SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC MULTIBLOCK COPOLYMERS BASED ON POLY(p-DIOXANONE) AND POLY(ETHYLENE GLYCOL)

MOU Yurong; SHI Jing; CHEN Sichong; WANG Yuzhong

doi:10.3724/SP.J.1105.2009.00203

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SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC MULTIBLOCK COPOLYMERS BASED ON POLY(p-DIOXANONE) AND POLY(ETHYLENE GLYCOL)

Research Article | 更新时间：2021-03-19

- SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC MULTIBLOCK COPOLYMERS BASED ON POLY(p-DIOXANONE) AND POLY(ETHYLENE GLYCOL)
- Acta Polymerica Sinica Issue 3, Pages: 203-208(2009)
- 作者机构：
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- DOI：10.3724/SP.J.1105.2009.00203
  CLC：
- Published：20 March 2009，
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MOU Yurong, SHI Jing, CHEN Sichong, WANG Yuzhong. SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC MULTIBLOCK COPOLYMERS BASED ON POLY(p-DIOXANONE) AND POLY(ETHYLENE GLYCOL). [J]. Acta Polymerica Sinica (3):203-208(2009)
DOI：

MOU Yurong, SHI Jing, CHEN Sichong, WANG Yuzhong. SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC MULTIBLOCK COPOLYMERS BASED ON POLY(p-DIOXANONE) AND POLY(ETHYLENE GLYCOL). [J]. Acta Polymerica Sinica (3):203-208(2009) DOI： 10.3724/SP.J.1105.2009.00203.

摘要

首先合成双端羟基的聚对二氧环己酮预聚物(PPDO)和双端羧基的聚乙二醇预聚物（PEG），然后以丁二酸酐/二环己基碳二亚胺（DCC）将PPDO与PEG偶联共聚，得到PPDO/PEG多嵌段共聚物.通过1H-NMR和GPC表征了聚合物的结构和分子量.采用差示扫描量热法（DSC）和热重分析（TGA）研究了共聚物的结晶性能和热稳定性.用透析法制备了共聚物纳米粒子，并用动态光散射（DLS）表征了共聚物纳米粒子的粒径及分散度，结果表明，随着共聚物亲水链段PEG含量的增加，其纳米粒子更易形成，粒子粒径随共聚物分子量增大而增大.

Abstract

In order to overcome the defects of poly(p-dioxanone)(PPDO) due to its hydrophobicity

amphiphilic PPDO/poly(ethylene glycol)(PEG) multiblock copolymers were synthesized by coupling the dihydroxylterminated PPDO with dicarboxylic acidterminated PEG.The structures and molecular characteristics of the resulting PPDO/PEG multiblock copolymers were studied by 1H-NMR and GPC.The crystallization and thermal stability of the copolymers were studied using DSC and TGA.DSC analysis showed that the PPDO blocks restrained the crystallization of PEG blocks.TGA showed that the multiblock copolymers underwent thermal degradation in two separate steps for the PPDO and PEG blocks

respectively from which the PPDO contents could be calculated

and the results were very close to the theoretical values.Polymeric nanoparticles were prepared in an aqueous medium by dialysis technique.The more the content of hydrophilic PEG in copolymers

the easier the formation of nanoparticles.Dynamic light scattering (DLS) was used to investigate the nanoparticles of copolymers

showing a mono-dispersed size distribution and hydrodynamic diameters of around 173～193 nm .The novel PPDO/PEG multiblock copolymers may have a potential application in drug delivery systems.

关键词

聚对二氧环己酮聚乙二醇嵌段共聚物两亲性纳米粒子

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Guangzhou Institute of Chemistry, Chinese Academy of Sciences

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