Progress in Research and Biomedical Applications of Photocrosslinked Hydrogels

Bing-kun Bao; Tuan Liu; Qiu-ning Lin; Lin-yong Zhu

doi:10.11777/j.issn1000-3304.2021.21047

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Progress in Research and Biomedical Applications of Photocrosslinked Hydrogels

Feature Articles | 更新时间：2021-11-03

- Progress in Research and Biomedical Applications of Photocrosslinked Hydrogels
- Acta Polymerica Sinica Vol. 52, Issue 6, Pages: 646-662(2021)
- 作者机构：
  
  上海交通大学生物医学工程学院　上海 200240
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2021.21047
  CLC：
- Published：3 June 2021，
  
  Published Online：7 May 2021，
  
  Received：13 February 2021，
  
  Revised：6 March 2021，
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Bing-kun Bao, Tuan Liu, Qiu-ning Lin, Lin-yong Zhu. Progress in Research and Biomedical Applications of Photocrosslinked Hydrogels. [J]. Acta Polymerica Sinica 52(6):646-662(2021)
DOI：

Bing-kun Bao, Tuan Liu, Qiu-ning Lin, Lin-yong Zhu. Progress in Research and Biomedical Applications of Photocrosslinked Hydrogels. [J]. Acta Polymerica Sinica 52(6):646-662(2021) DOI： 10.11777/j.issn1000-3304.2021.21047.

摘要

光交联制备水凝胶技术具有非物理接触以及时空精确可控等优势，在细胞3D培养/打印以及组织工程和再生医学领域具有广阔的应用前景. 当前，光交联水凝胶的制备主要基于光引发自由基交联反应、光点击交联反应或光偶联交联反应. 本文分别介绍了以上交联反应各自的技术发展史、应用现状以及相关的优势和技术瓶颈. 还着重介绍了本课题组在光交联水凝胶领域开展的研究与转化工作，主要包括提出了利用光笼分子的光剪切释放活性基团触发偶联交联的非自由基光交联策略，即光偶联反应交联策略. 该策略实现了光交联水凝胶的低毒、可控构筑，同时赋予了光交联水凝胶技术的原位组织黏附特性，为该技术的最终临床转化奠定了基础.

Abstract

Photoinduced crosslinking polymerization (PCP) is a novel technology for the preparation of hydrogel. During PCP

the precursors polymerize

in situ

under ambient conditions

and the polymerization rate as well as the conversion of reactive groups can be remotely controlled by changing the position

wavelength

and intensity of the light source. Due to these characters

the hydrogel prepared

via

PCP has shown great potential for biomedical applications

such as 3D cell culture

tissue engineering

regenerative medicine

etc

. The typical PCP types for hydrogel preparation include photoinduced free radical reactions

photoinduced click reactions

and photoinduced coupling reactions. This review explores the strengths and weaknesses of each PCP type and the biomedical applications of the hydrogels prepared

via

PCP. Moreover

this review also discusses the research progress of our group about the preparation of hydrogel

via

the photo activation of photocage to induce coupling reaction named as “photoinduced coupling reaction”. This technology exhibits the advantages of low toxicity and excellent controllability during crosslinking

and the prepared hydrogel shows strong adhesion to tissue

and thus is promising for the practical biomedical applications.

关键词

水凝胶光交联偶联反应组织黏附临床转化

Keywords

HydrogelPhotoinduced crosslinkingCoupling reactionTissue adhesionClinical transformation

references

Drury J L, Mooney D J . Biomaterials , 2003 . 24 ( 24 ): 4337 - 4351 . DOI:10.1016/S0142-9612(03)00340-5http://doi.org/10.1016/S0142-9612(03)00340-5 .

Bai R, Yang J, Suo Z . Eur J Mech A-Solid , 2019 . 74 337 - 370 . DOI:10.1016/j.euromechsol.2018.12.001http://doi.org/10.1016/j.euromechsol.2018.12.001 .

Slaughter B V, Khurshid S S, Fisher O Z, Khademhosseini A, Peppas N A . Adv Mater , 2009 . 21 ( 32-33 ): 3307 - 3329 . DOI:10.1002/adma.200802106http://doi.org/10.1002/adma.200802106 .

