Nanomaterials Self-assembled from Peptide/Poly(amino acid) for Cancer Theranostics

Run-xin Teng; Zhen Fan; Jian-zhong Du

doi:10.11777/j.issn1000-3304.2023.23047

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Nanomaterials Self-assembled from Peptide/Poly(amino acid) for Cancer Theranostics

Feature Article | 更新时间：2023-05-31

- Nanomaterials Self-assembled from Peptide/Poly(amino acid) for Cancer Theranostics
- ACTA POLYMERICA SINICA Vol. 54, Issue 6, Pages: 853-869(2023)
- 作者机构：
  
  同济大学材料科学与工程学院高分子材料系上海 201804
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2023.23047
  CLC：
- Published：20 June 2023，
  
  Published Online：25 April 2023，
  
  Received：04 March 2023，
  
  Accepted：03 April 2023
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滕润鑫,范震,杜建忠.肿瘤诊疗多肽/聚氨基酸自组装纳米材料[J].高分子学报,2023,54(06):853-869.

Teng Run-xin,Fan Zhen,Du Jian-zhong.Nanomaterials Self-assembled from Peptide/Poly(amino acid) for Cancer Theranostics[J].ACTA POLYMERICA SINICA,2023,54(06):853-869.
滕润鑫,范震,杜建忠.肿瘤诊疗多肽/聚氨基酸自组装纳米材料[J].高分子学报,2023,54(06):853-869. DOI： 10.11777/j.issn1000-3304.2023.23047.

Teng Run-xin,Fan Zhen,Du Jian-zhong.Nanomaterials Self-assembled from Peptide/Poly(amino acid) for Cancer Theranostics[J].ACTA POLYMERICA SINICA,2023,54(06):853-869. DOI： 10.11777/j.issn1000-3304.2023.23047.

摘要

多肽/聚氨基酸分子由于优异的生物相容性、序列可控性和高生物活性等特点，已经被广泛应用于肿瘤诊疗等生物医学领域. 然而，这些分子仍然存在一定的缺陷，如光学性质不佳、半衰期短与清除速率快等. 本文简述了通过对多肽/聚氨基酸分子的序列设计、侧链修饰和自组装条件进行调控，赋予其可控的光学性质以用于生物成像，更优异的药代动力学和药效学以获得更好的治疗效果. 重点介绍了该领域以及本课题组近期关于多肽/聚氨基酸自组装纳米材料的构筑理念及其在肿瘤诊疗领域的应用研究，并对该领域的挑战和未来发展前景进行了展望.

Abstract

Owing to the excellent biocompatibility

chemical diversity and sequence dependent bioactivity

peptides/poly(amino acids) have been widely used in biomedical applications

especially in tumor theranostics. However

there are still certain drawback of peptide/poly(amino acid) to overcome for future clinical applications

such as limited optical properties

short half-life and fast clearance rate. In this feature article

we describe the sequence design

side chain modification and self-assembled spatial structure of peptide/poly(amino acid). Such factors endow them with additional optical properties and enhanced pharmacokinetic

pharmacodynamic and immunological properties. We focus on the applications of biomaterials self-assembled from peptides/poly(amino acids) in the aspect of tumor diagnosis and treatment. Additionally

we propose important challenges and future prospects of peptide/poly(amino acid)-based biomaterials for tumor diagnosis and treatment.

关键词

多肽聚氨基酸自组装肿瘤诊疗

Keywords

PeptidePoly(amino acid)Self-assemblyTumor theranostics

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