丙烯酸β-羧乙酯-苯乙烯共聚物缩合异烟肼的合成及其水解释放研究

陈星; 胡力平; 焦书科

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丙烯酸β-羧乙酯-苯乙烯共聚物缩合异烟肼的合成及其水解释放研究

研究简报 | 更新时间：2021-03-19

- 丙烯酸β-羧乙酯-苯乙烯共聚物缩合异烟肼的合成及其水解释放研究
- THE STUDIES ON SYNTHESIS OF CONDENSATION PRODUCT OF ACRYLOXYPROPIONIC ACID-STYRENE COPOLYMER AND ISONIAZIDUM AND ITS BEHAVIOR DURING THE PROCESS OF HYDROLYSIS
- 高分子学报 1988年第5期页码：385-388
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- 纸质出版日期：1988-10-20，
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陈星, 胡力平, 焦书科. 丙烯酸β-羧乙酯-苯乙烯共聚物缩合异烟肼的合成及其水解释放研究[J]. 高分子学报, 1988,(5):385-388.

CHEN Xing, HU Li-ping, JIAO Shu-ke. THE STUDIES ON SYNTHESIS OF CONDENSATION PRODUCT OF ACRYLOXYPROPIONIC ACID-STYRENE COPOLYMER AND ISONIAZIDUM AND ITS BEHAVIOR DURING THE PROCESS OF HYDROLYSIS[J]. Acta Polymerica Sinica, 1988,(5):385-388.
陈星, 胡力平, 焦书科. 丙烯酸β-羧乙酯-苯乙烯共聚物缩合异烟肼的合成及其水解释放研究[J]. 高分子学报, 1988,(5):385-388. DOI：

CHEN Xing, HU Li-ping, JIAO Shu-ke. THE STUDIES ON SYNTHESIS OF CONDENSATION PRODUCT OF ACRYLOXYPROPIONIC ACID-STYRENE COPOLYMER AND ISONIAZIDUM AND ITS BEHAVIOR DURING THE PROCESS OF HYDROLYSIS[J]. Acta Polymerica Sinica, 1988,(5):385-388. DOI：

摘要

Abstract

The synthesis of macromolecular-drug and its behavior during the process of hydrolysis at the temperature near that of human body were studied. β-acryloxypropionic acid-styrene copolymer was used as drug carrier and it reacted with the isoniazidum drug through ma-cromolecular reaction. The IR analysis of products demonstrated that the conversion of car-oxylic group could reach 61%. The results of neutral or acidic hydrolysis of P(St-co-APA) attaching isoniazidum showed that the hydrolysis of the macromolecular-drug could be con-trolled due to the particular structure of acryloxypropionic acid unit.

关键词

丙烯酸β-羧乙酯大分子酰胺（异烟肼）中性-酸性水解释放

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