Catalytic System for Superfast Polypeptide Synthesis under Atmosphere Condition

Xin-hua Wan; Xian-hong Wang

doi:10.11777/j.issn1000-3304.2019.19006

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Catalytic System for Superfast Polypeptide Synthesis under Atmosphere Condition

Research Highlights | 更新时间：2021-01-26

- Catalytic System for Superfast Polypeptide Synthesis under Atmosphere Condition
- Acta Polymerica Sinica Vol. 50, Issue 2, Pages: 99-101(2019)
- 作者机构：
  
  1.北京分子科学国家研究中心高分子化学与物理教育部重点实验室北京大学化学与分子工程学院　北京 100871
  2.中国科学院长春应用化学研究所　长春 130022
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2019.19006
  CLC：
- Published：2019-2，
  
  Published Online：17 January 2019，
  
  Received：10 January 2019，
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Xin-hua Wan, Xian-hong Wang. Catalytic System for Superfast Polypeptide Synthesis under Atmosphere Condition. [J]. Acta Polymerica Sinica 50(2):99-101(2019)
DOI：

Xin-hua Wan, Xian-hong Wang. Catalytic System for Superfast Polypeptide Synthesis under Atmosphere Condition. [J]. Acta Polymerica Sinica 50(2):99-101(2019) DOI： 10.11777/j.issn1000-3304.2019.19006.

摘要

聚肽(

-氨基酸聚合物)具有优异的生物相容性、良好的生物活性和全生物降解性，是最受关注的生物医用高分子材料之一. 最常见的聚肽合成方法是伯胺引发的

-羧基环内酸酐(NCA)的开环聚合，但该方法对水分特别敏感，且反应速度慢，容易发生副反应，难以获得高分子量聚肽. 最近，华东理工大学的刘润辉团队巧妙采用六甲基二硅基胺基锂(LiHMDS)为催化剂引发NCA开环聚合，首次实现了空气氛下NCA开环活性聚合，反应在几分钟到几小时内即可完成，并获得数均分子量超过2.8 × 10

g/mol的聚谷氨酸，开创了聚肽的简易、快速高效合成路线，为聚肽在生物医用材料上的规模应用奠定了重要基础.

Abstract

Polypeptides (

-amino acid polymers)

as one of the most promising biomedical polymers

have excellent biocompatibility

bioactivities and biodegradability. Primary amine-initiated NCA polymerization is the most widely used method to prepare polypeptides. However

this polymerization is super sensitive to moisture

with slow reaction rate and side reactions

and difficult to obtain polypeptides with high molecular weight. Recently

Prof. Liu

et al

. at East China University of Science and Technology utilized Lithium Hexamethyldisilazide (LiHMDS) as the catalyst to initiate ring opening polymerization of NCA. This is the first demonstration of moisture insensitive NCA polymerization under atmosphere condition. This NCA polymerization can be completed within a few minutes to a few hours and successfully produces poly-BLG with number average molecular weight over 2.8 × 10

g/mol. This research opens the era for easy and efficient synthesis of polypeptides and builds the foundation for large-scale application of polypeptides as biomedical materials.

关键词

聚肽N-羧基环内酸酐(NCA)超快聚合空气氛

Keywords

PolypeptidesN-Carboxyanhydrides (NCA)Superfast polymerizationAtmosphere condition

references

Leuchs H . Ber Dtsch Chem Ges , 1906 . 39 857 - 861 . DOI:10.1002/(ISSN)1099-0682http://doi.org/10.1002/(ISSN)1099-0682 .

Kricheldorf H R . Angew Chem Int Ed , 2006 . 45 ( 35 ): 5752 - 5784 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773 .

Cheng J J, Deming T J . Peptide-Based Materials , 2012 . 310 1 - 26.

Song Z Y, Han Z Y, Lv S X, Chen C Y, Chen L, Yin L C, Cheng J J . Chem Soc Rev , 2017 . 46 ( 21 ): 6570 - 6599 . DOI:10.1039/C7CS00460Ehttp://doi.org/10.1039/C7CS00460E .

Wu Y M, Zhang D F, Ma P C, Zhou R Y, Hua L, Liu R H . Nat Commun , 2018 . 9 ( 1 ): 5297 DOI:10.1038/s41467-018-07711-yhttp://doi.org/10.1038/s41467-018-07711-y .

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School of Materials Science and Engineering, East China University of Science and Technology

School of Materials Science and Engineering, East China University of Science and Technology, Shanghai Key Laboratory of Advanced Polymeric Materials

Department of Materials Science, Fudan University

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