DNA-assisted High-efficient Purifying and Encoding of Gold Nanotriangles

Shuang Lu; Wei-na Fang; Li-hua Wang; Hua-jie Liu

doi:10.11777/j.issn1000-3304.2019.19049

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DNA-assisted High-efficient Purifying and Encoding of Gold Nanotriangles

Research Article | 更新时间：2021-01-26

- DNA-assisted High-efficient Purifying and Encoding of Gold Nanotriangles
- Acta Polymerica Sinica Vol. 50, Issue 9, Pages: 964-972(2019)
- 作者机构：
  
  1.中国科学院上海应用物理研究所　上海 201800
  2.中国科学院大学　北京 100049
  3.上海交通大学医学院附属仁济医院分子医学研究院　上海 200127
  4.同济大学化学科学与工程学院　上海 200092
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2019.19049
  CLC：
- Published：2019-9，
  
  Published Online：5 May 2019，
  
  Received：11 March 2019，
  
  Revised：22 March 2019，
扫描看全文
Shuang Lu, Wei-na Fang, Li-hua Wang, Hua-jie Liu. DNA-assisted High-efficient Purifying and Encoding of Gold Nanotriangles. [J]. Acta Polymerica Sinica 50(9):964-972(2019)
DOI：

Shuang Lu, Wei-na Fang, Li-hua Wang, Hua-jie Liu. DNA-assisted High-efficient Purifying and Encoding of Gold Nanotriangles. [J]. Acta Polymerica Sinica 50(9):964-972(2019) DOI： 10.11777/j.issn1000-3304.2019.19049.

摘要

针对目前纳米金三角片的分离纯化手段仍不够成熟这一问题，提出借助巯基修饰的DNA分子，对混有类球形颗粒等杂质的纳米金三角片粗产物，进行形状选择性分离纯化的新思路. 纳米金表面修饰的DNA分子，一方面屏蔽了金与溶液环境的直接接触，提高了颗粒的稳定性；另一方面，形貌粒径以及表面DNA修饰量的差异，造成不同纳米金颗粒在电场中的迁移速度不同，因而可通过凝胶电泳手段分离纯化金颗粒. 该方法获得的纳米金三角片纯度在80%以上，并对于不同粒径的三角片纯化具有普适性. 更为重要的是，表面修饰的DNA同时实现了对纳米金三角片的信息编码，通过设计修饰DNA序列信息，可以实现后续的可控组装，构建更高级结构.

Abstract

Combining the advantages of information encoding and function realization

DNA-conjugated nanomaterials have attracted great attention recently. As a typical anisotropic material

gold nano-triangle is of great value due to the sharp vertices. However

the yield of nano-triange is not high through current wet synthesis. In order to solve this problem

we propose a new strategy of shape selective separation of gold nano-triangles with the assist of thiol-DNA. The attachment of DNA to the surface of gold nanoparticles

on one hand

can stabilize the nanoparticles by shielding the direct contact between gold nanoparticles and solution environment. On the other hand

according to the particle shape

size and the surface charge density

gold nanoparticles have different mobilities in the electric field. As a result

gold nanoparticles can be separated by gel electrophoresis. The DNA-assist purification method gives a yield of above 80% of gold nano-triangles

which is also universal for the separation of nano-triangles with different sizes. More importantly

the surface-modified DNA can simultaneously separate and encode gold nano-triangles. By rational designing the DNA sequence

nano-triangles can be assembled on DNA origami and higher-order structures can be constructed.

关键词

纳米金颗粒金三角片DNA自组装电泳纯化

Keywords

Gold nanoparticlesGold nanotrianglesDNASelf-assemblyEelectrophoresisPurification

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School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University

Shanghai Advanced Research Institute, Chinese Academy of Sciences

State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology

Department of Polymer Science and Engineering, University of Massachusetts, Amherst

Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology

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