A novel biodegradable PLGA/TiO2 organic-inorganic hybrid nano-material was prepared by the reaction between activated carboxyl-terminated PLGA

which was synthesized by PLGA and succinic anhydride with TEA as catalyzer

and amino-terminated TiO2 nano-particles which were modified by amino propyltriethoxysilane (KH550).The structure and morphology of the materials were characterized by Fourier transform infrared spectroscopy (FTIR)

1H nuclear magnetic resonance (1H-NMR)

thermogravimetic analysis (TGA)

environmental scanning electron microscopy (ESEM) and transmission electron microscopy (TEM) methods.The results showed that the PLGA was grafted successfully on the surface of nano scale TiO2 particles with 14% average grafting; PLGA/TiO2 hybrid nano-material dispersed uniformly in BSA aqueous solution without obvious aggregation and showed a better adsorptivity (81.3%) to model drug BSA as compared with that(43.3%) of pure TiO2 nanoparticles.Different kinds of the nanopaticles containing proteins BSA (TiO2-BSA and PLGA/TiO2-BSA) were loaded into polymer microspheres with PLGA as carrier by the solid-in-oil-in-water emulsion method.The drug loading content

entrapment efficiency and drug release in vitro of different drug containing microspheres were tested.The results indicated that the microspheres of PTB/P showed smooth morphologies

high entrapment efficiency 96% and drug loading content 14.6% and decreased burst effect of drug

compared with TB/P microspheres.