10.1016/j.devcel.2005.10.002 .

Fiandaca M S, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz J B, Abner E L, Petersen R C, Federoff H J, Miller B L, Goetzl E J. . Alzheimers Dement , 2015 . 11 600 - 607 . DOI:10.1016/j.jalz.2014.06.008http://doi.org/10.1016/j.jalz.2014.06.008 .

Lobb R J, Becker M, Wen S W, Wong C S F, Wiegmans A P, Leimgruber A, Moller A. . J Extracell Vesicles , 2015 . 4 27031 DOI:10.3402/jev.v4.27031http://doi.org/10.3402/jev.v4.27031 .

Marcus M E, Leonard J N . Pharmaceuticals (Basel) , 2013 . 6 659 - 680 . DOI:10.3390/ph6050659http://doi.org/10.3390/ph6050659 .

Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood M J . Nat Biotechnol , 2011 . 29 341 - 345 . DOI:10.1038/nbt.1807http://doi.org/10.1038/nbt.1807 .

Wang H Y, Lee D H, D’Andrea M R, Peterson P A, Shank R P, Reitz A B . J Biol Chem , 2000 . 275 5626 - 5632 . DOI:10.1074/jbc.275.8.5626http://doi.org/10.1074/jbc.275.8.5626 .

Nagele R G, D’Andrea M R, Anderson W J, Wang H Y . Neuroscience , 2002 . 110 199 - 211 . DOI:10.1016/S0306-4522(01)00460-2http://doi.org/10.1016/S0306-4522(01)00460-2 .

Kim T, Vidal G S, Djurisic M, William C M, Birnbaum M E, Garcia K C, Hyman B T, Sharz C J . Science , 2013 . 341 1399 - 1404 . DOI:10.1126/science.1242077http://doi.org/10.1126/science.1242077 .

Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H . Proc Natl Acad Sci USA , 2015 . 112 E4465 - E4474 . DOI:10.1073/pnas.1421182112http://doi.org/10.1073/pnas.1421182112 .

Cisse M, Halabisky B, Harris J, Devidze N, Dubal D B, Sun B, Orr A, Lotz G, Kim D H, Hamto P . Nature , 2011 . 469 47 - 52 . DOI:10.1038/nature09635http://doi.org/10.1038/nature09635 .

Snyder E M, Nong Y, Almeida C G, Paul S, Moran T, Choi E Y, Nairn A C, Salter M W, Lombroso P J, Gouras G K, Greengard P . Nat Neurosci , 2005 . 8 1051 - 1058 . DOI:10.1038/nn1503http://doi.org/10.1038/nn1503 .

Lauren J, Gimbel D A, Nygaard H B, Gilbert J W, Strittmatter S M . Nature , 2009 . 457 1128 - 1132 . DOI:10.1038/nature07761http://doi.org/10.1038/nature07761 .

Renner M, Lacor P N, Velasco P T, Xu J, Contractor A, Klein W L, Triller A . Neuron , 2010 . 66 739 - 754 . DOI:10.1016/j.neuron.2010.04.029http://doi.org/10.1016/j.neuron.2010.04.029 .

Haas L T, Salazar S V, Kostylev M A, Um J W, Kaufman A C, Strittmatter S M . Brain , 2016 . 139 526 - 546 . DOI:10.1093/brain/awv356http://doi.org/10.1093/brain/awv356 .

Hu N W, Nicoll A J, Zhang D, Mably A J, O’Malley, T, Pirro S A, Terry C, Collinge J, Walsh D M, Rowan M J . Nat Commun , 2014 . 5 3374 DOI:10.1038/ncomms4374http://doi.org/10.1038/ncomms4374 .

Gomez-Ramos A, Diaz-Hernandez M, Rubio A, Miras-Portugal M T, Avila J . Mol Cell Neurosci , 2008 . 37 673 - 681 . DOI:10.1016/j.mcn.2007.12.010http://doi.org/10.1016/j.mcn.2007.12.010 .