Tobin E B, Kristi S A . Chem Soc Rev , 2017 . 46 6532 - 6552 . DOI:10.1039/C7CS00445Ahttp://doi.org/10.1039/C7CS00445A .

Adzima B J, Tao Y, Kloxin C J, DeForest C A, Anseth K S, Bowman C N . Nat Chem , 2011 . 3 256 - 259 . DOI:10.1038/nchem.980http://doi.org/10.1038/nchem.980 .

Rúben F P, Paulo J B . J Appl Polym Sci , 2015 . 132 ( 48 ): 42458 DOI:10.1002/app.42458http://doi.org/10.1002/app.42458 .

Yu C, Schimelman J, Wang P, Miller K L, Ma X, You S, Guan J, Sun B, Zhu W, Chen S . Chem Rev , 2020 . 120 ( 19 ): 10695 - 10743 . DOI:10.1021/acs.chemrev.9b00810http://doi.org/10.1021/acs.chemrev.9b00810 .

van Tomme S R, Storm G, Hennink W E . Int J Pharmaceut , 2008 . 355 ( 1 ): 1 - 18 . DOI:10.1016/j.ijpharm.2008.01.057http://doi.org/10.1016/j.ijpharm.2008.01.057 .

Shi S, Nie J . J Biomed Mater Res B , 2007 . 82B ( 1 ): 44 - 50 . DOI:10.1002/jbm.b.30703http://doi.org/10.1002/jbm.b.30703 .

Weeks A, Morrison D, Alauzun J G, Brook M A, Jones L, Sheardown H . J Biomed Mater Res A , 2012 . 100A ( 8 ): 1972 - 1982 . DOI:10.1002/jbm.a.33269http://doi.org/10.1002/jbm.a.33269 .

Annabi N, Zhang Y N, Assmann A, Sani E S, Cheng G, Lassaletta A D, Vegh A, Dehghani B, Ruiz-Esparza G U, Wang X, Gangadharan S, Weiss A S, Khademhosseini A . Sci Transl Med , 2017 . 9 ( 410 ): eaai7466 DOI:10.1126/scitranslmed.aai7466http://doi.org/10.1126/scitranslmed.aai7466 .

Seidlits S K, Drinnan C T, Petersen R R, Shear J B, Suggs L J, Schmidt C E . Acta Biomater , 2011 . 7 ( 6 ): 2401 - 2409 . DOI:10.1016/j.actbio.2011.03.024http://doi.org/10.1016/j.actbio.2011.03.024 .

Nichol J W, Koshy S T, Bae H, Hwang C M, Yamanlar S, Khademhosseini A . Biomaterials , 2010 . 31 ( 21 ): 5536 - 5544 . DOI:10.1016/j.biomaterials.2010.03.064http://doi.org/10.1016/j.biomaterials.2010.03.064 .

Bae M S, Yang D H, Lee J B, Heo D N, Kwon Y-D, Youn I C, Choi K, Hong J H, Kim G T, Choi Y S, Hwang E H, Kwon I K . Biomaterials , 2011 . 32 ( 32 ): 8161 - 8171 . DOI:10.1016/j.biomaterials.2011.07.045http://doi.org/10.1016/j.biomaterials.2011.07.045 .

Obara K, Ishihara M, Ishizuka T, Fujita M, Ozeki Y, Maehara T, Saito Y, Yura H, Matsui T, Hattori H, Kikuchi M, Kurita A . Biomaterials , 2003 . 24 ( 20 ): 3437 - 3444 . DOI:10.1016/S0142-9612(03)00220-5http://doi.org/10.1016/S0142-9612(03)00220-5 .

Jeon O, Bouhadir K H, Mansour J M, Alsberg E . Biomaterials , 2009 . 30 ( 14 ): 2724 - 2734 . DOI:10.1016/j.biomaterials.2009.01.034http://doi.org/10.1016/j.biomaterials.2009.01.034 .

Kim S H, Chu C C . J Biomed Mater Res , 2000 . 49 ( 4 ): 517 - 527 . DOI:10.1002/(SICI)1097-4636(20000315)49:4<517::AID-JBM10>3.0.CO;2-8http://doi.org/10.1002/(SICI)1097-4636(20000315)49:4<517::AID-JBM10>3.0.CO;2-8 .

