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Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines
- Acta Polymerica Sinica Vol. 51, Issue 2, Pages: 125-135(2020)
- 作者机构：
中国科学院过程工程研究所 生化工程国家重点实验室 北京 100190
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2019.19143
CLC：Published：2020-2，
Published Online：6 November 2019，
Received：2 August 2019，
Revised：12 September 2019，
扫 描 看 全 文
Hua Yue, Guang-hui Ma. Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines. [J]. Acta Polymerica Sinica 51(2):125-135(2020)
Hua Yue, Guang-hui Ma. Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines. [J]. Acta Polymerica Sinica 51(2):125-135(2020) DOI： 10.11777/j.issn1000-3304.2019.19143.
摘要
随着新发、突发重大传染病以及恶性肿瘤等疾病防控需求的增加，以经验开发为主的传统疫苗体系亟待更新. 高分子纳微球因其独特的理化优势，成为生物医药递送领域研究和关注的焦点. 但是如何对纳微球体系进行合理化设计和工程化整合是疫苗递送系统开发中遇到的重要挑战. 本团队20年来在高分子纳微球制备和应用方面进行了系统性研究，并提出纳微球为“底盘”(Chassis)和亚单位疫苗共组装成先进疫苗的策略，发现和创制了高分子纳微球新功能，阐明了其在细胞/黏膜免疫中的重要作用机理. 本专论结合国内外研究现状，围绕上述研究工作，介绍了工程化疫苗底盘按需设计的思路和参考机制，同时也探讨了其在生物医药领域的发展前景.
Abstract
With the increasing demand for preventing and controlling of new/sudden diseases
major infectious diseases and malignant tumors
vaccines that based on traditional experience await updated. In terms of the unique physio-chemical advantages
polymeric micro/nano particles have become the research hotspots in the field of biomedical delivery. However
the rational integration of the micro/nano particles into vaccine delivery system is a huge challenge. On the basis of our research on the preparation and application of polymer micro/nano particles
an advanced strategy that co-assembles the particle “chassis” and subunit vaccines into one engineered vaccine is proposed. During the 20-year systematic study
new functions of polymeric particles are developed
and important mechanisms for the enhanced cellular/mucosal immunity are clarified. Apart from the chassis with conventional physiochemical property
other chassises with lysosomal escape merit
unique properties (deformability or mobility)
or “Immunoticket” advantage have been exploited. The present paper not only summarizes our work but also involves international research progress
which sheds light upon the engineered vaccine chassises for their on-demand design concept
relative mechanism and development.
关键词
高分子纳微球颗粒底盘工程化疫苗细胞免疫黏膜免疫
Keywords
Polymer micro/Nano particlesParticle chassisEngineered vaccineCellular immunityMucosal immunity
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