LU Lingbin, LIU Suqin, HUANG Kelong, XIAO Xuxian. STUDY ON DEGRADABILITY OF MICROSPHERES MADE OF CARBON DIOXIDE/PROPYLENE OXIDE/γ-BUTYROLACTONE COPOLYMER[J]. Acta Polymerica Sinica, 2005,(4):621-624.
LU Lingbin, LIU Suqin, HUANG Kelong, XIAO Xuxian. STUDY ON DEGRADABILITY OF MICROSPHERES MADE OF CARBON DIOXIDE/PROPYLENE OXIDE/γ-BUTYROLACTONE COPOLYMER[J]. Acta Polymerica Sinica, 2005,(4):621-624.DOI:
Some methods have been developed to use CO2 as the raw material to produce degradable polymeric materials.The terpolymer of carbonate(PPGC) synthesized with the terpulymerization of CO2
pmpylene oxide and γ-butyrolaetone(GBL).GBL offered an ester structural unit making the eopolymer easier to hydrolyze.Hence
PPCG should be of good degradability.In order to study its degradability
the polymer PPCG was used as materials for drag loading.The drug-loaded mierospheres were obtained by the W/O/W type emulsions method.The mierespheres were spherical in shape with smooth surfaces and good dispersion.The drug loading and encapsulation efficiency were 36.7% and 78.6%。respectively.The degradative behave was studied by SEM
XRD arid dmg release carves in different degradation medium were obtained.It was found that these microspheres could be degraded at faster speed in the basic media
while could not be degraded in the acidic media.The higher pH value of the medium was