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Engineered Bacteria-based Living Biomaterials for Biomedical Applications
- ACTA POLYMERICA SINICA Vol. 54, Issue 5, Pages: 550-563(2023)
- 作者机构：
武汉大学化学与分子科学学院 生物医用高分子材料教育部重点实验室 武汉 430072
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2022.22334
CLC：Published：20 May 2023，
Published Online：13 December 2022，
Received：08 October 2022，
Accepted：21 November 2022
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陈欢欢,张先正.基于工程化细菌的活性生物材料研究及其医学应用[J].高分子学报,2023,54(05):550-563.
Chen Huan-huan,Zhang Xian-zheng.Engineered Bacteria-based Living Biomaterials for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(05):550-563.
陈欢欢,张先正.基于工程化细菌的活性生物材料研究及其医学应用[J].高分子学报,2023,54(05):550-563. DOI： 10.11777/j.issn1000-3304.2022.22334.
Chen Huan-huan,Zhang Xian-zheng.Engineered Bacteria-based Living Biomaterials for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(05):550-563. DOI： 10.11777/j.issn1000-3304.2022.22334.
摘要
细菌由于具有高度生物相容性、运动性和可自主感应生理信号，基于细菌的疗法和递送系统已经被广泛应用于医学领域，包括生物成像、疾病治疗以及组织修复与再生等. 本文从工程化细菌的构建、生物医学应用以及临床转化三方面总结和评述了生物医用工程化细菌领域的研究进展. 重点介绍了通过化学工程化策略对细菌进行改造，在维持细菌自主性和动态功能的同时赋予其新的功能，提高疾病诊断效率，改善治疗效果. 此外，还探讨了工程化的细菌在医学领域上的最新进展和应用前景，最后对工程化细菌未来在医学应用上的挑战进行了简要的展望.
Abstract
Living bacteria have the characteristics of biocompatibility
motility and can autonomously sense physiological signals
which can be used as therapeutic agents or drug carriers for the treatment of a variety of intractable diseases
including bioimaging
disease treatment
and tissue repair and regeneration. However
bacteria still have shortcomings for medical applications. For examples
some bacteria are often fragile to unfriendly environmental stimulation
leading to unnecessary bacterial death and reduced treatment effectiveness. Recently
various physicochemical and bioengineered modification strategies have been developed for individual bacteria to improve the bioavailability and efficacy
as well as achieve targeted delivery of conventional drugs. In this review
we highlight recent advance in engineered bacteria-based living biomaterials for biomedical applications in terms of engineered bacteria
biomedical application
and clinical transformation. According to the charge state
chemical groups
proteins and antigens of the bacterial surface
we systematically introduce the engineered bacteria modified with physicochemical and bioengineered strategies
especially for single bacteria. In addition
we highlight engineered bacteria-based living biomaterials for emerging diagnosis and advanced therapy
including imaging
biosensor
disease treatment
and tissue repair and regeneration
etc. Furtherly
in the clinical translation
we summarize the new progress of engineered bacteria in the treatment of tumor and gastrointestinal diseases
as well as the great success of engineered bacteria in various clinical trials. Finally
the opportunities and challenges in the future medical application of engineered bacteria have been briefly prospected. This review offers the progress in the application of engineered bacteria based on living biomaterials in biomedical application
which has potential for the development of bacterial therapy in the future.
关键词
活性生物材料工程化细菌化学修饰基因编辑医学应用
Keywords
Living biomaterialBiomedical applicationEngineered bacteriaChemical modificationGene editing
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