Enhancement of Nonleaching Antimicrobial Poly(vinyl alcohol)/Poly(hexamethylene guanidine) Hydrogels

Wu-ling Gong; Da-fu Wei; Shao-tian Zhang; Jing-yun Ye; An-na Zheng; Yong Guan

doi:10.11777/j.issn1000-3304.2020.20080

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Enhancement of Nonleaching Antimicrobial Poly(vinyl alcohol)/Poly(hexamethylene guanidine) Hydrogels

更新时间：2021-01-26

- Enhancement of Nonleaching Antimicrobial Poly(vinyl alcohol)/Poly(hexamethylene guanidine) Hydrogels
- Acta Polymerica Sinica Vol. 51, Issue 12, Pages: 1347-1355(2020)
- 作者机构：
  
  上海市先进聚合物材料重点实验室华东理工大学材料科学与工程学院　上海 200237
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2020.20080
  CLC：
- Published：21 October 2020，
  
  Published Online：29 June 2020，
  
  Received：23 March 2020，
  
  Revised：14 April 2020，
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Wu-ling Gong, Da-fu Wei, Shao-tian Zhang, Jing-yun Ye, An-na Zheng, Yong Guan. Enhancement of Nonleaching Antimicrobial Poly(vinyl alcohol)/Poly(hexamethylene guanidine) Hydrogels. [J]. Acta Polymerica Sinica 51(12):1347-1355(2020)
DOI：

Wu-ling Gong, Da-fu Wei, Shao-tian Zhang, Jing-yun Ye, An-na Zheng, Yong Guan. Enhancement of Nonleaching Antimicrobial Poly(vinyl alcohol)/Poly(hexamethylene guanidine) Hydrogels. [J]. Acta Polymerica Sinica 51(12):1347-1355(2020) DOI： 10.11777/j.issn1000-3304.2020.20080.

摘要

通过冻融法制备了非溶出型的抗菌聚乙烯醇/聚己基胍盐酸盐(PVA/PHMG)水凝胶. 傅里叶红外光谱测试结果表明：PHMG的胺基与PVA的羟基之间存在明显的氢键作用，这种作用赋予了PHMG非溶出性. PVA/PHMG水凝胶有非常优异的抗菌效果，并且拉伸强度为PVA水凝胶的2.2倍. 进一步分别以氧化石墨烯(GO)和二氧化硅(SiO

)为增强剂，制备了PVA/PHMG/GO水凝胶和PVA/PHMG/SiO

水凝胶. 2种复合水凝胶同样显示非溶出性抗菌性能；抗菌率在99.99%以上，水洗或在水中浸泡7天后抗菌率未降低. GO、SiO

与PVA/PHMG形成氢键，显著增强了水凝胶的拉伸强度. PVA/PHMG/GO和 PVA/PHMG/SiO

水凝胶的拉伸强度分别是PVA/PHMG水凝胶的1.6倍和3.3倍.

Abstract

A novel nonleaching antimicrobial poly(vinyl alcohol)/poly(hexamethylene guanidine) hydrochloride (PVA/PHMG) hydrogel was prepared with freezing-thawing method. The hydrogen bond interaction between PVA and PHMG confirmed by ATR-FTIR spectra

endowed PVA/PHMG hydrogels with the nonleaching characteristic. These antimicrobial hydrogels behaved above 99.9% of antimicrobial rates against both

E. coli

and

S. aureus

even after washing or soaking in water for 7 days. The PVA-0.100wt%PHMG hydrogel had 120% higher tensile strength than pure PVA hydrogel due to the reinforement of hydrogen bonding between PVA and PHMG. Furthermore

GO (graphene oxide) and SiO

were respectively added to the PVA-0.100wt% PHMG system to reinforce the mechanical properties. PVA/PHMG/GO hydrogel and PVA/PHMG/SiO

hydrogel were also prepared

via

freezing-thawing method. These two composite hydrogels still showed nonleaching antimicrobial properties and the antimicrobial rates were above 99.99% even after washing or soaking in water for 7 days. Compared with PVA/PHMG hydrogel

the ―OH peak of the PVA/PHMG/SiO

hydrogels in the infrared difference spectra shifted to the lower wavenumbers by 38 cm

−1

while the ―OH peak of the PVA/PHMG/GO hydrogels shifted by 23 cm

−1

. Therefore

the hydrogen bonding effect of SiO

with PVA/PHMG might be stronger than that of GO. The hydrogen bond interactions among reinforcing agents

PVA and PHMG significantly enhanced the tensile strength of the hydrogel. The tensile strengths of PVA/PHMG/GO and PVA/PHMG/SiO

hydrogels were 1.6 times and 3.3 times of that of PVA/PHMG hydrogels

respectively. This study provides a simple approach to develop reinforced and nonleaching antimicrobial PVA hydrogels.

关键词

聚乙烯醇水凝胶氢键抗菌增强

Keywords

PVA hydrogelHydrogen-bondAntimicrobial performanceEnhancement

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