Chen Y C, Lin R Z, Qi H, Yang Y, Bae H, Melero-Martin J M, Khademhosseini A . Adv Funct Mater , 2012 . 22 ( 10 ): 2027 - 2039 . DOI:10.1002/adfm.201101662http://doi.org/10.1002/adfm.201101662 .

Lee A, Hudson A R, Shiwarski D J, Tashman J W, Hinton T J, Yerneni S, Bliley J M, Campbell P G, Feinberg A W . Science , 2019 . 365 ( 6452 ): 482 - 487 . DOI:10.1126/science.aav9051http://doi.org/10.1126/science.aav9051 .

Grigoryan B, Paulsen S J, Corbett D C, Sazer D W, Fortin C L, Zaita A J, Greenfield P T, Calafat N J, Gounley J P, Ta A H, Johansson F, Randles A, Rosenkrantz J E, Louis-Rosenberg J D, Galie P A, Stevens K R, Miller J S . Science , 2019 . 364 ( 6439 ): 458 - 464 . DOI:10.1126/science.aav9750http://doi.org/10.1126/science.aav9750 .

Fedorovich N E, Oudshoorn M H, van Geemen D, Hennink W E, Alblas J, Dhert W J A . Biomaterials , 2009 . 30 ( 3 ): 344 - 353 . DOI:10.1016/j.biomaterials.2008.09.037http://doi.org/10.1016/j.biomaterials.2008.09.037 .

Atsumi T, Murata J, Kamiyanagi I, Fujisawa S, Ueha T . Arch Oral Biol , 1998 . 43 ( 1 ): 73 - 81 . DOI:10.1016/S0003-9969(97)00073-3http://doi.org/10.1016/S0003-9969(97)00073-3 .

Intracellular Localization of Photosensitizers[M]. In: Ciba Foundation Symposium 146-Photosensitizing Compounds: Their Chemistry, Biology and Clinical Use, 95−111.

Terakado M, Yamazaki M, Tsujimoto Y, Kawashima T, Nagashima K, Ogawa J, Fujita Y, Sugiya H, Sakai T, Furuyama S . J Dent Res , 1984 . 63 ( 6 ): 901 - 905 . DOI:10.1177/00220345840630061801http://doi.org/10.1177/00220345840630061801 .

Okada H, Suh W K, Jin J, Woo M, Du C, Elia A, Duncan G S, Wakeham A, Itie A, Lowe S W, Wang X, Mak T W . Mol Cell Biol , 2002 . 22 ( 10 ): 3509 - 3517 . DOI:10.1128/MCB.22.10.3509-3517.2002http://doi.org/10.1128/MCB.22.10.3509-3517.2002 .

Williams C G, Malik A N, Kim T K, Manson P N, Elisseeff J H . Biomaterials , 2005 . 26 ( 11 ): 1211 - 1218 . DOI:10.1016/j.biomaterials.2004.04.024http://doi.org/10.1016/j.biomaterials.2004.04.024 .

Mironi-Harpaz I, Wang D Y, Venkatraman S, Seliktar D . Acta Biomater , 2012 . 8 ( 5 ): 1838 - 1848 . DOI:10.1016/j.actbio.2011.12.034http://doi.org/10.1016/j.actbio.2011.12.034 .

Burtscher P . Dent Mater , 1993 . 9 ( 4 ): 218 - 221 . DOI:10.1016/0109-5641(93)90064-Whttp://doi.org/10.1016/0109-5641(93)90064-W .

Bijelic-Donova J, Garoushi S, Lassila L V J, Vallittu P K . Eur J Oral Sci , 2015 . 123 ( 1 ): 53 - 60 . DOI:10.1111/eos.12167http://doi.org/10.1111/eos.12167 .

Rueggeberg F A, Margeson D H . J Dent Res , 1990 . 69 ( 10 ): 1652 - 1658 . DOI:10.1177/00220345900690100501http://doi.org/10.1177/00220345900690100501 .

Lee T Y, Guymon C A, Jönsson E S, Hoyle C E . Polymer , 2004 . 45 ( 18 ): 6155 - 6162 . DOI:10.1016/j.polymer.2004.06.060http://doi.org/10.1016/j.polymer.2004.06.060 .

