Selenium (Se)

known as an essential trace elements

is closely related to human health and diseases.This essential trace element exists in at least 25 selenoproteins in the form of selenocysteine residue

which performs a variety of biological functions.Among these selenoproteins

glutathione peroxidase (GPx) is a well-known antioxidase

since it catalyzes the reduction of harmful peroxide by glutathione and protects cells against oxidative damage.Herein

some strategies and methods are presented to construct GPx mimics based on protein scaffolds.Through these studies

we expect to gain better understanding of the biological properties of selenoprotein

and even develop more effective approaches to create new selenoprotein mimics.