Alginate microspheres were formed by coagulation of sedium alginate in CaCl2 solutions

followed by lyophilization which could create the porous structure．Bovine serum albumin (BSA) was incorporated into the nficmspheres by mixing BSA with sodium alginate prior to coagulation．The release behavior of BSA from the Ca-alginate microspheres was studied．Fuaher．the alginate microspheres loaded with BSA were embedded in PLGA films by mixing the alginme miemspheres with PLGA solutions in order to study the sustained release of BSA from the PLGA film

which is widdy used as cell scaffold materials in tissue engineering．The mlease behavior of BSA from the PLGA film embedded alginate mlcrospheres indicated potential application for keeping the bioaetivity of the growth factor．