Study on Antibacterial Function of Polyurethane Surface Modified with Endothelializable <italic style="font-style: italic">β</italic>-Peptide Polymer

Rui-yi Zhou; Yun-rui She; Yue-ming Wu; Jun-yu Zhang; Jing Wang; Run-hui Liu

doi:10.11777/j.issn1000-3304.2022.22406

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Study on Antibacterial Function of Polyurethane Surface Modified with Endothelializable β-Peptide Polymer

Research Article | 更新时间：2023-06-21

- Study on Antibacterial Function of Polyurethane Surface Modified with Endothelializable β-Peptide Polymer
- ACTA POLYMERICA SINICA Vol. 54, Issue 7, Pages: 1055-1063(2023)
- 作者机构：
  
  1.华东理工大学材料科学与工程学院教育部医用生物材料工程研究中心上海 200237
  2.华东理工大学深圳研究院深圳 518063
- 作者简介：
  
  Run-hui Liu, E-mail: rliu@ecust.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2022.22406
  CLC：
- Published：20 July 2023，
  
  Published Online：22 March 2023，
  
  Received：25 November 2022，
  
  Accepted：20 January 2023
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周睿毅,佘蕴芮,武月铭等.促内皮化β-多肽聚合物修饰的聚氨酯表面抗菌功能研究[J].高分子学报,2023,54(07):1055-1063.

Zhou Rui-yi,She Yun-rui,Wu Yue-ming,et al.Study on Antibacterial Function of Polyurethane Surface Modified with Endothelializable β-Peptide Polymer[J].ACTA POLYMERICA SINICA,2023,54(07):1055-1063.
周睿毅,佘蕴芮,武月铭等.促内皮化β-多肽聚合物修饰的聚氨酯表面抗菌功能研究[J].高分子学报,2023,54(07):1055-1063. DOI： 10.11777/j.issn1000-3304.2022.22406.

Zhou Rui-yi,She Yun-rui,Wu Yue-ming,et al.Study on Antibacterial Function of Polyurethane Surface Modified with Endothelializable β-Peptide Polymer[J].ACTA POLYMERICA SINICA,2023,54(07):1055-1063. DOI： 10.11777/j.issn1000-3304.2022.22406.

摘要

由于血管移植物在植入过程中容易引起内皮损伤及微生物感染的风险，迫切需要研究能够促进表面内皮化并抗微生物感染的生物材料来降低这些风险发生的概率. 本工作将近期发现的具有促内皮化功能的

-多肽聚合物修饰到人工血管常用材料热塑型聚氨酯(TPU)表面，并研究其抗菌功能. 研究表明，

-多肽聚合物修饰表面对耐药革兰氏阳性菌和阴性菌表现出广谱的高效抗菌活性. 此外，该功能化TPU表面仍具有优异的选择性促内皮细胞黏附的能力，可满足人工血管移植物抗感染及促内皮化的多功能需求.

Abstract

Vascular grafts are prone to cause risks of endothelial damage and microbial infection during implantation

so there is an urgent need to find multifunctional biomaterials with endothelializable and antibacterial functions to reduce these risks. Host defense peptides (HDPs) have broad-spectrum antimicrobial activity and are widely used to inhibit microbial infections. However

the application of these peptides is limited due to their low stability

expensive and time-consuming synthesis. Therefore

in order to meet the multifunctional requirements of vascular grafts and address these limitations

endothelializable

-peptide polymer NM

was used as HDPs mimics for antibacterial functional studies in this work.

-Peptide polymer NM

was grafted to the surface of thermoplastic polyurethane (TPU)

commonly used in artificial vascular grafts

via

a process of O

plasma activation followed by brominated modification. The effective functionalization of TPU surface was confirmed by ellipsometry

X-ray photoelectron spectroscopy and water contact angle characterization. Antibacterial studies showed that NM

-modified TPU surface exhibited broad-spectrum antibacterial activity against multi-drug resistant Gram-positive and Gram-negative bacteria

as well as efficient contact-killing ability. Antimicrobial mechanism study indicated that NM

-modified TPU surface killed bacteria by interacting with bacterial membrane. Meanwhile

the functionalized TPU surface displayed excellent blood compatibility. In addition

-peptide polymer NM

-modified TPU surface maintained superior endothelial-selective cell adhesion

which can effectively reduce the risk of microbial infection and endothelial damage of vascular grafts

implying great potential in the treatment of cardiovascular disease.

关键词

β-多肽聚合物宿主防御肽抗菌内皮化

Keywords

β-Peptide polymerHost defense peptideAntibacterialEndothelialization

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Related Institution

Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University

Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine

College of Applied Chemistry and Engineering, University of Science and Technology of China

National Engineering Laboratory of Medical Implant Devices

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Study on Antibacterial Function of Polyurethane Surface Modified with Endothelializable β-Peptide Polymer

DOI：10.11777/j.issn1000-3304.2022.22406

摘要

Abstract

关键词

Keywords

references