Gauthier M A, Stangel I, Ellis T H, Zhu X X . J Dent Res , 2005 . 84 ( 8 ): 725 - 729 . DOI:10.1177/154405910508400808http://doi.org/10.1177/154405910508400808 .

Andrzejewska E . Prog Polym Sci , 2001 . 26 ( 4 ): 605 - 665 . DOI:10.1016/S0079-6700(01)00004-1http://doi.org/10.1016/S0079-6700(01)00004-1 .

Guvendiren M, Yang S, Burdick J A . Adv Funct Mater , 2009 . 19 ( 19 ): 3038 - 3045 . DOI:10.1002/adfm.200900622http://doi.org/10.1002/adfm.200900622 .

Krutkramelis K, Xia B, Oakey J . Lab Chip , 2016 . 16 ( 8 ): 1457 - 1465 . DOI:10.1039/C6LC00254Dhttp://doi.org/10.1039/C6LC00254D .

Biswal D, Hilt J . Macromolecules , 2009 . 42 ( 4 ): 973 - 979 . DOI:10.1021/ma801600chttp://doi.org/10.1021/ma801600c .

Mao Y, Anand L . J Mech Phys Solids , 2018 . 115 30 - 53 . DOI:10.1016/j.jmps.2018.02.008http://doi.org/10.1016/j.jmps.2018.02.008 .

Zhong M, Wang R, Kawamoto K, Olsen B D, Johnson J A . Science , 2016 . 353 ( 6305 ): 1264 - 1268 . DOI:10.1126/science.aag0184http://doi.org/10.1126/science.aag0184 .

Yang C, Yin T, Suo Z . J Mech Phys Solids , 2019 . 131 43 - 55 . DOI:10.1016/j.jmps.2019.06.018http://doi.org/10.1016/j.jmps.2019.06.018 .

Sakai T, Matsunaga T, Yamamoto Y, Ito C, Yoshida R, Suzuki S, Sasaki N, Shibayama M, Chung U-i . Macromolecules , 2008 . 41 ( 14 ): 5379 - 5384 . DOI:10.1021/ma800476xhttp://doi.org/10.1021/ma800476x .

Kamata H, Akagi Y, Kayasuga-Kariya Y, Chung U-i, Sakai T . Science , 2014 . 343 ( 6173 ): 873 - 875 . DOI:10.1126/science.1247811http://doi.org/10.1126/science.1247811 .

Kolb H C, Finn M G, Sharpless K B . Angew Chem Int Ed , 2001 . 40 ( 11 ): 2004 - 2021 . DOI:10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5http://doi.org/10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5 .

Gress A, Völkel A, Schlaad H . Macromolecules , 2007 . 40 ( 22 ): 7928 - 7933 . DOI:10.1021/ma071357rhttp://doi.org/10.1021/ma071357r .

McCall J D, Anseth K S . Biomacromolecules , 2012 . 13 ( 8 ): 2410 - 2417 . DOI:10.1021/bm300671shttp://doi.org/10.1021/bm300671s .

DeForest C A, Polizzotti B D, Anseth K S . Nat Mater , 2009 . 8 659 - 664 . DOI:10.1038/nmat2473http://doi.org/10.1038/nmat2473 .

Chen R T, Marchesan S, Evans R A, Styan K E, Such G K, Postma A, McLean K M, Muir B W, Caruso F . Biomacromolecules , 2012 . 13 ( 3 ): 889 - 895 . DOI:10.1021/bm201802whttp://doi.org/10.1021/bm201802w .

Song W, Wang Y, Qu J, Lin Q . J Am Chem Soc , 2008 . 130 ( 30 ): 9654 - 9655 . DOI:10.1021/ja803598ehttp://doi.org/10.1021/ja803598e .

Song W, Wang Y, Qu J, Madden M M, Lin Q . Angew Chem Int Ed , 2008 . 47 ( 15 ): 2832 - 2835 . DOI:10.1002/anie.200705805http://doi.org/10.1002/anie.200705805 .

Fan Y, Deng C, Cheng R, Meng F, Zhong Z . Biomacromolecules , 2013 . 14 ( 8 ): 2814 - 2821 . DOI:10.1021/bm400637shttp://doi.org/10.1021/bm400637s .

