Electrospinning has been recognized as an efficient method for fabricating continuous nanofibers for

e．g．

biomedical applications．With a modified CO-axial electrospinning technique

a pencil-like

core-shell composite nanofiber can be obtained．In this paper

two pure drugs

resveratrol and gentamycin sulfate

were encapsulated respectively into the cores of biodegradable polycaprolactone(PCL)uhrafine fibers with a diameter down to hundreds of nanometers．The fabrication process of these nanofibers and their micro-structural characteristics were investigated．Such composite nanofibers can be useful in controlled drug release and in the development of new medical devices as absorbable sutures inside human body or wound dressing materials．