Shrivastava A N, Redeker V, Fritz N, Pieri L, Almeida L G, Spolidoro M, Liebmann T, Bousset L, Renner M, Lena C . EMBO J , 2015 . 34 2408 - 2423 . DOI:10.15252/embj.201591397http://doi.org/10.15252/embj.201591397 .

Mao X, Ou M T, Karuppagounder S S, Kam T I, Yin X, Xiong Y, Ge P, Umanah G E, Brahmachari S, Shin J H . Science , 2016 . 353 3374 DOI:10.1126/science.aah3374http://doi.org/10.1126/science.aah3374 .

Bellani S, Mescola A, Ronzitti G, Tsushima H, Tilve S, Canale C, Valtorta F, Chieregatti E . Cell Death Differ , 2014 . 21 1971 - 1983 . DOI:10.1038/cdd.2014.111http://doi.org/10.1038/cdd.2014.111 .

Jackson K, Barisone G A, Diaz E, Jin L W, DeCarli C, Despa F . Ann Neurol , 2013 . 74 517 - 526 . DOI:10.1002/ana.v74.4http://doi.org/10.1002/ana.v74.4 .

Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, Verdile G . J Alzheimers Dis , 2017 . 59 421 - 432 . DOI:10.3233/JAD-161192http://doi.org/10.3233/JAD-161192 .

Tarasoff-Conway J M, Carare R O, Osorio R S, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic B V, Frangione B, Blennow K, Menard J, Zetterberg H, Wisniewski T, de Leon M J . Nat Rev Neurol , 2015 . 11 457 - 470 . DOI:10.1038/nrneurol.2015.119http://doi.org/10.1038/nrneurol.2015.119 .

Shibata M, Yamada S, Kumar S R, Calero M, Bading J, Frangione B, Holtzman D M, Miller C A, Strickland D K, Ghiso J, Zlokovic B V . J Clin Invest , 2000 . 106 1489 - 1499 . DOI:10.1172/JCI10498http://doi.org/10.1172/JCI10498 .

Liu C C, Liu C C, Kanekiyo T, Xu H, Bu G . Nat Rev Neurol , 2013 . 9 106 - 118 . DOI:10.1038/nrneurol.2012.263http://doi.org/10.1038/nrneurol.2012.263 .

Deane R, Du Yan S, Submamaryan R K, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt A M, Armstrong D L, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B . Nat Med , 2003 . 9 907 - 913 . DOI:10.1038/nm890http://doi.org/10.1038/nm890 .

Boland B, Wai H Y, Olga C, Bertrand M, Alexandre H, Erwan B, Olivier R M, Mark J M . Nat Rev Drug Dis , 2018 . 17 660 - 689 . DOI:10.1038/nrd.2018.109http://doi.org/10.1038/nrd.2018.109 .

Schilling M A . J Alzheimers Dis , 2016 . 51 961 - 977 . DOI:10.3233/JAD-150980http://doi.org/10.3233/JAD-150980 .

Duckworth W C, Bennett R G, Hamel F G . Endocr Rev , 1998 . 19 608 - 624.

Del Campo M, Stargardt A, Veerhuis R, Reits E, Teunissen C E. . Neurosci Lett , 2015 . 589 47 - 51 . DOI:10.1016/j.neulet.2015.01.036http://doi.org/10.1016/j.neulet.2015.01.036 .

Xie L, Helmerhorst E, Taddei K, Plewright B, van Bronswijk W, Martins R. . J Neurosci , 2002 . 22 RC221 - RC226 . DOI:10.1523/JNEUROSCI.22-10-j0001.2002http://doi.org/10.1523/JNEUROSCI.22-10-j0001.2002 .

Perez A, Morelli L, Cresto J C, Castano E M. . Neurochem Res , 2000 . 25 247 - 255 . DOI:10.1023/A:1007527721160http://doi.org/10.1023/A:1007527721160 .

Wilkinson K, El Khoury J . Int J Alzheimers Dis , 2012 . 2012 489456 .

Sevigny J, Chiao P, Bussiere T, Weinreb P H, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan M S, Quintero-Monzon O, Scannevin R H, Moore Arnold H, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch R M, Sandrock A. . Nature , 2016 . 537 50 - 70 . DOI:10.1038/nature19323http://doi.org/10.1038/nature19323 .