Klán P, Šolomek T, Bochet C G, Blanc A, Givens R, Rubina M, Popik V, Kostikov A, Wirz J . Chem Rev , 2013 . 113 ( 1 ): 119 - 191 . DOI:10.1021/cr300177khttp://doi.org/10.1021/cr300177k .

Pelliccioli A P, Wirz J . Photoch Photobio Sci , 2002 . 1 ( 7 ): 441 - 458 . DOI:10.1039/b200777khttp://doi.org/10.1039/b200777k .

Rai P, Mallidi S, Zheng X, Rahmanzadeh R, Mir Y, Elrington S, Khurshid A, Hasan T . Adv Drug Deliver Rev , 2010 . 62 ( 11 ): 1094 - 1124 . DOI:10.1016/j.addr.2010.09.002http://doi.org/10.1016/j.addr.2010.09.002 .

Lin Q, Huang Q, Li C, Bao C, Liu Z, Li F, Zhu L . J Am Chem Soc , 2010 . 132 ( 31 ): 10645 - 10647 . DOI:10.1021/ja103415thttp://doi.org/10.1021/ja103415t .

Lin Q, Bao C, Yang Y, Liang Q, Zhang D, Cheng S, Zhu L . Adv Mater , 2013 . 25 ( 14 ): 1981 - 1986 . DOI:10.1002/adma.201204455http://doi.org/10.1002/adma.201204455 .

DeForest C A, Tirrell D A . Nat Mater , 2015 . 14 ( 5 ): 523 - 531 . DOI:10.1038/nmat4219http://doi.org/10.1038/nmat4219 .

Kloxin A M, Kasko A M, Salinas C N, Anseth K S . Science , 2009 . 324 ( 5923 ): 59 - 63 . DOI:10.1126/science.1169494http://doi.org/10.1126/science.1169494 .

Liu Z, Lin Q, Sun Y, Liu T, Bao C, Li F, Zhu L . Adv Mater , 2014 . 26 ( 23 ): 3912 - 3917 . DOI:10.1002/adma.201306061http://doi.org/10.1002/adma.201306061 .

Yang Y, Li Y, Lin Q, Bao C, Zhu L . ACS Macro Lett , 2016 . 5 ( 3 ): 301 - 305 . DOI:10.1021/acsmacrolett.5b00870http://doi.org/10.1021/acsmacrolett.5b00870 .

Lin Q, Yang L, Wang Z, Hua Y, Zhang D, Bao B, Bao C, Gong X, Zhu L . Angew Chem Int Ed , 2018 . 57 ( 14 ): 3722 - 3726 . DOI:10.1002/anie.201800713http://doi.org/10.1002/anie.201800713 .

Liu Z, Liu T, Lin Q, Bao C, Zhu L . Angew Chem Int Ed , 2015 . 54 ( 1 ): 174 - 178 . DOI:10.1002/anie.201409097http://doi.org/10.1002/anie.201409097 .

Li M, Dove A P, Truong V X . Angew Chem Int Ed , 2020 . 59 ( 6 ): 2284 - 2288 . DOI:10.1002/anie.201912555http://doi.org/10.1002/anie.201912555 .

Lu D, Zhu M, Wu S, Lian Q, Wang W, Adlam D, Hoyland J A, Saunders B R . Adv Funct Mater , 2020 . 30 ( 11 ): 1909359 DOI:10.1002/adfm.201909359http://doi.org/10.1002/adfm.201909359 .

Truong V X, Barner-Kowollik C . ACS Macro Lett , 2021 . 10 ( 1 ): 78 - 83 . DOI:10.1021/acsmacrolett.0c00767http://doi.org/10.1021/acsmacrolett.0c00767 .

Li J, Celiz A D, Yang J, Yang Q, Wamala I, Whyte W, Seo B R, Vasilyev N V, Vlassak J J, Suo Z, Mooney D J . Science , 2017 . 357 ( 6349 ): 378 - 381 . DOI:10.1126/science.aah6362http://doi.org/10.1126/science.aah6362 .

