Aminolysis was used to improve the hydrophilicity of poly(γ-benzyl-L-glutamate)

PBLG.Hydrophobic benzyl side chain groups in PBLG were changed to hydrophilic hydroxyalkyl groups by aminolysis reaction.Poly(L-alanine-co-5

N-hydroxypropyl-L-glutamine)

(P(A-co-HPG)) and poly(L-alanine)-b-poly(5

N-hydroxypropyl-L-glutamine)

(PA-b-PHPG) were synthesized in this paper

both initiated by n-propylamine.The structure and basic properties were characterized by IR and 1H-NMR.Both PA-b-PHPG and P(A-co-HPG) have the amphiphilic properties

where PA is the hydrophobic part and PHPG is the hydrophilic part.Compared with the block copolymer

the synthesis of random copolymer P(A-co-HPG) was more simple and of high efficiency.At the same time

the micellization processes of PA10-b-PHPG40 and P(A10-co-HPG40) were monitored by 1H-NMR.TEM results showed that both PA10-b-PHPG40 and P(A10-co-HPG40) could selfassembled into evenly micelles in water.However

the size of the micelles made of random copolymers was smaller than that of block copolymers

and the shape of random copolymer micelles were not regular spheres as micelles made of block copolymer.At the same time

it was found that the ratio between hydrophiphilic and hydrophobic monomers played a very important role in micelle formation.The most uniform micelle size distribution was observed in P(A10-co-HPG40) micellar solutions.