A novel targeted carrier of drug loaded microcapsules with thermo- and magnetic-sensitivities was fabricated by the layer-by-layer self-assembly technique.Natural polyelectrolytes such as chitosan and sodium alginate

magnetic nanoparticles Fe3O4

and lipid dipalmitoyl-sn-glycero-3-phosphate (monosodium salt) (DPPA)

(1

2-dipalmitoyl-sn-glycero-3-phosphocholine) (DPPC) or their composite 10%DPPA/90%DPPC were used as components of microcapsule.The structure

drug loading and thermo-sensitive drug release of the microcapsules were characterized by TEM

SEM

laser scanning confocal microscope and ultraviolet spectrophotometer.The results showed that positive Fe3O4 nanoparticles with superparamagnetic property were successfully assembled on the microcapsules

which could be effectively trapped by solid permanent magnet.The drug entrapment efficiency is affected by the drug concentration and the temperature.The highest drug loading amount could reach to 22.40% when the temperature reached 60℃.The drug release properties of microcapsules were measured at 37℃ and 40℃

which were lower and higher than the phase transition of DPPA lipid film respectively.The results showed that the microcapsules with lipid film were sensitive to temperature.The thermo-sensitive lipid film assembled on the surface of microcapsule could effectively prevent drug from being released at the lower temperature

which will favor the drug to reach the targeted site with less drug loss.