Brandenbury L O, Konrad M, Wruck C J, Koch T, Lucius R, Pufe T . J Neurochem , 2010 . 113 749 - 760 . DOI:10.1111/jnc.2010.113.issue-3http://doi.org/10.1111/jnc.2010.113.issue-3 .

Fujii N, Kaji Y, Fujii N . J Chromatogr B , 2011 . 879 3141 - 3147 . DOI:10.1016/j.jchromb.2011.05.051http://doi.org/10.1016/j.jchromb.2011.05.051 .

Nishikawa, T . J Chromatogr B , 2011 . 879 3169 - 3183 . DOI:10.1016/j.jchromb.2011.08.030http://doi.org/10.1016/j.jchromb.2011.08.030 .

Man E H, Sandhouse M E, Burg J, Fisher G H . Science , 1983 . 220 1407 - 1408 . DOI:10.1126/science.6857259http://doi.org/10.1126/science.6857259 .

Wiklund L, Toggenburger G, Cuenod M . Science , 1982 . 216 78 - 80 . DOI:10.1126/science.6121375http://doi.org/10.1126/science.6121375 .

Jonhson J W, Ascher P . Nature , 1987 . 325 529 - 530 . DOI:10.1038/325529a0http://doi.org/10.1038/325529a0 .

Suzuki M, Imanishi N, Mita M, Hamase K, Aiso S, Sasabe J . ASN Neuro , 2017 . 5 1 - 10.

Fisher G H, Payan I L, Chou S J, Man E H, Cerwinski S, Martin T, Emory C, Frey W H . Brain Res Bull , 1991 . 28 127 - 131.

Payan I L, Chou S J, Fisher G H, Man E H, Emory C, Frey W H . Neurochem Res , 1992 . 17 187 - 191 . DOI:10.1007/BF00966798http://doi.org/10.1007/BF00966798 .

Chouinard M, Gaitan D, Wood P . J Neurochem , 1993 . 61 1561 - 1564 . DOI:10.1111/jnc.1993.61.issue-4http://doi.org/10.1111/jnc.1993.61.issue-4 .

Lowe S L, Bowen D M, Francis P T, Toru M . Neurosci , 1990 . 38 571 - 577 . DOI:10.1016/0306-4522(90)90051-5http://doi.org/10.1016/0306-4522(90)90051-5 .

Sakai-Kato K, Naito M, Utsunomiya-Tate N . Biochem Biophys Res Commun , 2007 . 364 464 - 469 . DOI:10.1016/j.bbrc.2007.10.014http://doi.org/10.1016/j.bbrc.2007.10.014 .

Oda A, Kobayashi K, Takahashi O . Chem Biodiversity , 2010 . 7 1357 - 1363 . DOI:10.1002/cbdv.200900299http://doi.org/10.1002/cbdv.200900299 .

Roher A E, Lowenson J D, Clarke S, Wolkow C, Wang R, Cotter R J, Reardon I M, Zurcher-Neely H A, Heinrikson R L, Ball M J, Greenberg B D . J Biol Chem , 1993 . 268 3072 - 3083.

Wilson C C, Myles D, Ghosh M, Johnson L N, Wang W Q . New J Chem , 2005 . 29 1318 - 1322 . DOI:10.1039/b419295hhttp://doi.org/10.1039/b419295h .

Ollivaux C, Soyez D, Toullec J Y . J Peptide Sci , 2014 . 20 595 - 612 . DOI:10.1002/psc.v20.8http://doi.org/10.1002/psc.v20.8 .

Demarchi B, Collins M, Bergstrom E, Dowle A, Penkman K, Thomas-Oates J, Wilson J . Anal Chem , 2013 . 85 5835 - 5842 . DOI:10.1021/ac4005869http://doi.org/10.1021/ac4005869 .

Song X, Bao M, Li D, Li Y M . Mech Ageing Dev , 1999 . 108 239 - 251 . DOI:10.1016/S0047-6374(99)00022-6http://doi.org/10.1016/S0047-6374(99)00022-6 .

