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Controlled Synthesis and Biomedical Applications of Cystine-based Polypeptide Nanomaterials
- ACTA POLYMERICA SINICA Vol. 52, Issue 8, Pages: 960-977(2021)
- 作者机构：
1.中国科学院长春应用化学研究所 中国科学院生态环境高分子材料重点实验室 长春 130022
2.中国科学技术大学应用化学与工程学院 合肥 230026
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2021.21115
CLC：Published：20 August 2021，
Published Online：05 August 2021，
Received：21 April 2021，
Revised：01 June 2021，
扫 描 看 全 文
杨佳臻,邹昊洋,丁建勋等.胱氨酸基聚氨基酸纳米材料的可控合成及其生物医学应用[J].高分子学报,2021,52(08):960-977.
Yang Jia-zhen,Zou Hao-yang,Ding Jian-xun,et al.Controlled Synthesis and Biomedical Applications of Cystine-based Polypeptide Nanomaterials[J].ACTA POLYMERICA SINICA,2021,52(08):960-977.
杨佳臻,邹昊洋,丁建勋等.胱氨酸基聚氨基酸纳米材料的可控合成及其生物医学应用[J].高分子学报,2021,52(08):960-977. DOI： 10.11777/j.issn1000-3304.2021.21115.
Yang Jia-zhen,Zou Hao-yang,Ding Jian-xun,et al.Controlled Synthesis and Biomedical Applications of Cystine-based Polypeptide Nanomaterials[J].ACTA POLYMERICA SINICA,2021,52(08):960-977. DOI： 10.11777/j.issn1000-3304.2021.21115.
摘要
聚氨基酸是一类以氨基酸及其衍生物为结构单元的高分子. 鉴于其多样性的结构单元、优异的生物安全性、便利的修饰性、敏感的生物响应性和独特的二级结构等优异的性能，聚氨基酸在生物医学领域的应用具有显著的优势. 胱氨酸是半胱氨酸通过二硫键连接的二聚体，可以通过环化反应合成为双官能化的胱氨酸
N
-内羧酸酐(Cys
2
NCA)单体. 通过Cys
2
NCA与单官能化的氨基酸
N
-内羧酸酐单体的开环聚合反应，可以可控合成一系列二硫键交联的具有多样性的化学结构、可调的粒径、优异的稳定性和敏感的生物响应性的聚氨基酸纳米材料，从而实现成像剂、生物活性分子等的可控递送. 本文基于本课题组的研究工作综述了单组分、双组分和多组分胱氨酸基聚氨基酸纳米材料的研究进展，并展望了其在临床应用中的机遇与挑战以及新的生物医学应用领域.
Abstract
Polypeptides are a kind of polymers with amino acids and their derivatives as structural units. Given their excellent properties
such as various structural units
excellent biosafety
facile modification
sensitive bioresponsiveness
and unique secondary structures
polypeptides have superior advantages for biomedical applications. Cystine is a dimer of cysteine linked by a disulfide bond
which can be synthesized into a bifunctional cysteine
N
-carboxylanhydride (Cys
2
NCA) monomer by cyclization reaction. Through the ring-opening polymerization of Cys
2
NCA and another monofunctional amino acid NCAs
a series of disulfide-crosslinked polypeptide nanomaterials could be controllably synthesized with diverse chemical structures
adjustable particle sizes
excellent stability
and biological responsiveness to achieve the controlled delivery of imaging agents and bioactive molecules. Based on the recent studies of our group
this review summarized the research progress of single-component
double-component
and multi-component cystine-based polypeptide nanomaterials. To be specific
the functions of single-component cystine-based polypeptide nanomaterials are limited. The double-component polypeptide nanomaterials
which are developed on the basis of single-component ones
show improved drug loading rates
expanded types of loading drugs
and a more stable nanostructures. In order to achieve a more exclusive function as a drug delivery platform
we expect to use the synergy and cascade action of different functionalized amino acids to produce multi-component polypeptide nanomaterials. The multi-component nanoplatform might provide reliable solutions for precision medicine. At last
their opportunities and challenges in clinical application and the new medical application fields were predicted.
关键词
胱氨酸聚氨基酸纳米材料可控合成功能化生物响应性
Keywords
CystinePolypeptideNanomaterialControlled synthesisFunctionalizationBioresponsiveness
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