A new method

in which the polymerization of the shell component accompanies the self-assembly of macromolecules

was proposed to prepare core-shell nanospheres.Based on this in situ polymerization method

thermo-sensitive core-shell nanospheres with poly(ε-caprolactone) (PCL) core and poly(N-isopropylacrylamide) (PNIPAM) shell were prepared from monomer NIPAM and crosslinker methylene bisacrylamide (MBA).The influences of the total amount of monomer and crosslinker

the target crosslinking degree of PNIPAM shell

the initial concentration of PCL in DMF and the content of initiator AIBN on the yield of PNIPAM shell

the size

the thermo-sensitive behavior and the morphology of PCL/PNIPAM core-shell nanospheres were studied in details.The results show that during the preparation of PCL/PNIPAM core-shell nanospheres

the polymerization on the surface of PCL nanoparticles competes with that in the water.Increasing the amount of initiator AIBN properly is favorable to the preparation of PCL/PNIPAM core-shell nanospheres with controlled core/shell weight ratio.In addition

the relatively higher reactivity of cross-linker MBA compared with NIPAM leads to the formation of unevenly crosslinked PNIPAM shells.