Wei H F, Li L, Song Q J, Ai H X, Chu J, Li W . Behav Brain Res , 2005 . 157 245 - 251 . DOI:10.1016/j.bbr.2004.07.003http://doi.org/10.1016/j.bbr.2004.07.003 .

Rehman S U, Shah S A, Ali T, Chung J I, Kim M O. . Mol Neurobiol , 2017 . 54 255 - 271 . DOI:10.1007/s12035-015-9604-5http://doi.org/10.1007/s12035-015-9604-5 .

Lu J, Wu D W, Zheng Y L, Hu B, Zhang Z F, Ye Q, Liu C M, Shan Q, Wang Y J . Cereb Cortex , 2010 . 20 2540 - 2548 . DOI:10.1093/cercor/bhq002http://doi.org/10.1093/cercor/bhq002 .

Yu Y, Bai F, Liu Y, Yang Y, Yuan Q, Zou D, Qu S, Tian G, Song L, Zhang T, Li S, Liu Y, Wang W, Ren G, Li D . Mol Cell Biochem , 2015 . 403 287 - 299 . DOI:10.1007/s11010-015-2358-6http://doi.org/10.1007/s11010-015-2358-6 .

Qing G Y, Zhao S L, Xiong Y T, Lv Z Y, Jiang F L, Liu Y, Chen H, Zhang M X, Sun T L . J Am Chem Soc , 2014 . 136 10736 - 10742 . DOI:10.1021/ja5049626http://doi.org/10.1021/ja5049626 .

Gao G B, Zhang M X, Lu P, Guo G, Wang D, Sun T L . Angew Chem Int Ed , 2015 . 54 2245 - 2250 . DOI:10.1002/anie.201410768http://doi.org/10.1002/anie.201410768 .

Malishev R, Arad E, Bhunia S K, Shaham-Niv S, Kolusheva S, Gazit E, Jelinek R . Chem Commun , 2018 . 54 7762 - 7767 . DOI:10.1039/C8CC03235Ahttp://doi.org/10.1039/C8CC03235A .

Wei W, Xu C, Gao N, Ren J S, Qu X G . Chem Sci , 2014 . 5 4367 - 4374 . DOI:10.1039/C4SC01386Ghttp://doi.org/10.1039/C4SC01386G .

Sen S, DasGupta S, DasGupta S . J Phys Chem C , 2017 . 121 18935 - 18946 . DOI:10.1021/acs.jpcc.7b05354http://doi.org/10.1021/acs.jpcc.7b05354 .

Wadai H, Yamaguchi K, Takahashi S, Kanno T, Kawai T, Naiki H, Goto Y . Biochemistry , 2005 . 44 157 - 164 . DOI:10.1021/bi0485880http://doi.org/10.1021/bi0485880 .

Dutta S, Foley A R, Warner C J A, Zhang X, Rolandi M, Abrams B, Raskatov J A . Angew Chem Int Ed , 2017 . 56 11506 - 11510 . DOI:10.1002/anie.201706279http://doi.org/10.1002/anie.201706279 .

Chalifour R J, McLaughlin R W, Lavoie L, Morissette C, Tremblay N, Boule M, Sarazin P, Stea D, Lacombe D, Tremblay P, Gervais F. . J Biol Chem , 2003 . 278 34874 - 34881 . DOI:10.1074/jbc.M212694200http://doi.org/10.1074/jbc.M212694200 .

Wiesehan K, Stohr J, Nagel-Steger L, van Groen T, Riesner D, Willbold D . Protein Eng Des Sel , 2008 . 21 241 - 246 . DOI:10.1093/protein/gzm054http://doi.org/10.1093/protein/gzm054 .

Leithold L H E, Jiang N, Post J, Ziehm T, Schartmann E, Kutzsche J, Jon Shah N, Breitkreutz J, Langen K J, Willuweit A, Willbold D. . Pharm Res , 2016 . 33 328 - 336 . DOI:10.1007/s11095-015-1791-2http://doi.org/10.1007/s11095-015-1791-2 .