Wang D-A, Varghese S, Sharma B, Strehin I, Fermanian S, Gorham J, Fairbrother D H, Cascio B, Elisseeff J H . Nat Mater , 2007 . 6 ( 5 ): 385 - 392 . DOI:10.1038/nmat1890http://doi.org/10.1038/nmat1890 .

Zhang Y S, Khademhosseini A . Science , 2017 . 356 ( 6337 ): eaaf3627 DOI:10.1126/science.aaf3627http://doi.org/10.1126/science.aaf3627 .

Gristina A . Science , 1987 . 237 ( 4822 ): 1588 - 1595 . DOI:10.1126/science.3629258http://doi.org/10.1126/science.3629258 .

Cui Chunyan(崔春燕), Chen Xinyu(陈薪羽), Liu Bo(刘博), Wu Tengling(武腾玲), Fan Chuanchuan(范川川),Liu Wenguang(刘文广) . Acta Polymerica Sinica(高分子学报) , 2019 . 50 ( 6 ): 613 - 622 . DOI:10.11777/j.issn1000-3304.2019.18270http://doi.org/10.11777/j.issn1000-3304.2019.18270 .

Wang Lian(王黎安), Ge Zhiqing(葛志青), Wang Mozhen(汪谟贞), Ge Xuewu(葛学武) . Acta Polymerica Sinica(高分子学报) , 2020 . 51 ( 12 ): 1335 - 1346 . DOI:10.11777/j.issn1000-3304.2020.20005http://doi.org/10.11777/j.issn1000-3304.2020.20005 .

Moroni L, Elisseeff J H . Mater Today , 2008 . 11 ( 5 ): 44 - 51 . DOI:10.1016/S1369-7021(08)70089-0http://doi.org/10.1016/S1369-7021(08)70089-0 .

Spotnitz W D, Burks S . Transfusion , 2012 . 52 ( 10 ): 2243 - 2255 . DOI:10.1111/j.1537-2995.2012.03707.xhttp://doi.org/10.1111/j.1537-2995.2012.03707.x .

Yuk H, Varela C E, Nabzdyk C S, Mao X, Padera R F, Roche E T, Zhao X . Nature , 2019 . 575 ( 7781 ): 169 - 174 . DOI:10.1038/s41586-019-1710-5http://doi.org/10.1038/s41586-019-1710-5 .

Yang J, Bai R, Suo Z . Adv Mater , 2018 . 30 ( 25 ): 1800671 DOI:10.1002/adma.201800671http://doi.org/10.1002/adma.201800671 .

Ranger W R, Halpin D, Sawhney A S, Lyman M, Locicero J . Am Surgeon , 1997 . 63 ( 9 ): 788 - 795.

Allen M S, Wood D E, Hawkinson R W, Harpole D H, McKenna R J, Walsh G L, Vallieres E, Miller D L, Nichols F C, Smythe W R, Davis R D . Ann Thorac Surg , 2004 . 77 ( 5 ): 1792 - 1801 . DOI:10.1016/j.athoracsur.2003.10.049http://doi.org/10.1016/j.athoracsur.2003.10.049 .

Macchiarini P, Wain J, Almy S, Dartevelle P . J Thorac Cardiov Sur , 1999 . 117 ( 4 ): 751 - 758 . DOI:10.1016/S0022-5223(99)70296-5http://doi.org/10.1016/S0022-5223(99)70296-5 .

Sharma B, Fermanian S, Gibson M, Unterman S, Herzka D A, Cascio B, Coburn J, Hui A Y, Marcus N, Gold G E, Elisseeff J H . Sci Transl Med , 2013 . 5 ( 167 ): 166 - 167 . DOI:10.1126/scitranslmed.3004838http://doi.org/10.1126/scitranslmed.3004838 .

Annabi N, Tsang K, Mithieux S M, Nikkhah M, Ameri A, Khademhosseini A, Weiss A S . Adv Funct Mater , 2013 . 23 ( 39 ): 4950 - 4959 . DOI:10.1002/adfm.201300570http://doi.org/10.1002/adfm.201300570 .

Li L, Smitthipong W, Zeng H . Polym Chem-UK , 2015 . 6 ( 3 ): 353 - 358 . DOI:10.1039/C4PY01415Dhttp://doi.org/10.1039/C4PY01415D .

