Ming-zhi Wang, Jian-zhong Du. Progress in Syntheses and Applications of Polypeptides and Polypeptide-based Copolymers by NCA Polymerization[J]. Acta Polymerica Sinica, 2014,(9):1183-1194.
Ming-zhi Wang, Jian-zhong Du. Progress in Syntheses and Applications of Polypeptides and Polypeptide-based Copolymers by NCA Polymerization[J]. Acta Polymerica Sinica, 2014,(9):1183-1194. DOI: 10.11777/j.issn1000-3304.2014.14125.
Polypeptides and their hybrid copolymers have aroused much attention in biomedical fields due to their excellent biocompatibility and biodegradability.N-Carboxyanhydrides (NCA) can be polymerized into polypeptides and their hybrid copolymers via ring-opening polymerization with high efficiency and high yield.Also
polymers synthesized by this method have controlled chain length and molecular weight distribution.In this review
we have summarized the mechanism of NCA ring-opening polymerization
the methods for synthesizing NCA monomers
syntheses of polypeptides and polypeptide-based copolymers
and their applications in hydrogel
membranes
adhesives
antimicrobial vesicles and self-assembly
etc.We also highlight the solution behaviors of polypeptide-based copolymers which can form many functional nanostructures such as antibacterial polymer vesicles for anticancer drug delivery.Finally
we put forward the perspective on the research of polypeptide and polypeptide hybrids.