Polymeric Materials for the Regulation of Tumor Immune Microenvironment

Wei-min Miao; Jia-si Wu; Qi-song Tong; Yong-cong Huang; Jin-zhi Du

doi:10.11777/j.issn1000-3304.2020.19227

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Polymeric Materials for the Regulation of Tumor Immune Microenvironment

更新时间：2021-01-26

- Polymeric Materials for the Regulation of Tumor Immune Microenvironment
- Acta Polymerica Sinica Vol. 51, Issue 5, Pages: 548-558(2020)
- 作者机构：
  
  1.华南理工大学生物科学与工程学院　
  2. 广州国际校区生物医学科学与工程学院　
  3. 生命科学研究院　
  4. 国家人体组织功能重建工程技术研究中心　广州 510006
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2020.19227
  CLC：
- Published：2020-5，
  
  Published Online：26 April 2020，
  
  Received：30 December 2019，
  
  Revised：27 February 2020，
扫描看全文
Wei-min Miao, Jia-si Wu, Qi-song Tong, Yong-cong Huang, Jin-zhi Du. Polymeric Materials for the Regulation of Tumor Immune Microenvironment. [J]. Acta Polymerica Sinica 51(5):548-558(2020)
DOI：

Wei-min Miao, Jia-si Wu, Qi-song Tong, Yong-cong Huang, Jin-zhi Du. Polymeric Materials for the Regulation of Tumor Immune Microenvironment. [J]. Acta Polymerica Sinica 51(5):548-558(2020) DOI： 10.11777/j.issn1000-3304.2020.19227.

摘要

随着肿瘤免疫疗法在临床应用取得巨大突破，通过抗肿瘤免疫反应提高抗肿瘤疗效的治疗方式受到了广泛的关注. 然而，肿瘤组织存在复杂的免疫抑制性微环境，严重限制了部分免疫疗法的效果. 长期以来，高分子材料作为重要的药物递送载体受到广泛关注，但是其在调控肿瘤免疫微环境的功能及应用方面尚未引起足够的重视. 在本文中，我们一方面介绍了肿瘤组织形成免疫抑制性微环境的成因，如肿瘤组织存在多种免疫抑制性细胞，如调节性T细胞(Tregs)、髓系来源抑制性细胞(MDSCs)和肿瘤相关巨噬细胞(TAMs)等，以及免疫细胞、肿瘤细胞等分泌的大量细胞因子、趋化因子、代谢产物等. 另一方面，重点介绍了近年来高分子材料作为载体递送免疫调节分子或发挥自身免疫调节功能，调控或逆转免疫抑制性微环境的策略和典型代表，证明了高分子材料在调控肿瘤免疫微环境，改善肿瘤治疗效果方面的巨大潜力.

Abstract

With great success of cancer immunotherapy in clinical practice

extensive attentions have been attracted to improve the efficacy of anti-tumor therapy by inducing anti-tumor immune response. However

there exists a complicated immunosuppressive tumor microenvironment within tumor tissue

which severely reduces the effectiveness of cancer immunotherapy. For a long period of time

polymeric materials have been used as important drug delivery carriers

but their applications in the regulation of tumor immune microenvironment are still in an infant stage. In this review

we described the characteristics of tumor immune microenvironment

which includes the presence of a variety of immune suppressive cells

such as regulatory T cells (Tregs)

myeloid-derived suppressor cells (MDSCs) and tumor associated macrophage (TAMs)

etc

as well as large amounts of cytokines and chemokines

metabolites

etc

. secreted by immune cells and tumor cells. Then

we systemically summarized the strategies of polymeric materials in the regulation of tumor immunosuppressive environment

including enhancing tumor immunogenicity

regulating immunosuppressive cells

and cytokines as well as combination therapy. In the end

we discussed the perspective and challenges for advanced design of polymeric materials to regulate the tumor immune microenvironment

and concluded that by regulating or reversing the immunosuppressive microenvironment

anti-tumor efficacy can be effectively improved.

关键词

高分子材料肿瘤免疫微环境免疫治疗药物递送

Keywords

Polymeric materialsTumor immune microenvironmentImmunotherapyDrug delivery

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