SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC TRIBLOCK COPOLYMERS PEG\|POLY(Nε-CBZ-LYSINE)-POLY(LACTIC ACID)

XIANG Li; LONG Feng; YANG Ke; FAN Junbing; XIANG Jiannan; ZHU Mingqiang

doi:10.3724/SP.J.1105.2010.09395

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SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC TRIBLOCK COPOLYMERS PEG\|POLY(Nε-CBZ-LYSINE)-POLY(LACTIC ACID)

Research Bulletin | 更新时间：2021-03-19

- SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC TRIBLOCK COPOLYMERS PEG\|POLY(Nε-CBZ-LYSINE)-POLY(LACTIC ACID)
- Acta Polymerica Sinica Issue 6, Pages: 788-792(2010)
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- DOI：10.3724/SP.J.1105.2010.09395
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- Published：20 June 2010，
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XIANG Li, LONG Feng, YANG Ke, FAN Junbing, XIANG Jiannan, ZHU Mingqiang. SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC TRIBLOCK COPOLYMERS PEG\|POLY(Nε-CBZ-LYSINE)-POLY(LACTIC ACID). [J]. Acta Polymerica Sinica (6):788-792(2010)
DOI：

XIANG Li, LONG Feng, YANG Ke, FAN Junbing, XIANG Jiannan, ZHU Mingqiang. SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC TRIBLOCK COPOLYMERS PEG\|POLY(Nε-CBZ-LYSINE)-POLY(LACTIC ACID). [J]. Acta Polymerica Sinica (6):788-792(2010) DOI： 10.3724/SP.J.1105.2010.09395.

摘要

用端氨基聚乳酸做引发剂，在DMF中引发Nε-苄氧羰基-L-赖氨酸酐（Lys(Z)-NCA）聚合，合成了端氨基聚(Nε-苄氧羰基-L-赖氨酸)-b-聚乳酸两嵌段共聚物.以端羧基聚乙二醇经NHS活化与端氨基聚(Nε-苄氧羰基-L-赖氨酸)-b-聚乳酸偶联，合成了聚(乳酸-b-Nε-苄氧羰基-L-赖氨酸-b-乙二醇)三嵌段聚合物.利用IR、1H\|NMR、GPC和TEM对它们的结构、形态进行了表征，结果表明，所合成的分子量可控、分子量分布窄(Mw/Mn =1.07)的嵌段共聚物，酰化反应产率达70%以上.同时聚乙二醇和Nε-苄氧羰基-L-赖氨酸被引入到聚乳酸主链中，在聚合物侧链脱保护后有望改善聚乳酸的细胞亲和性.

Abstract

A poly(lactic acid)\|based block copolymer was synthesized in order to increase the cell ahesion of poly(lactic acid).Lys(Z)NCA was first synthesized from Nε-carbobenzyloxy-L-lysine and triphosgene in THF.Diblock copolymers aminoended poly(Nε-carbobonzyloxy-L-lysine)-b-poly(lactic acid) were synthesized in DMF in the condition that amino-ended PLA was used as initiator.Amphiphilic triblock copolymers poly(L-lactic acid)-b-poly(Nεcarbobonzyloxy-L-lysine)-b-poly(ethylene glycol) were synthesized in CHCl3 in the condition that amino-ended poly(lactic acid)-b-poly(Nε-carbobenzyloxy-L-lysine) was acylationed by carboxyl-terminal poly(ethylene glyco1).The block copolymers were characterized via IR(infrared spectroscopy)

1H-NMR(nuclear magnetic resonance)

GPC(gel permeation chromatography) and TEM(transmission electron micrographs).The results revealed that triblock copolymers with controlled Mn and narrow molecular weight distribution (Mw/Mn =1.07) were synthesized

the acylation reaction yield was more than 70%.Poly(ethylene glyco1) and Nε-carbobenzyloxy-L-lysine were introduced into the main chain of poly(lactic acid)

and a kind of ideal bioabsorbable polymer materials were obtained.

关键词

聚乳酸-b-聚(Nε-苄氧羰基-L-赖氨酸)-b-聚乙二醇三嵌段聚合物聚乙二醇聚乳酸聚Nε苄氧羰基-L-赖氨酸Nε-苄氧羰基-L-赖氨酸酸酐(Lys(Z)-NCA)

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Key laboratory of Auxiliary Chemistry and Technology for Chemical Industry of Ministry of Education, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology

扬州大学化学化工学院

扬州大学江苏省环境工程与环境材料重点实验室

扬州大学测试中心

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