Synthesis of Oxidation Responsive Vesicles with Different Block Sequences <italic style="font-style: italic">via</italic> RAFT Polymerization-induced Self-assembly

Jin-wen Zheng; Xiao Wang; Ze-sheng An

doi:10.11777/j.issn1000-3304.2019.19070

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Synthesis of Oxidation Responsive Vesicles with Different Block Sequences via RAFT Polymerization-induced Self-assembly

Research Article | 更新时间：2021-01-26

- Synthesis of Oxidation Responsive Vesicles with Different Block Sequences via RAFT Polymerization-induced Self-assembly
  增强出版
- Acta Polymerica Sinica Vol. 50, Issue 11, Pages: 1167-1176(2019)
- 作者机构：
  
  1.上海大学环境与化学工程学院纳米化学与生物学研究所　上海 200444
  2.吉林大学化学学院超分子结构与材料国家重点实验室　长春 130012
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2019.19070
  CLC：
- Published：2019-11，
  
  Published Online：8 July 2019，
  
  Received：9 April 2019，
  
  Revised：3 June 2019，
扫描看全文
Jin-wen Zheng, Xiao Wang, Ze-sheng An. Synthesis of Oxidation Responsive Vesicles with Different Block Sequences via RAFT Polymerization-induced Self-assembly. [J]. Acta Polymerica Sinica 50(11):1167-1176(2019)
DOI：

Jin-wen Zheng, Xiao Wang, Ze-sheng An. Synthesis of Oxidation Responsive Vesicles with Different Block Sequences via RAFT Polymerization-induced Self-assembly. [J]. Acta Polymerica Sinica 50(11):1167-1176(2019) DOI： 10.11777/j.issn1000-3304.2019.19070.

摘要

以聚

-二甲基丙烯酰胺(PDMA)为大分子链转移剂(macro-CTA)，双丙酮丙烯酰胺(DAAM)和

-丙烯酰硫吗啉(NAT)为单体，在水和二氧六环的混合溶剂中，通过聚合诱导自组装(PISA)制备了3种不同嵌段序列的聚合物纳米颗粒，分别为PDMA-PNAT-PDAAM，PDMA-PDAAM-PNAT以及PDMA-P(NAT-

-DAAM). 核磁共振氢谱(

H-NMR)表明单体转化率在5 h内接近100%. 通过凝胶渗透色谱(GPC)对聚合物相对分子量及分子量分布进行了表征. 通过透射电子显微镜(TEM)研究了嵌段共聚物纳米颗粒的形貌转化过程以及3种聚合物囊泡在双氧水溶液中的氧化响应行为. 这种具有氧化响应性的聚合物囊泡有望为药物输送和控制释放提供合适的载体.

Abstract

Block copolymer (BCP) nanoparticles with three different block sequences

PDMA-PNAT-PDAAM (M-N-D)

PDMA-PDAAM-PNAT (M-D-N) and PDMA-P(NAT-

-DAAM) (M-[N-

-D])

are prepared

via

polymerization-induced self-assembly (PISA). Soluble

-acryloyloxy thiomorpholine (NAT) and diacetone acrylamide (DAAM) are used as monomers to form insoluble core blocks in water

while PDMA

bearing a trithiocarbonate is utilized as stabilizer and macromolecular chain transfer agent (macro-CTA) to render a RAFT control. Specifically

M-[N-

-D] nano-objects are synthesized

via

direct RAFT dispersion copolymerization of NAT and DAAM at 70 °C employing PDMA

macro-CTA. To produce M-N-D and M-D-N triblock copolymers

PDMA-PNAT (M-N) and PDMA-PDAAM (M-D) nano-objects are prepared

via

RAFT dispersion PISA syntheses of NAT and DAAM respectively utilizing PDMA

macro-CTA and then used for seeded dispersion polymerization of DAAM and NAT respectively without intermediate postpolymerization purification. The thioether moiety in NAT can be oxidized by reactive oxygen species (ROS) into a hydrophilic sulfoxide. Therefore

in the precense of hydrogen peroxide (H

)

oxidation-responsive morphological degradation of these nano-objects occurs due to the increasing hydrophilicity of NAT units. Given the poor control over polymerization of NAT in pure water

4-dioxane is used as a cosolvent to the PNAT block. So the PISA syntheses are conducted in water/1

4-dioxane (9/1

) mixture to achieve a good control over the molecular weight and narrow distribution.

H-NMR spectra indicate that quantitative monomer conversions (

99%) are achieved within 5 h. Differential scanning calorimeter (DLS) and transmission electron microscopy (TEM) are used to characterize final morphologies of PISA-generated nano-objects and morphological evolution of nano-objects in the presence of H

(10 mol/L). These aqueous sequence-controlled PISA formulations are expected to provide responsive nanoparticles with tunable kinetics due to the response-dependent morphological transitions

which may be potentially used as carriers for drug delivery and controlled release.

关键词

聚合诱导自组装氧化响应聚合物囊泡嵌段序列

Keywords

Polymerization-induced self-assemblyOxidation-responsivePolymer vesiclesBlock sequence

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⁰

Synthesis of Oxidation Responsive Vesicles with Different Block Sequences via RAFT Polymerization-induced Self-assembly

DOI：10.11777/j.issn1000-3304.2019.19070

摘要

Abstract

关键词

Keywords

references