A tree—type full substituted phenylalanine—poly(lysine)dendrimer(Phe—PL dendrimer) aws synthesized.Poly(lysine)dendrimer(generation 3)(PL dendfimer G3)was prepared using N
N'-di(fluorenylmethoxy—carbonyloxy)-L-Lysine as both the branching agent and the dendritic branch by solid phase peptide couphng method on 1% cross—linked polystyrene bead functionalized with Fmoc-glycine.Then Phenylalanine was bound to PL dendfimer G3 to form full substituted Phe—PL dendrimer.The product was characterized with MALDI—TOF MS and NMR.The results of MS demonstrated that they both Fmoc—PL and Phe—PL dendrimers G3 have exclusive molecular weights.indicating that they could be developed as a potential ideal nonviral vector.