A CELL MEMBRANE BIOMIMETIC POLYMER FOR SURFACE MODIFICATION OF CARBON NANOTUBES

XU Fangming; XU Jianping; JI Jian; SHEN Jiacong

doi:10.3724/SP.J.1105.2008.01006

您当前的位置：

首页 >

文章列表页 >

A CELL MEMBRANE BIOMIMETIC POLYMER FOR SURFACE MODIFICATION OF CARBON NANOTUBES

Research Bulletin | 更新时间：2021-03-19

- A CELL MEMBRANE BIOMIMETIC POLYMER FOR SURFACE MODIFICATION OF CARBON NANOTUBES
- Acta Polymerica Sinica Issue 10, Pages: 1006-1009(2008)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.3724/SP.J.1105.2008.01006
  CLC：
- Published：20 October 2008，
扫描看全文
XU Fangming, XU Jianping, JI Jian, SHEN Jiacong. A CELL MEMBRANE BIOMIMETIC POLYMER FOR SURFACE MODIFICATION OF CARBON NANOTUBES. [J]. Acta Polymerica Sinica (10):1006-1009(2008)
DOI：

XU Fangming, XU Jianping, JI Jian, SHEN Jiacong. A CELL MEMBRANE BIOMIMETIC POLYMER FOR SURFACE MODIFICATION OF CARBON NANOTUBES. [J]. Acta Polymerica Sinica (10):1006-1009(2008) DOI： 10.3724/SP.J.1105.2008.01006.

摘要

以新型含有磷酸胆碱基的仿细胞膜两亲聚合物——胆固醇封端的聚(2-甲基丙烯酰氧基乙基磷酸胆碱)(CPMPC)为表面稳定剂实现碳纳米管的表面改性，利用两亲聚合物中的胆固醇疏水段与碳纳米管表面进行非共价键的稳定结合，通过两亲聚合物中聚(2-甲基丙烯酰氧基乙基磷酰胆碱)(PMPC)亲水段实现其水溶性和生物相容性.并以商业可获得的典型两亲分子，末端为胆固醇的聚氧乙烯(CPEG)和卵磷脂，为对照进行研究.研究表明CPMPC和CPEG均具有比卵磷脂更高的对碳纳米管进行分散的能力.而CPMPC改性的碳纳米管比CPEG改性的碳纳米管具有更优的稳定性和生物相容性，通过新型仿细胞膜聚合物改性的碳纳米管在生物医用领域有潜在应用.

Abstract

A novel biomimetic amphiphilic polymer

cholesterol-end-capped-poly(2-methacryloyloxyethyl phosphorylcholine) (CPMPC)

was used as surfactant to achieve water soluble and biocompatible carbon nanotubes (CNTs).Crude CNTs were facilely dispersed in aqueous media by ultrasonication with the help of CPMPC

with cholesterol-end-capped PEG (CPEG) and lecithin as controls.The ability of the novel biomimetic amphiphile to solubilize and stabilize the CNTs was investigated by UV spectra.The solubility of CNTs in 1 mg/mL CPMPC and CPEG aqueous solutions was found to be 1.705 mg/mL and 1.468 mg/mL

respectively.The solubility of CNTs

in 0.8 mg/mL lecithin was

however

only 0.326 mg/mL.Furthermore

CPMPC coated CNTs precipitated quite slowly compared with CPEG coated CNTs

which indicated better stabilizing ability of CPMPC.Cell culture was used to evaluate the biocompatibility of the amphiphiles stabilized CNTs using MTT assay and cell morphology observation.While CPEG coated CNTs showed obviously detrimental effect on the growth of HUVEC304 cells

CPMPC coated CNTs did not exhibit obvious toxicity.The biocompatible CPMPC coated CNTs represent an excellent nano-object for potential biomedical applications.

关键词

碳纳米管磷酸胆碱细胞膜仿生生物相容性

Keywords

references

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

SURFACE ENGINEERING OF POLY(AMIDO-AMINE) via BIOMIMETIC PHOSPHORYLCHOLINE

SELECTIVE LOCALIZATION OF CARBON NANOTUBES IN IMMISCIBLE BLENDS OF POLY(TRIMETHYLENE TEREPHTHALATE) AND ETHYLENE-VINYL ACETATE COPOLYMERS

POLYMER-ASSISTED ALIGNMENT AND ASSEMBLY OF CARBON NANOTUBES

SYNTHESIS AND ELECTROCHEMICAL PROPERTIES OF CARBON NANOTUBEPOLY [3′,4′-ETHYLENEDIOXY-2,2′:5′,2″-TERTHIOPHENE] NANOCOPOSITES

SYNTHESIS OF GLYCOSYLATED THERMORESPONSIVE HYDROGELS AND THEIR INTERACTIONS WITH HepG2 CELLS

Related Author

No data

Related Institution

扬州大学化学化工学院

扬州大学测试中心

Postal code：100190
Tel：010-62588927 Email：gfzxb@iccas.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05002797号-8 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