Guan Y J, Du Z, Gao N, Cao Y, Wang X H, Scott P, Song H L, Ren J S, Qu X G. . Sci Adv , 2018 . 4 eaao6718 DOI:10.1126/sciadv.aao6718http://doi.org/10.1126/sciadv.aao6718 .

Sood A, Abid M, Hailemichael S, Foster M, Török B, Török M . Bioorg Med Chem Lett , 2009 . 19 6931 - 6934 . DOI:10.1016/j.bmcl.2009.10.066http://doi.org/10.1016/j.bmcl.2009.10.066 .

Wang Y X, Zhou L, Wang J, Lin B, Wang X B, Huang X X, Song S J . Bioorg Chem , 2018 . 77 579 - 585 . DOI:10.1016/j.bioorg.2018.02.001http://doi.org/10.1016/j.bioorg.2018.02.001 .

Root-Bernstein R S, Holsworth D D . J Theor Biol , 1998 . 190 107 - 119 . DOI:10.1006/jtbi.1997.0544http://doi.org/10.1006/jtbi.1997.0544 .

Heal J R, Roberts G W, Christie G, Miller A D . ChemBioChem , 2002 . 3 86 - 92 . DOI:10.1002/(ISSN)1439-7633http://doi.org/10.1002/(ISSN)1439-7633 .

Evers M M, Toonen L J A, van Roon-Mom W M C . Adv Drug Del Rev , 2015 . 87 90 - 103 . DOI:10.1016/j.addr.2015.03.008http://doi.org/10.1016/j.addr.2015.03.008 .

Baker S K, Chen Z L, Norris E H, Revenko A S, MacLeod A R, Strickland S . Proc Natl Acad Sci USA , 2018 . 115 E9687 - E9696 . DOI:10.1073/pnas.1811172115http://doi.org/10.1073/pnas.1811172115 .

Engel M F M, van den Akker C C, Schleeger M, Velikov K P, Koenderink G H, Bonn M . J Am Chem Soc , 2012 . 134 14781 - 14788 . DOI:10.1021/ja3031664http://doi.org/10.1021/ja3031664 .

Galvagnion C . J Parkinson’s Dis , 2017 . 7 433 - 450 . DOI:10.3233/JPD-171103http://doi.org/10.3233/JPD-171103 .

Yang M, Wang K, Lin J, Wang L, Wei F, Zhu J, Zheng W, Shen L . Langmuir , 2018 . 34 8408 - 8414 . DOI:10.1021/acs.langmuir.8b01315http://doi.org/10.1021/acs.langmuir.8b01315 .

Ikeda K, Matsuzaki K . Biochem Biophys Res Commun , 2008 . 370 525 - 529 . DOI:10.1016/j.bbrc.2008.03.130http://doi.org/10.1016/j.bbrc.2008.03.130 .

Rangachari V, Dean D N, Rana P, Vaidya A, Ghosh P . Biochim Biophy Acta Biomembr , 2018 . 1860 1652 - 1662 . DOI:10.1016/j.bbamem.2018.03.004http://doi.org/10.1016/j.bbamem.2018.03.004 .

Hong S, Beja-Glasser V F, Nfonoyim B M, Frouin A, Li S, Ramakrishnan S, Merry K M, Shi Q, Rosenthal A, Barres B A . Science , 2016 . 352 712 - 716 . DOI:10.1126/science.aad8373http://doi.org/10.1126/science.aad8373 .

Liebmann T, Renier N, Bettayeb K, Greengard P, Tessier-Lavigne M, Flajolet M . Cell Rep , 2016 . 16 1138 - 1152 . DOI:10.1016/j.celrep.2016.06.060http://doi.org/10.1016/j.celrep.2016.06.060 .

Ulmschneider J P, Ulmschneider M B . Acc Chem Res , 2018 . 51 1106 - 1116 . DOI:10.1021/acs.accounts.7b00613http://doi.org/10.1021/acs.accounts.7b00613 .

Press-Sandler O, Miller Y . Biochim Biophys Acta Biomembr , 2018 . 1860 1889 - 1905 . DOI:10.1016/j.bbamem.2018.03.014http://doi.org/10.1016/j.bbamem.2018.03.014 .

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