Organic Soluble Superparamagnetic Iron Oxide Nanoparticles Coated with PSI-g-PEG-DDA and MRI Imaging for Cancer Diagnosis

Hai-long Huang; Shu-bo Zhai; Cai-jin Li; Ying-mu Zhang; Jing-yuan Wang; Liang Chen

doi:10.3724/SP.J.1105.2014.13186

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Organic Soluble Superparamagnetic Iron Oxide Nanoparticles Coated with PSI-g-PEG-DDA and MRI Imaging for Cancer Diagnosis

Research Article | 更新时间：2021-03-19

- Organic Soluble Superparamagnetic Iron Oxide Nanoparticles Coated with PSI-g-PEG-DDA and MRI Imaging for Cancer Diagnosis
- Acta Polymerica Sinica Issue 2, Pages: 194-201(2014)
- 作者机构：
  
  1. 吉林大学化学化学学院麦克德尔米德实验室,长春,130012
  2. 吉林大学第一医院,长春,130021
- 作者简介：
- 基金信息：
- DOI：10.3724/SP.J.1105.2014.13186
  CLC：
- Published：20 February 2014，
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Hai-long Huang, Shu-bo Zhai, Cai-jin Li, Ying-mu Zhang, Jing-yuan Wang, Liang Chen. Organic Soluble Superparamagnetic Iron Oxide Nanoparticles Coated with PSI-g-PEG-DDA and MRI Imaging for Cancer Diagnosis. [J]. Acta Polymerica Sinica (2):194-201(2014)
DOI：

Hai-long Huang, Shu-bo Zhai, Cai-jin Li, Ying-mu Zhang, Jing-yuan Wang, Liang Chen. Organic Soluble Superparamagnetic Iron Oxide Nanoparticles Coated with PSI-g-PEG-DDA and MRI Imaging for Cancer Diagnosis. [J]. Acta Polymerica Sinica (2):194-201(2014) DOI： 10.3724/SP.J.1105.2014.13186.

摘要

天冬氨酸（ASP）自身热缩聚产物聚琥珀酰亚胺（PSI）通过与氨基化聚乙二醇单甲醚（-胺基--甲氧基-聚乙二醇）和十二胺（DDA）进行连续两步开环反应，制备了双亲性蜈蚣形聚合物聚琥珀酰亚胺接枝聚乙二醇与十二胺（PSI-g-PEG-DDA）.随着改变疏水链段DDA的接枝比例，通过胶束粒径的变化确定了最佳的接枝比例.核磁共振波谱（1H-NMR）及凝胶渗透色谱（GPC）对聚合物的性质进行了表征.通过相转移法，聚合物对油溶性超顺磁性氧化铁纳米粒子进行包覆，制备了新型的水溶性超顺磁性氧化铁纳米粒子（PSI-g-PEG-DDA@IONPs）.动态光散射（DLS）和透射电镜（TEM）对新型的水溶性氧化铁纳米粒子的粒径与形貌进行了表征.体外T2核磁造影成像（MRI in vitro）确定了制备的氧化铁纳米粒子的R2质子驰豫率.肝癌小鼠模型的体内核磁造影成像（MRI in vivo）结果表明新型氧化铁纳米粒子对肿瘤部位有明显的T2核磁造影增强效应，并有很长的体内循环半衰期.以上实验结果表明，新型的水溶性纳米氧化铁粒子可以作为一种潜在的用于肿瘤检测的核磁造影剂.

Abstract

This research aimed to develop a novel polymeric micelle system to deliver iron oxide nanoparticles to tumor regions. To achieve the purpose above

the amphiphilic rentipede-like polymer poly(succinimide)-grafted-poly(ethylene glycol)-dodecylamine (PSI-g-PEG-DDA) was successfully synthesized. A study on structure and properties was conducted then through gel permeation chromatography (GPC) and nuclear magnetic resonance (1H-NMR). Through the phase transfer process

the amphiphilic polymer was used to encapsulate the superparamagnetic iron oxides (SPIOs) for preparing the stable water-soluble SPIOs. The product was found to form spherical micelles in aqueous media due to its amphiphilic nature with an average particle size of 50 nm measured by dynamic light scattering (DLS) and TEM imaging. Magnetization curve showed the water-soluble IONPs kept the superparamagnetic property of organic IONPs. An MTT assay showed no significant cytotoxicity of IONPs to HepG2 cells. Remarkably

MRI showed that IONPs displayed a clear concentration-dependent T2 signal reduction effect

with an R2 value of 187.3 (mmol/L)-1 s-1. The result of mice magnetic response imaging (MRI) in vivo showed that this new type of SPIOs caused a great enhancement effect on T2 magnetic resonance and long half-life in the circulation

which confirmed that it could be used as a potential contrast agent.

关键词

两亲性蜈蚣形聚合物胶束超顺磁性氧化铁核磁造影成像

Keywords

Amphiphilic centipede-polymerMicelleSuperparamagnetic iron oxidesMagnetic response imaging

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College of Chemistry, State Key Laboratory of Supramolecular Structure and Materials, Jilin University

陕西科技大学教育部轻化工助剂化学与技术重点实验室

Department of Polymer Science and Engneering, Zhejiang University

MOE Key Laboratory of Macromolecular Synthesis and Functionalization

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