Lee B P, Messersmith P B, Israelachvili J N, Waite J H . Annu Rev Mater Res , 2011 . 41 ( 1 ): 99 - 132 . DOI:10.1146/annurev-matsci-062910-100429http://doi.org/10.1146/annurev-matsci-062910-100429 .

Jonker A M, Borrmann A, van Eck E R H, van Delft F L, Löwik D W P M, van Hest J C M . Adv Mater , 2015 . 27 ( 7 ): 1235 - 1240 . DOI:10.1002/adma.201404448http://doi.org/10.1002/adma.201404448 .

Liu Y, Meng H, Konst S, Sarmiento R, Rajachar R, Lee B P . ACS Appl Mater Interfaces , 2014 . 6 ( 19 ): 16982 - 16992 . DOI:10.1021/am504566vhttp://doi.org/10.1021/am504566v .

Kim B J, Oh D X, Kim S, Seo J H, Hwang D S, Masic A, Han D K, Cha H J . Biomacromolecules , 2014 . 15 ( 5 ): 1579 - 1585 . DOI:10.1021/bm4017308http://doi.org/10.1021/bm4017308 .

Mehdizadeh M, Weng H, Gyawali D, Tang L, Yang J . Biomaterials , 2012 . 33 ( 32 ): 7972 - 7983 . DOI:10.1016/j.biomaterials.2012.07.055http://doi.org/10.1016/j.biomaterials.2012.07.055 .

Han L, Lu X, Liu K, Wang K, Fang L, Weng L T, Zhang H, Tang Y, Ren F, Zhao C, Sun G, Liang R, Li Z . ACS Nano , 2017 . 11 ( 3 ): 2561 - 2574 . DOI:10.1021/acsnano.6b05318http://doi.org/10.1021/acsnano.6b05318 .

Gan D, Xu T, Xing W, Wang M, Fang J, Wang K, Ge X, Chan C W, Ren F, Tan H, Lu X . J Mater Chem B , 2019 . 7 ( 10 ): 1716 - 1725 . DOI:10.1039/C8TB01664Jhttp://doi.org/10.1039/C8TB01664J .

Yang Y, Zhang J, Liu Z, Lin Q, Liu X, Bao C, Wang Y, Zhu L . Adv Mater , 2016 . 28 2724 - 2730 . DOI:10.1002/adma.201505336http://doi.org/10.1002/adma.201505336 .

Liu X, Yang Y, Niu X, Lin Q, Zhao B, Wang Y, Zhu L . Acta Biomater , 2017 . 62 179 - 187 . DOI:10.1016/j.actbio.2017.05.023http://doi.org/10.1016/j.actbio.2017.05.023 .

Liu X, Yang Y, Li Y, Niu X, Zhao B, Wang Y, Bao C, Xie Z, Lin Q, Zhu L . Nanoscale , 2017 . 9 ( 13 ): 4430 - 4438 . DOI:10.1039/C7NR00352Hhttp://doi.org/10.1039/C7NR00352H .

Ma Y, Yao J, Liu Q, Han T, Zhao J, Ma X, Tong Y, Jin G, Qu K, Li B, Xu F . Adv Funct Mater , 2020 . 30 ( 39 ): 2001820 DOI:10.1002/adfm.202001820http://doi.org/10.1002/adfm.202001820 .

Zhang J, Zhang X, Hong Y, Fu Q, He Q, Mechakra A, Zhu Q, Zhou F, Liang R, Li C, Hu Y, Zou Y, Zhang S, Ouyang H . ACS Appl Mater Interfaces , 2020 . 12 ( 20 ): 22467 - 22478 . DOI:10.1021/acsami.0c01776http://doi.org/10.1021/acsami.0c01776 .

Hong Y, Zhou F, Hua Y, Zhang X, Ni C, Pan D, Zhang Y, Jiang D, Yang L, Lin Q, Zou Y, Yu D, Arnot D E, Zou X, Zhu L, Zhang S, Ouyang H . Nat Commun , 2019 . 10 ( 1 ): 2060 DOI:10.1038/s41467-019-10004-7http://doi.org/10.1038/s41467-019-10004-7 .

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School of Chemistry, Xi'an Jiaotong University

Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin

School of Chemistry, Tiangong University

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