Polymer Vesicles for Biomedical Applications

Jun-qiu Shi; Shuai Chen; Yun-qing Zhu; Jian-zhong Du

doi:10.11777/j.issn1000-3304.2022.22268

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Polymer Vesicles for Biomedical Applications

Feature Article | 更新时间：2023-11-27

- Polymer Vesicles for Biomedical Applications
- ACTA POLYMERICA SINICA Vol. 54, Issue 3, Pages: 314-326(2023)
- 作者机构：
  
  1.同济大学材料科学与工程学院高分子材料系上海 201804
  2.同济大学附属上海市第四人民医院妇产科上海 200434
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2022.22268
  CLC：
- Published：20 March 2023，
  
  Published Online：26 October 2022，
  
  Received：03 August 2022，
  
  Accepted：08 September 2022
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石隽秋,陈帅,朱云卿等.生物医用高分子囊泡[J].高分子学报,2023,54(03):314-326.

Shi Jun-qiu,Chen Shuai,Zhu Yun-qing,et al.Polymer Vesicles for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(03):314-326.
石隽秋,陈帅,朱云卿等.生物医用高分子囊泡[J].高分子学报,2023,54(03):314-326. DOI： 10.11777/j.issn1000-3304.2022.22268.

Shi Jun-qiu,Chen Shuai,Zhu Yun-qing,et al.Polymer Vesicles for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(03):314-326. DOI： 10.11777/j.issn1000-3304.2022.22268.

摘要

高分子囊泡由于其独特的腔-膜-冠结构，在生物医用等领域具有重要应用前景. 本专论从自组装新机理/新方法和新的生物医学应用两方面总结和评述了近期生物医用高分子囊泡领域的研究进展. 前者包括构建高效包载生物大分子的囊泡的“酸诱导吸附”和“亲和强化吸引”原理、构建完全非对称冠囊泡的“胶束-囊泡转变法”、构建高级囊泡结构的“融合诱导粒子自组装”方法、可宏量制备囊泡的氨基酸环内酸酐开环聚合诱导自组装方法；后者主要介绍“以糖控糖”囊泡、治疗糖尿病溃疡囊泡、抗菌囊泡、抗癌囊泡、靶向治疗骨质疏松症囊泡和护肾血管造影囊泡. 最后，对高分子囊泡的未来发展方向进行了展望.

Abstract

Polymer vesicles have an important application prospect in biomedical and other fields due to their unique lumen-membrane-corona structure. In this feature article

we highlighted recent advance in polymer vesicles for biomedical applications

including new mechanism and methods for self-assembly

and new biomedical applications. The former includes two principles of acid-induced adsorption and affinity-enhanced attraction for preparing vesicles with ultrahigh biomacromolecular loading efficiency

"micelle to vesicle transition" strategy for preparing asymmetric vesicles

fusion-induced particle assembly to build hierarchical vesicles

and ring-opening polymerization of

-carboxyanhydride-induced self-assembly to fabricate vesicles on a large scale; the latter includes vesicles for blood glucose control

vesicles to treat diabetic ulcers

antibacterial vesicles

anticancer vesicles

bone-targeting vesicles to treat osteoporosis and renoprotective angiographic vesicles. Finally

the future development of polymer vesicles and their potential biomedical applications are forecasted.

关键词

高分子囊泡大分子自组装生物医用材料融合诱导自组装

Keywords

Polymer vesiclesMacromolecular self-assemblyBiomedical materialsFusion-induced particle assembly

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Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

School of Applied Chemistry and Engineering, University of Science and Technology of China

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University

The State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University

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