Polymer beads containing β-cycledextrin(β-CD) were prepared by inverse emulsion polymerization

and then

the polymer beads with thermo- and pH sensitivities were synthesized by atom transfer radical polymerization (ATRP) using N

N-dimethylaminoethyl methacrylate (DMAEMA) as a functional monomer and anterior chloroacetylated β-CD as the initiator．Chain structure and their compositions for polymers grafting with poly(N

N-dimethylaminoethyl methacrylate)(PDMAEMA) were characterized using infrared spectroscopy

element analysis

DSC and TGA The thermo- and pH sensitivities for polymers containing β-eyclodextrin and PDMAEMA were inspected directly with a polarizing microscope equipping with a hot stage Finally

the controHed drug release behaviors of these polymersweYe studied using anti-cancer drugs

genistein (GNT) and chlorambucil (CLB) as model compounds Results show that the release efficiency for drugs depends on the pH value which can act as an“on-off”switch during the test It was indicated that a controlled drug delivery system could be established according to these experimental data．