Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels

Yong-san Li; Yan-shuang Xu; Lei Tao; Yen Wei

doi:10.11777/j.issn1000-3304.2020.19144

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Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels

更新时间：2021-04-27

- Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels
- Acta Polymerica Sinica Vol. 51, Issue 1, Pages: 30-38(2020)
- 作者机构：
  
  生命有机磷化学教育部重点实验室清华大学化学系　北京 100084
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2020.19144
  CLC：
- Published：2020-1，
  
  Published Online：14 October 2019，
  
  Received：2 August 2019，
  
  Revised：29 August 2019，
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Yong-san Li, Yan-shuang Xu, Lei Tao, Yen Wei. Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels. [J]. Acta Polymerica Sinica 51(1):30-38(2020)
DOI：

Yong-san Li, Yan-shuang Xu, Lei Tao, Yen Wei. Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels. [J]. Acta Polymerica Sinica 51(1):30-38(2020) DOI： 10.11777/j.issn1000-3304.2020.19144.

摘要

自愈性水凝胶作为一种新型仿生智能材料受到了科研人员的广泛关注. 近年来，人们利用动态共价键、超分子作用，发展了一系列自愈性水凝胶，并将其应用于药物控释、细胞三维培养、组织工程等生物医用领域. 本文总结和评述了基于动态共价键的自愈性水凝胶及这些水凝胶作为药物载体的相关研究，并展望了基于动态化学的自愈性水凝胶的未来发展.

Abstract

Self-healing hydrogel is a new generation smart material that has drawn great attention among researchers from multiple cutting edge areas. Self-healing hydrogels are continuously enriching our knowledge in developing new materials and changing our lives. In the recent decades

thanks to numerous dedicated researchers

series of self-healing hydrogels have been explored through dynamic chemistry and supramolecular interactions

which have been applied in interdisciplinary areas for controlled release of drugs

3D cell culture

and scaffolds of tissue engineering

etc

. Self-healing hydrogels can be injected as solid gels instead of liquid precursor

then self-heal

in situ

. Thus

self-healing hydrogels have been utilized as a new type of injectable carrier to deliver drugs. This method effectively avoids unwanted cargo loss throughout the cycling and dramatically improves the delivery efficiency of drugs. Thus

self-healing hydrogels have been studied in recent research as great therapeutic carrier for tumour therapy and wound-healing. This review aims to summarize some recent research progresses in the preparation of self-healing hydrogels based on different dynamic covalent bonds. The bio-medical applications of self-healing hydrogels including tumour therapy and wound-healing have also been introduced. The future development and challenges of dynamic chemistry based on self-healing hydrogels have also been discussed.

关键词

动态共价键自愈性水凝胶药物载体

Keywords

Dynamic covalent bondSelf-healing hydrogelDrug carrier

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